Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors
The synthesis and histone deacetylase (HDAC) inhibitory activity of mercaptoamides 2 and 3 is described. Inhibitors of histone deacetylases (HDAC) are emerging as a promising class of anti-cancer agents. A mercaptoamide functionality was designed as a bidentate zinc chelator and incorporated into th...
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Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2005-04, Vol.15 (8), p.1969-1972 |
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