Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion

A retrospective review of patients who underwent an anterior cervical fusion using recombinant human bone morphogenetic protein (rhBMP)-2 with an absorbable collagen sponge (INFUSE; Medtronic Sofamor Danek, Minneapolis, MN). To ascertain the complication rate after the use of high-dose INFUSE in ant...

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Veröffentlicht in:	Spine (Philadelphia, Pa. 1976) Pa. 1976), 2006-03, Vol.31 (5), p.542-547
Hauptverfasser:	SHIELDS, Lisa B. E, RAQUE, George H, GLASSMAN, Steven D, CAMPBELL, Mitchell, VITAZ, Todd, HARPRING, John, SHIELDS, Christopher B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins - adverse effects Bone Substitutes Cerebrospinal fluid. Meninges. Spinal cord Cervical Vertebrae - surgery Diskectomy Female Hormones. Endocrine system Humans Internal Fixators Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Orthopedic surgery Osseointegration - drug effects Pharmacology. Drug treatments Postoperative Complications - etiology Recombinant Proteins - adverse effects Retrospective Studies Spinal Fusion - adverse effects Spinal Fusion - instrumentation Spinal Fusion - methods Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgical Sponges Transforming Growth Factor beta - adverse effects
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