Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors

The synthesis and histone deacetylase (HDAC) inhibitory activity of mercaptoamides 2 and 3 is described. Inhibitors of histone deacetylases (HDAC) are emerging as a promising class of anti-cancer agents. A mercaptoamide functionality was designed as a bidentate zinc chelator and incorporated into th...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2005-04, Vol.15 (8), p.1969-1972
Hauptverfasser: Anandan, Sampath-Kumar, Ward, John S., Brokx, Richard D., Bray, Mark R., Patel, Dinesh V., Xiao, Xiao-Xi
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Sprache:eng
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