Nature of the Nucleosomal Barrier to RNA Polymerase II

In the cell, RNA polymerase II (pol II) efficiently transcribes DNA packaged into nucleosomes, but in vitro encounters with the nucleosomes induce catalytic inactivation (arrest) of the pol II core enzyme. To determine potential mechanisms making nucleosomes transparent to transcription in vivo, we...

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Veröffentlicht in:	Molecular cell 2005-04, Vol.18 (1), p.97-108
Hauptverfasser:	Kireeva, Maria L., Hancock, Brynne, Cremona, Gina H., Walter, Wendy, Studitsky, Vasily M., Kashlev, Mikhail
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence DNA - genetics Histones - metabolism Molecular Sequence Data Nucleosomes - genetics Nucleosomes - metabolism RNA Polymerase II - metabolism Transcription, Genetic Transcriptional Elongation Factors - metabolism
Online-Zugang:	Volltext
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