Transient activation of Ras-dependent signalling at the early stages of Herbimycin A induced erythroid differentiation of human K562 cells

To study the dynamics of Ras-dependent signalling in the course of Herbimycin A induced erythroid differentiation of human erythroleukemia K562 cells. p21Ras functional activity was analyzed by direct measurement of GTP/GDP ratio in anti-p21Ras immunoprecipitates of K562 cells previously incubated w...

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Veröffentlicht in:	Experimental oncology 2005-03, Vol.27 (1), p.31-37
Hauptverfasser:	Drobot, Lyudmyla, Husak, Zvenyslava, Ilnytska, Olga, Igumentseva, Natalia, Oleksyn, Halyna, Kusen', Stepan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - drug effects Adaptor Proteins, Signal Transducing - metabolism Benzoquinones Blotting, Western Cell Differentiation - drug effects Cell Line, Tumor Electrophoretic Mobility Shift Assay Enzyme Inhibitors - pharmacology Erythroid Cells - cytology Erythroid Cells - drug effects Glutathione Transferase - drug effects Glutathione Transferase - metabolism GRB2 Adaptor Protein Guanosine Diphosphate - metabolism Guanosine Triphosphate - metabolism Humans Lactams, Macrocyclic Phosphorylation - drug effects Proto-Oncogene Proteins p21(ras) - drug effects Proto-Oncogene Proteins p21(ras) - metabolism Quinones - pharmacology Rifabutin - analogs & derivatives Signal Transduction - drug effects Signal Transduction - physiology Tyrosine - drug effects Tyrosine - metabolism
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