Low titer maternal antibodies can both enhance and suppress B cell responses to a combined live attenuated human rotavirus and VLP-ISCOM vaccine

We investigated effects of low titer (Lo) circulating MatAb on protection and immunogenicity of attenuated (Att) human rotavirus (HRV) priming and 2/6-virus-like particle (VLP)-immunostimulating complex (ISCOM) boosting (AttHRV/VLP) or VLP-ISCOM alone vaccines. LoMatAb had both enhancing and suppres...

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Veröffentlicht in:	Vaccine 2006-03, Vol.24 (13), p.2302-2316
Hauptverfasser:	Nguyen, Trang V., Yuan, Lijuan, P. Azevedo, Marli S., Jeong, Kwang-il, Gonzalez, Ana M., Iosef, Cristiana, Lovgren-Bengtsson, Karin, Morein, Bror, Lewis, Peggy, Saif, Linda J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Age Animals Antibodies, Viral - biosynthesis Applied microbiology B cell responses B-Lymphocytes - immunology Biological and medical sciences Clinical trials Developing countries Diarrhea Fundamental and applied biological sciences. Psychology Gnotobiotic pigs Hogs Human rotavirus Humans Immune system Immunity, Maternally-Acquired Immunogenicity Immunologic Memory Immunostimulating complexes Injections, Intraperitoneal ISCOM ISCOMs - administration & dosage LDCs Low titer Maternal antibodies Membrane filters Microbiology Miscellaneous R&D Research & development Rotavirus Rotavirus Vaccines - immunology Swine Vaccine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Attenuated - immunology Virion - immunology Virology Virus Shedding Virus-like particles Viruses VLP
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