From genome to vaccines for leishmaniasis: Screening 100 novel vaccine candidates against murine Leishmania major infection

The genomic sequence of Leishmania major provides a rich source of vaccine candidates. One hundred randomly selected amastigote-expressed genes were screened as DNA vaccines, and efficacy determined following high-dose L. major footpad challenge in BALB/c mice. Fourteen protective novel vaccine cand...

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Veröffentlicht in:	Vaccine 2006-03, Vol.24 (14), p.2602-2616
Hauptverfasser:	Stober, Carmel B., Lange, Uta G., Roberts, Mark T.M., Gilmartin, Brian, Francis, Richard, Almeida, Renata, Peacock, Christopher S., McCann, Sharon, Blackwell, Jenefer M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Protozoan - administration & dosage Antigens, Protozoan - genetics Antigens, Protozoan - immunology Applied microbiology Biological and medical sciences Disease Models, Animal DNA, Protozoan - administration & dosage DNA, Protozoan - immunology Fundamental and applied biological sciences. Psychology Genome, Protozoan Human protozoal diseases Infectious diseases Leishmania genome Leishmania major Leishmania major - chemistry Leishmania major - genetics Leishmania major - immunology Leishmaniasis - prevention & control Leshmaniasis Medical sciences Mice Mice, Inbred BALB C Microbiology Parasitic diseases Parasitic–protozoan Protozoal diseases Protozoan Proteins - administration & dosage Protozoan Proteins - genetics Protozoan Vaccines - administration & dosage Protozoan Vaccines - genetics Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics
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