Prognostic Value of Tumor-Infiltrating Dendritic Cells in Colorectal Cancer: Role of Maturation Status and Intratumoral Localization
The clinical significance of tumor-infiltrating dendritic cells has been reported in a variety of human solid tumors as shown by the correlations found between the presence of tumor-infiltrating dendritic cells and clinical prognosis. In this study, we evaluated whether there is an association betwe...
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| Veröffentlicht in: | Clinical cancer research 2005-04, Vol.11 (7), p.2576-2582 |
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| creator | SANDEL, Maro H DADABAYEV, Alisher R VAN DE VELDE, Cornelis J. H KUPPEN, Peter J. K MENON, Anand G MORREAU, Hans MELIEF, Cornelis J. M OFFRINGA, Rienk VAN DER BURG, Sjoerd H JANSSEN-VAN RHIJN, Connie M ENSINK, N. Geeske TOLLENAAR, Rob A. E. M |
| description | The clinical significance of tumor-infiltrating dendritic cells has been reported in a variety of human solid tumors as shown
by the correlations found between the presence of tumor-infiltrating dendritic cells and clinical prognosis. In this study,
we evaluated whether there is an association between the presence and maturation status of tumor-infiltrating dendritic cells,
T lymphocytes, and clinical course in 104 primary tumor samples of patients with colorectal cancer. Dendritic cells were identified
with four different markers (S-100, HLA class II, CD208, and CD1a) in double immunohistochemistry, with laminin as second
marker to support the exact localization. Tumor-infiltrating dendritic cells showed a distinct infiltration pattern based
on their maturation status. CD1a-positive dendritic cells resided in the advancing tumor margins in relatively high numbers,
whereas mature CD208-positive dendritic cells were sparsely present in the tumor epithelium but mainly distributed in the
tumor stroma and advancing tumor margin. Furthermore, high infiltration of CD1a-positive dendritic cells in the tumor epithelium
was significantly correlated to the infiltration of CD4 lymphocytes ( P = 0.006). Patients with relatively high numbers of mature CD208-positive infiltrating dendritic cells in the tumor epithelium
had a shorter overall survival ( P = 0.004). In addition, patients with relatively high numbers of CD1a-positive dendritic cells in the advancing margin of
the tumor had a shorter disease-free survival ( P = 0.03). We found that tumor-infiltrating dendritic cells had preferential infiltration sites within a tumor, affected local
tumor cell-immune cell interactions, and correlated to the clinical prognosis of colorectal cancer patients. |
| doi_str_mv | 10.1158/1078-0432.CCR-04-1448 |
| format | Article |
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by the correlations found between the presence of tumor-infiltrating dendritic cells and clinical prognosis. In this study,
we evaluated whether there is an association between the presence and maturation status of tumor-infiltrating dendritic cells,
T lymphocytes, and clinical course in 104 primary tumor samples of patients with colorectal cancer. Dendritic cells were identified
with four different markers (S-100, HLA class II, CD208, and CD1a) in double immunohistochemistry, with laminin as second
marker to support the exact localization. Tumor-infiltrating dendritic cells showed a distinct infiltration pattern based
on their maturation status. CD1a-positive dendritic cells resided in the advancing tumor margins in relatively high numbers,
whereas mature CD208-positive dendritic cells were sparsely present in the tumor epithelium but mainly distributed in the
tumor stroma and advancing tumor margin. Furthermore, high infiltration of CD1a-positive dendritic cells in the tumor epithelium
was significantly correlated to the infiltration of CD4 lymphocytes ( P = 0.006). Patients with relatively high numbers of mature CD208-positive infiltrating dendritic cells in the tumor epithelium
had a shorter overall survival ( P = 0.004). In addition, patients with relatively high numbers of CD1a-positive dendritic cells in the advancing margin of
the tumor had a shorter disease-free survival ( P = 0.03). We found that tumor-infiltrating dendritic cells had preferential infiltration sites within a tumor, affected local
tumor cell-immune cell interactions, and correlated to the clinical prognosis of colorectal cancer patients.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>DOI: 10.1158/1078-0432.CCR-04-1448</identifier><identifier>PMID: 15814636</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>adenocarcinoma ; Adolescent ; Adult ; Antigen-presenting cells ; Antigens, CD - analysis ; Antigens, CD1 - analysis ; Antineoplastic agents ; Biological and medical sciences ; CD1a ; CD208 ; Child ; Child, Preschool ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - pathology ; Dendritic Cells - chemistry ; Dendritic Cells - pathology ; Epithelium - chemistry ; Epithelium - pathology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Histocompatibility Antigens Class II - analysis ; HLA Antigens - analysis ; Humans ; Immunohistochemistry ; Infant ; Infant, Newborn ; Lysosomal Membrane Proteins ; Male ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Pharmacology. Drug treatments ; Prognosis ; S100 Proteins - analysis ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Survival Analysis ; tumor-infiltrating leukocytes ; Tumors</subject><ispartof>Clinical cancer research, 2005-04, Vol.11 (7), p.2576-2582</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-dadcb0f7ea4702be36821abd5464213f6914884c7423979e8007599e0113e8a53</citedby><cites>FETCH-LOGICAL-c514t-dadcb0f7ea4702be36821abd5464213f6914884c7423979e8007599e0113e8a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16679546$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15814636$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SANDEL, Maro H</creatorcontrib><creatorcontrib>DADABAYEV, Alisher R</creatorcontrib><creatorcontrib>VAN DE VELDE, Cornelis J. H</creatorcontrib><creatorcontrib>KUPPEN, Peter J. K</creatorcontrib><creatorcontrib>MENON, Anand G</creatorcontrib><creatorcontrib>MORREAU, Hans</creatorcontrib><creatorcontrib>MELIEF, Cornelis J. M</creatorcontrib><creatorcontrib>OFFRINGA, Rienk</creatorcontrib><creatorcontrib>VAN DER BURG, Sjoerd H</creatorcontrib><creatorcontrib>JANSSEN-VAN RHIJN, Connie M</creatorcontrib><creatorcontrib>ENSINK, N. Geeske</creatorcontrib><creatorcontrib>TOLLENAAR, Rob A. E. M</creatorcontrib><title>Prognostic Value of Tumor-Infiltrating Dendritic Cells in Colorectal Cancer: Role of Maturation Status and Intratumoral Localization</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>The clinical significance of tumor-infiltrating dendritic cells has been reported in a variety of human solid tumors as shown
by the correlations found between the presence of tumor-infiltrating dendritic cells and clinical prognosis. In this study,
we evaluated whether there is an association between the presence and maturation status of tumor-infiltrating dendritic cells,
T lymphocytes, and clinical course in 104 primary tumor samples of patients with colorectal cancer. Dendritic cells were identified
with four different markers (S-100, HLA class II, CD208, and CD1a) in double immunohistochemistry, with laminin as second
marker to support the exact localization. Tumor-infiltrating dendritic cells showed a distinct infiltration pattern based
on their maturation status. CD1a-positive dendritic cells resided in the advancing tumor margins in relatively high numbers,
whereas mature CD208-positive dendritic cells were sparsely present in the tumor epithelium but mainly distributed in the
tumor stroma and advancing tumor margin. Furthermore, high infiltration of CD1a-positive dendritic cells in the tumor epithelium
was significantly correlated to the infiltration of CD4 lymphocytes ( P = 0.006). Patients with relatively high numbers of mature CD208-positive infiltrating dendritic cells in the tumor epithelium
had a shorter overall survival ( P = 0.004). In addition, patients with relatively high numbers of CD1a-positive dendritic cells in the advancing margin of
the tumor had a shorter disease-free survival ( P = 0.03). We found that tumor-infiltrating dendritic cells had preferential infiltration sites within a tumor, affected local
tumor cell-immune cell interactions, and correlated to the clinical prognosis of colorectal cancer patients.</description><subject>adenocarcinoma</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Antigen-presenting cells</subject><subject>Antigens, CD - analysis</subject><subject>Antigens, CD1 - analysis</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>CD1a</subject><subject>CD208</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Dendritic Cells - chemistry</subject><subject>Dendritic Cells - pathology</subject><subject>Epithelium - chemistry</subject><subject>Epithelium - pathology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Histocompatibility Antigens Class II - analysis</subject><subject>HLA Antigens - analysis</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Lysosomal Membrane Proteins</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Pharmacology. Drug treatments</subject><subject>Prognosis</subject><subject>S100 Proteins - analysis</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Survival Analysis</subject><subject>tumor-infiltrating leukocytes</subject><subject>Tumors</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuPFCEUhYnROOPoT9Cw0bipkTeUO1O-OmmjGUe3hKaobgwNM1AVo2t_uNDdZpauOIvvnMu9B4CnGF1izNUrjKTqEKPkchiuqugwY-oeOMecy44Swe9X_Y85A49K-YEQZhixh-CsBmAmqDgHf77ktI2pzN7C7yYsDqYJXi_7lLtVnHyYs5l93MK3Lo7ZN2pwIRToIxxSSNnZ2QQ4mGhdfg2vUjgEfDLz0owpwq9z1QWaOMJVbGktu1rWyZrgfx-gx-DBZEJxT07vBfj2_t318LFbf_6wGt6sO8sxm7vRjHaDJukMk4hsHBWKYLMZOROMYDqJHjOlmJWM0F72TiEked87hDF1ynB6AV4cc29yul1cmfXeF1v3MdGlpWghJUZIoP-CuJdEEtUS-RG0OZWS3aRvst-b_EtjpFtPunWgWwe69lSFbj1V37PTgGWzd-Od61RMBZ6fAFPqoaZcL-zLHSeE7OvelXt55HZ-u_vps9P20EV2xZlsd_UTWmrCpaB_Aas5qgg</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>SANDEL, Maro H</creator><creator>DADABAYEV, Alisher R</creator><creator>VAN DE VELDE, Cornelis J. H</creator><creator>KUPPEN, Peter J. K</creator><creator>MENON, Anand G</creator><creator>MORREAU, Hans</creator><creator>MELIEF, Cornelis J. M</creator><creator>OFFRINGA, Rienk</creator><creator>VAN DER BURG, Sjoerd H</creator><creator>JANSSEN-VAN RHIJN, Connie M</creator><creator>ENSINK, N. Geeske</creator><creator>TOLLENAAR, Rob A. E. M</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20050401</creationdate><title>Prognostic Value of Tumor-Infiltrating Dendritic Cells in Colorectal Cancer: Role of Maturation Status and Intratumoral Localization</title><author>SANDEL, Maro H ; DADABAYEV, Alisher R ; VAN DE VELDE, Cornelis J. H ; KUPPEN, Peter J. K ; MENON, Anand G ; MORREAU, Hans ; MELIEF, Cornelis J. M ; OFFRINGA, Rienk ; VAN DER BURG, Sjoerd H ; JANSSEN-VAN RHIJN, Connie M ; ENSINK, N. Geeske ; TOLLENAAR, Rob A. E. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-dadcb0f7ea4702be36821abd5464213f6914884c7423979e8007599e0113e8a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>adenocarcinoma</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Antigen-presenting cells</topic><topic>Antigens, CD - analysis</topic><topic>Antigens, CD1 - analysis</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>CD1a</topic><topic>CD208</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Dendritic Cells - chemistry</topic><topic>Dendritic Cells - pathology</topic><topic>Epithelium - chemistry</topic><topic>Epithelium - pathology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Histocompatibility Antigens Class II - analysis</topic><topic>HLA Antigens - analysis</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Lysosomal Membrane Proteins</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Pharmacology. Drug treatments</topic><topic>Prognosis</topic><topic>S100 Proteins - analysis</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Survival Analysis</topic><topic>tumor-infiltrating leukocytes</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SANDEL, Maro H</creatorcontrib><creatorcontrib>DADABAYEV, Alisher R</creatorcontrib><creatorcontrib>VAN DE VELDE, Cornelis J. H</creatorcontrib><creatorcontrib>KUPPEN, Peter J. 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M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SANDEL, Maro H</au><au>DADABAYEV, Alisher R</au><au>VAN DE VELDE, Cornelis J. H</au><au>KUPPEN, Peter J. K</au><au>MENON, Anand G</au><au>MORREAU, Hans</au><au>MELIEF, Cornelis J. M</au><au>OFFRINGA, Rienk</au><au>VAN DER BURG, Sjoerd H</au><au>JANSSEN-VAN RHIJN, Connie M</au><au>ENSINK, N. Geeske</au><au>TOLLENAAR, Rob A. E. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Value of Tumor-Infiltrating Dendritic Cells in Colorectal Cancer: Role of Maturation Status and Intratumoral Localization</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>11</volume><issue>7</issue><spage>2576</spage><epage>2582</epage><pages>2576-2582</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>The clinical significance of tumor-infiltrating dendritic cells has been reported in a variety of human solid tumors as shown
by the correlations found between the presence of tumor-infiltrating dendritic cells and clinical prognosis. In this study,
we evaluated whether there is an association between the presence and maturation status of tumor-infiltrating dendritic cells,
T lymphocytes, and clinical course in 104 primary tumor samples of patients with colorectal cancer. Dendritic cells were identified
with four different markers (S-100, HLA class II, CD208, and CD1a) in double immunohistochemistry, with laminin as second
marker to support the exact localization. Tumor-infiltrating dendritic cells showed a distinct infiltration pattern based
on their maturation status. CD1a-positive dendritic cells resided in the advancing tumor margins in relatively high numbers,
whereas mature CD208-positive dendritic cells were sparsely present in the tumor epithelium but mainly distributed in the
tumor stroma and advancing tumor margin. Furthermore, high infiltration of CD1a-positive dendritic cells in the tumor epithelium
was significantly correlated to the infiltration of CD4 lymphocytes ( P = 0.006). Patients with relatively high numbers of mature CD208-positive infiltrating dendritic cells in the tumor epithelium
had a shorter overall survival ( P = 0.004). In addition, patients with relatively high numbers of CD1a-positive dendritic cells in the advancing margin of
the tumor had a shorter disease-free survival ( P = 0.03). We found that tumor-infiltrating dendritic cells had preferential infiltration sites within a tumor, affected local
tumor cell-immune cell interactions, and correlated to the clinical prognosis of colorectal cancer patients.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>15814636</pmid><doi>10.1158/1078-0432.CCR-04-1448</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical cancer research, 2005-04, Vol.11 (7), p.2576-2582 |
| issn | 1078-0432 1557-3265 |
| language | eng |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | adenocarcinoma Adolescent Adult Antigen-presenting cells Antigens, CD - analysis Antigens, CD1 - analysis Antineoplastic agents Biological and medical sciences CD1a CD208 Child Child, Preschool Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Dendritic Cells - chemistry Dendritic Cells - pathology Epithelium - chemistry Epithelium - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Histocompatibility Antigens Class II - analysis HLA Antigens - analysis Humans Immunohistochemistry Infant Infant, Newborn Lysosomal Membrane Proteins Male Medical sciences Middle Aged Neoplasm Staging Pharmacology. Drug treatments Prognosis S100 Proteins - analysis Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Analysis tumor-infiltrating leukocytes Tumors |
| title | Prognostic Value of Tumor-Infiltrating Dendritic Cells in Colorectal Cancer: Role of Maturation Status and Intratumoral Localization |
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