Health, Neurologic, and Cognitive Status of HIV-Infected, Long-Surviving, and Antiretroviral-Naive Ugandan Children
The purpose of this study was to assess the health status and school-age neurodevelopmental progress of antiretroviral treatment (ARVT)-naive, HIV-infected Ugandan children who had been followed as part of cohorts of children born to HIV-infected and -noninfected mothers between 1989 and 1993. Twent...
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Veröffentlicht in: | Pediatrics (Evanston) 2006-03, Vol.117 (3), p.729-740 |
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description | The purpose of this study was to assess the health status and school-age neurodevelopmental progress of antiretroviral treatment (ARVT)-naive, HIV-infected Ugandan children who had been followed as part of cohorts of children born to HIV-infected and -noninfected mothers between 1989 and 1993.
Twenty-eight children, aged 6 to 12 years, vertically infected with HIV-1 and never treated with ARVT were evaluated in terms of health status, neurologic, and psychometric testing. A randomly selected group of 42 seroreverters and 37 HIV-1 negative children who were age- and gender-matched and who had been followed in the same cohorts were evaluated also. The families studied were homogenous in their socioeconomic status. None of the mothers or children had received ARVT or been exposed to illicit drugs.
The HIV-infected children showed significantly more evidence of acute malnutrition. They also had more illness, especially parotitis, otitis media, upper respiratory infections, and lymphadenopathy. However, they did not differ significantly in neurologic and cognitive assessments when compared with age- and gender-matched seroreverter and HIV-negative children. They were in the normal range with respect to neurologic and psychometric development measures.
These children seem to represent a significant subgroup of HIV-infected child survivors for whom the progress of the disease is less aggressive throughout early life. Given the fact that many infants, especially in developing countries, continue to be born without the benefit of perinatal ARVT, there will likely continue to be many older HIV-infected children in the same situation as those described in this follow-up study. They will not have been recognized as being HIV-infected. It is important that such children be identified and offered access to ARVT and other appropriate support services. |
doi_str_mv | 10.1542/peds.2004-2699 |
format | Article |
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Twenty-eight children, aged 6 to 12 years, vertically infected with HIV-1 and never treated with ARVT were evaluated in terms of health status, neurologic, and psychometric testing. A randomly selected group of 42 seroreverters and 37 HIV-1 negative children who were age- and gender-matched and who had been followed in the same cohorts were evaluated also. The families studied were homogenous in their socioeconomic status. None of the mothers or children had received ARVT or been exposed to illicit drugs.
The HIV-infected children showed significantly more evidence of acute malnutrition. They also had more illness, especially parotitis, otitis media, upper respiratory infections, and lymphadenopathy. However, they did not differ significantly in neurologic and cognitive assessments when compared with age- and gender-matched seroreverter and HIV-negative children. They were in the normal range with respect to neurologic and psychometric development measures.
These children seem to represent a significant subgroup of HIV-infected child survivors for whom the progress of the disease is less aggressive throughout early life. Given the fact that many infants, especially in developing countries, continue to be born without the benefit of perinatal ARVT, there will likely continue to be many older HIV-infected children in the same situation as those described in this follow-up study. They will not have been recognized as being HIV-infected. It is important that such children be identified and offered access to ARVT and other appropriate support services.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2004-2699</identifier><identifier>PMID: 16510653</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>Elk Grove Village, IL: Am Acad Pediatrics</publisher><subject>Acquired immune deficiency syndrome ; AIDS ; Anti-Retroviral Agents - therapeutic use ; Biological and medical sciences ; Child ; Child Development ; Children & youth ; Cognition ; Cognition & reasoning ; Cohort Studies ; Developmental Disabilities - etiology ; Female ; Follow-Up Studies ; General aspects ; Health aspects ; Health Status ; HIV infection in children ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV Infections - psychology ; HIV-1 ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infants ; Infectious diseases ; Intelligence ; Male ; Medical sciences ; Motor ability ; Nervous System Diseases - complications ; Neurologic Examination ; Neuropsychology ; Pediatric HIV infections ; Pediatrics ; Psychological aspects ; Psychomotor Performance ; Survivors ; Uganda ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>Pediatrics (Evanston), 2006-03, Vol.117 (3), p.729-740</ispartof><rights>2006 INIST-CNRS</rights><rights>COPYRIGHT 2006 American Academy of Pediatrics</rights><rights>Copyright American Academy of Pediatrics Mar 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c569t-33618fff40a9fc7ac805343950dc9fe9ea23b43a54a1df1bcb1cdfcd2ca2d6fe3</citedby><cites>FETCH-LOGICAL-c569t-33618fff40a9fc7ac805343950dc9fe9ea23b43a54a1df1bcb1cdfcd2ca2d6fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17592369$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16510653$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bagenda, Danstan</creatorcontrib><creatorcontrib>Nassali, Annette</creatorcontrib><creatorcontrib>Kalyesubula, Israel</creatorcontrib><creatorcontrib>Sherman, Becky</creatorcontrib><creatorcontrib>Drotar, Dennis</creatorcontrib><creatorcontrib>Boivin, Michael J</creatorcontrib><creatorcontrib>Olness, Karen</creatorcontrib><title>Health, Neurologic, and Cognitive Status of HIV-Infected, Long-Surviving, and Antiretroviral-Naive Ugandan Children</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>The purpose of this study was to assess the health status and school-age neurodevelopmental progress of antiretroviral treatment (ARVT)-naive, HIV-infected Ugandan children who had been followed as part of cohorts of children born to HIV-infected and -noninfected mothers between 1989 and 1993.
Twenty-eight children, aged 6 to 12 years, vertically infected with HIV-1 and never treated with ARVT were evaluated in terms of health status, neurologic, and psychometric testing. A randomly selected group of 42 seroreverters and 37 HIV-1 negative children who were age- and gender-matched and who had been followed in the same cohorts were evaluated also. The families studied were homogenous in their socioeconomic status. None of the mothers or children had received ARVT or been exposed to illicit drugs.
The HIV-infected children showed significantly more evidence of acute malnutrition. They also had more illness, especially parotitis, otitis media, upper respiratory infections, and lymphadenopathy. However, they did not differ significantly in neurologic and cognitive assessments when compared with age- and gender-matched seroreverter and HIV-negative children. They were in the normal range with respect to neurologic and psychometric development measures.
These children seem to represent a significant subgroup of HIV-infected child survivors for whom the progress of the disease is less aggressive throughout early life. Given the fact that many infants, especially in developing countries, continue to be born without the benefit of perinatal ARVT, there will likely continue to be many older HIV-infected children in the same situation as those described in this follow-up study. They will not have been recognized as being HIV-infected. It is important that such children be identified and offered access to ARVT and other appropriate support services.</description><subject>Acquired immune deficiency syndrome</subject><subject>AIDS</subject><subject>Anti-Retroviral Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child Development</subject><subject>Children & youth</subject><subject>Cognition</subject><subject>Cognition & reasoning</subject><subject>Cohort Studies</subject><subject>Developmental Disabilities - etiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Health aspects</subject><subject>Health Status</subject><subject>HIV infection in children</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - psychology</subject><subject>HIV-1</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infants</subject><subject>Infectious diseases</subject><subject>Intelligence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Motor ability</subject><subject>Nervous System Diseases - complications</subject><subject>Neurologic Examination</subject><subject>Neuropsychology</subject><subject>Pediatric HIV infections</subject><subject>Pediatrics</subject><subject>Psychological aspects</subject><subject>Psychomotor Performance</subject><subject>Survivors</subject><subject>Uganda</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt2LEzEUxQdR3Lr66qMMgoLQqfmYzEweS9Ftoew-rOtrSDM30yzTpCaZqv-9GVqoKwXJQ8LN79yTXE6WvcVohllJPu-hDTOCUFmQivNn2QQj3hQlqdnzbIIQxUWJELvKXoXwiBLGavIyu8IVw6hidJKFJcg-bqf5LQze9a4zappL2-YL11kTzQHy-yjjEHKn8-Xqe7GyGlSEdpqvne2K-8EfzMHY7qia22g8RO8Oxsu-uJVjg4cuXUmbL7ambz3Y19kLLfsAb077dfbw9cu3xbJY392sFvN1oVjFY0FphRutdYkk16qWqkGMlpQz1CqugYMkdFNSyUqJW403aoNVq1VLlCRtpYFeZx-Pfffe_RggRLEzQUHfSwtuCKKqa9TwpvwviDlPtjVK4Pt_wEc3eJs-IQhpSkwq1CSoOEKd7EEYq130UnVgIY3EWdAmlee4pBVhSZL42QU-rRZ2Rl0UfHoiSEyEX7GTQwiiuVk_ZYtLrHJ9Dx2INO_F3cXHKO9C8KDF3pud9L8FRmJMnBgTJ8bEiTFxSfDuNJJhs4P2jJ8iloAPJ0AGJXvtpVUmnLmacUIrfnbemm77M6VodDIyeqPCX0eMa0FFTTj9A9Jw7KI</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>Bagenda, Danstan</creator><creator>Nassali, Annette</creator><creator>Kalyesubula, Israel</creator><creator>Sherman, Becky</creator><creator>Drotar, Dennis</creator><creator>Boivin, Michael J</creator><creator>Olness, Karen</creator><general>Am Acad Pediatrics</general><general>American Academy of Pediatrics</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20060301</creationdate><title>Health, Neurologic, and Cognitive Status of HIV-Infected, Long-Surviving, and Antiretroviral-Naive Ugandan Children</title><author>Bagenda, Danstan ; Nassali, Annette ; Kalyesubula, Israel ; Sherman, Becky ; Drotar, Dennis ; Boivin, Michael J ; Olness, Karen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c569t-33618fff40a9fc7ac805343950dc9fe9ea23b43a54a1df1bcb1cdfcd2ca2d6fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>AIDS</topic><topic>Anti-Retroviral Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child Development</topic><topic>Children & youth</topic><topic>Cognition</topic><topic>Cognition & reasoning</topic><topic>Cohort Studies</topic><topic>Developmental Disabilities - etiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Health aspects</topic><topic>Health Status</topic><topic>HIV infection in children</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - psychology</topic><topic>HIV-1</topic><topic>Human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infants</topic><topic>Infectious diseases</topic><topic>Intelligence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Motor ability</topic><topic>Nervous System Diseases - complications</topic><topic>Neurologic Examination</topic><topic>Neuropsychology</topic><topic>Pediatric HIV infections</topic><topic>Pediatrics</topic><topic>Psychological aspects</topic><topic>Psychomotor Performance</topic><topic>Survivors</topic><topic>Uganda</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bagenda, Danstan</creatorcontrib><creatorcontrib>Nassali, Annette</creatorcontrib><creatorcontrib>Kalyesubula, Israel</creatorcontrib><creatorcontrib>Sherman, Becky</creatorcontrib><creatorcontrib>Drotar, Dennis</creatorcontrib><creatorcontrib>Boivin, Michael J</creatorcontrib><creatorcontrib>Olness, Karen</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bagenda, Danstan</au><au>Nassali, Annette</au><au>Kalyesubula, Israel</au><au>Sherman, Becky</au><au>Drotar, Dennis</au><au>Boivin, Michael J</au><au>Olness, Karen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Health, Neurologic, and Cognitive Status of HIV-Infected, Long-Surviving, and Antiretroviral-Naive Ugandan Children</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>117</volume><issue>3</issue><spage>729</spage><epage>740</epage><pages>729-740</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>The purpose of this study was to assess the health status and school-age neurodevelopmental progress of antiretroviral treatment (ARVT)-naive, HIV-infected Ugandan children who had been followed as part of cohorts of children born to HIV-infected and -noninfected mothers between 1989 and 1993.
Twenty-eight children, aged 6 to 12 years, vertically infected with HIV-1 and never treated with ARVT were evaluated in terms of health status, neurologic, and psychometric testing. A randomly selected group of 42 seroreverters and 37 HIV-1 negative children who were age- and gender-matched and who had been followed in the same cohorts were evaluated also. The families studied were homogenous in their socioeconomic status. None of the mothers or children had received ARVT or been exposed to illicit drugs.
The HIV-infected children showed significantly more evidence of acute malnutrition. They also had more illness, especially parotitis, otitis media, upper respiratory infections, and lymphadenopathy. However, they did not differ significantly in neurologic and cognitive assessments when compared with age- and gender-matched seroreverter and HIV-negative children. They were in the normal range with respect to neurologic and psychometric development measures.
These children seem to represent a significant subgroup of HIV-infected child survivors for whom the progress of the disease is less aggressive throughout early life. Given the fact that many infants, especially in developing countries, continue to be born without the benefit of perinatal ARVT, there will likely continue to be many older HIV-infected children in the same situation as those described in this follow-up study. They will not have been recognized as being HIV-infected. It is important that such children be identified and offered access to ARVT and other appropriate support services.</abstract><cop>Elk Grove Village, IL</cop><pub>Am Acad Pediatrics</pub><pmid>16510653</pmid><doi>10.1542/peds.2004-2699</doi><tpages>12</tpages></addata></record> |
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subjects | Acquired immune deficiency syndrome AIDS Anti-Retroviral Agents - therapeutic use Biological and medical sciences Child Child Development Children & youth Cognition Cognition & reasoning Cohort Studies Developmental Disabilities - etiology Female Follow-Up Studies General aspects Health aspects Health Status HIV infection in children HIV Infections - complications HIV Infections - drug therapy HIV Infections - psychology HIV-1 Human immunodeficiency virus 1 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infants Infectious diseases Intelligence Male Medical sciences Motor ability Nervous System Diseases - complications Neurologic Examination Neuropsychology Pediatric HIV infections Pediatrics Psychological aspects Psychomotor Performance Survivors Uganda Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
title | Health, Neurologic, and Cognitive Status of HIV-Infected, Long-Surviving, and Antiretroviral-Naive Ugandan Children |
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