Requirement of the coiled-coil domain of PML-RARalpha oncoprotein for localization, sumoylation, and inhibition of monocyte differentiation

Homo-oligomerization via a coiled-coil (C-C) domain has been shown to be necessary for the promyelocytic leukemia (PML)-retinoic acid receptor-alpha (RARalpha) fusion protein to acquire oncogenic potential in acute promyelocytic leukemia. We show here that PML(DeltaC-C)-RARalpha, which contains a de...

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Veröffentlicht in:	Biochemical and biophysical research communications 2005-05, Vol.330 (3), p.746-754
Hauptverfasser:	Kim, Young-Eui, Kim, Dong-Yeon, Lee, Jang-Mi, Kim, Seong-Tae, Han, Tae-Hee, Ahn, Jin-Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Animals CCAAT-Enhancer-Binding Protein-beta - metabolism Cell Differentiation - drug effects Cell Line Cell Nucleus - drug effects Cell Nucleus - metabolism Gene Expression Regulation - drug effects Humans Monocytes - cytology Monocytes - drug effects Monocytes - metabolism Mutation - genetics Neoplasm Proteins - chemistry Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Oncogene Proteins, Fusion - chemistry Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Protein Binding Protein Structure, Quaternary Protein Structure, Tertiary SUMO-1 Protein - metabolism Tretinoin - pharmacology Ubiquitin-Conjugating Enzymes - metabolism
Online-Zugang:	Volltext
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