Intracellular adhesion molecule concentrations in women who smoke during pregnancy

Smoking and endothelial dysfunction are associated with adverse pregnancy outcomes. The effect of smoking on vascular endothelium during pregnancy has not been well studied. Our objectives were to determine if smoking has an impact on endothelial function in pregnancy by comparing markers of endothe...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Obstetrics and gynecology (New York. 1953) 2006-03, Vol.107 (3), p.588-594
Hauptverfasser: LAIN, Kristine Y, LUPPI, Patrizia, MCGONIGAL, Stacy, ROBERTS, James M, DELOIA, Julie A
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 594
container_issue 3
container_start_page 588
container_title Obstetrics and gynecology (New York. 1953)
container_volume 107
creator LAIN, Kristine Y
LUPPI, Patrizia
MCGONIGAL, Stacy
ROBERTS, James M
DELOIA, Julie A
description Smoking and endothelial dysfunction are associated with adverse pregnancy outcomes. The effect of smoking on vascular endothelium during pregnancy has not been well studied. Our objectives were to determine if smoking has an impact on endothelial function in pregnancy by comparing markers of endothelial function and to evaluate the contribution from different cellular sources. We measured markers of endothelial function in a prospective cohort of 198 primiparous women who had 325 plasma samples obtained throughout pregnancy. Samples were assayed for intracellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin. Smoking status was determined by serum cotinine concentration. Analyses of adhesion molecules were performed for 4 gestational age intervals by using Mann-Whitney and Kruskal-Wallis tests. Gene expression for ICAM-1 was determined by real-time polymerase chain reaction from placental biopsies. A human umbilical vein endothelial cell (HUVEC) culture model was utilized to evaluate the effect of cotinine on endothelial cell production of ICAM-1. ICAM-1 is increased, VCAM-1 was not different, and E-selectin was decreased among smokers at various times during pregnancy. Placental production of ICAM-1 was decreased in women who smoked (P = .02) as measured by real-time polymerase chain reaction. Human umbilical vein endothelial cells production of ICAM-1 increased with heavy concentrations of cotinine exposure (P < .01). Smoking during pregnancy is associated with vascular perturbations, as evidenced by increased concentrations of serum ICAM-1. It appears unlikely that the source of the increased ICAM-1 is the placenta. The endothelium most likely contributes to increased maternal ICAM-1 in heavy smokers, but a leukocyte source cannot be ruled out. II-2.
doi_str_mv 10.1097/01.AOG.0000198628.43211.fc
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67705855</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67705855</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-704f856a080dcc24960f9ffde056ac35fd09f0fd2691fd194e63c3ae560400143</originalsourceid><addsrcrecordid>eNpFkN9LwzAQgIMobk7_BSmCvrVeml-NbzJ0CsJAFHwLMU1ctW1m0iL-92ZusHu4g-O7O-5D6AJDgUGKa8DF7XJRQAosK15WBSUlxoUzB2iKK0HykpC3QzQFKGUuKkon6CTGzw3PJTlGE8wZCFnKKXp-7IegjW3bsdUh0_XKxsb3Wedba8bWZsb3xm6YIbVj1vTZj-9syiufxc5_2aweQ9N_ZOtgP3rdm99TdOR0G-3Zrs7Q6_3dy_whf1ouHue3T7khVAy5AOoqxjVUUBtTUsnBSedqC6lpCHM1SAeuLrnErsaSWk4M0ZZxoOkRSmboart3Hfz3aOOguiZuPtG99WNUXAhgFWMJvNmCJvgYg3VqHZpOh1-FQW2MKsAqGVV7o-rfqHImDZ_vrozvna33ozuFCbjcAToa3bqQHDRxzwnGeEmB_AEmL4DV</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67705855</pqid></control><display><type>article</type><title>Intracellular adhesion molecule concentrations in women who smoke during pregnancy</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>LAIN, Kristine Y ; LUPPI, Patrizia ; MCGONIGAL, Stacy ; ROBERTS, James M ; DELOIA, Julie A</creator><creatorcontrib>LAIN, Kristine Y ; LUPPI, Patrizia ; MCGONIGAL, Stacy ; ROBERTS, James M ; DELOIA, Julie A</creatorcontrib><description>Smoking and endothelial dysfunction are associated with adverse pregnancy outcomes. The effect of smoking on vascular endothelium during pregnancy has not been well studied. Our objectives were to determine if smoking has an impact on endothelial function in pregnancy by comparing markers of endothelial function and to evaluate the contribution from different cellular sources. We measured markers of endothelial function in a prospective cohort of 198 primiparous women who had 325 plasma samples obtained throughout pregnancy. Samples were assayed for intracellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin. Smoking status was determined by serum cotinine concentration. Analyses of adhesion molecules were performed for 4 gestational age intervals by using Mann-Whitney and Kruskal-Wallis tests. Gene expression for ICAM-1 was determined by real-time polymerase chain reaction from placental biopsies. A human umbilical vein endothelial cell (HUVEC) culture model was utilized to evaluate the effect of cotinine on endothelial cell production of ICAM-1. ICAM-1 is increased, VCAM-1 was not different, and E-selectin was decreased among smokers at various times during pregnancy. Placental production of ICAM-1 was decreased in women who smoked (P = .02) as measured by real-time polymerase chain reaction. Human umbilical vein endothelial cells production of ICAM-1 increased with heavy concentrations of cotinine exposure (P &lt; .01). Smoking during pregnancy is associated with vascular perturbations, as evidenced by increased concentrations of serum ICAM-1. It appears unlikely that the source of the increased ICAM-1 is the placenta. The endothelium most likely contributes to increased maternal ICAM-1 in heavy smokers, but a leukocyte source cannot be ruled out. II-2.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>DOI: 10.1097/01.AOG.0000198628.43211.fc</identifier><identifier>PMID: 16507929</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Science</publisher><subject>Adult ; Biological and medical sciences ; Cells, Cultured ; Cotinine - blood ; Endothelium, Vascular - metabolism ; Endothelium, Vascular - physiopathology ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Intercellular Adhesion Molecule-1 - blood ; Intercellular Adhesion Molecule-1 - metabolism ; Medical sciences ; Placenta - metabolism ; Pregnancy - blood ; Prospective Studies ; Smoking - blood ; Smoking - physiopathology ; Umbilical Veins - metabolism</subject><ispartof>Obstetrics and gynecology (New York. 1953), 2006-03, Vol.107 (3), p.588-594</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-704f856a080dcc24960f9ffde056ac35fd09f0fd2691fd194e63c3ae560400143</citedby><cites>FETCH-LOGICAL-c347t-704f856a080dcc24960f9ffde056ac35fd09f0fd2691fd194e63c3ae560400143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=17556240$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16507929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LAIN, Kristine Y</creatorcontrib><creatorcontrib>LUPPI, Patrizia</creatorcontrib><creatorcontrib>MCGONIGAL, Stacy</creatorcontrib><creatorcontrib>ROBERTS, James M</creatorcontrib><creatorcontrib>DELOIA, Julie A</creatorcontrib><title>Intracellular adhesion molecule concentrations in women who smoke during pregnancy</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>Smoking and endothelial dysfunction are associated with adverse pregnancy outcomes. The effect of smoking on vascular endothelium during pregnancy has not been well studied. Our objectives were to determine if smoking has an impact on endothelial function in pregnancy by comparing markers of endothelial function and to evaluate the contribution from different cellular sources. We measured markers of endothelial function in a prospective cohort of 198 primiparous women who had 325 plasma samples obtained throughout pregnancy. Samples were assayed for intracellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin. Smoking status was determined by serum cotinine concentration. Analyses of adhesion molecules were performed for 4 gestational age intervals by using Mann-Whitney and Kruskal-Wallis tests. Gene expression for ICAM-1 was determined by real-time polymerase chain reaction from placental biopsies. A human umbilical vein endothelial cell (HUVEC) culture model was utilized to evaluate the effect of cotinine on endothelial cell production of ICAM-1. ICAM-1 is increased, VCAM-1 was not different, and E-selectin was decreased among smokers at various times during pregnancy. Placental production of ICAM-1 was decreased in women who smoked (P = .02) as measured by real-time polymerase chain reaction. Human umbilical vein endothelial cells production of ICAM-1 increased with heavy concentrations of cotinine exposure (P &lt; .01). Smoking during pregnancy is associated with vascular perturbations, as evidenced by increased concentrations of serum ICAM-1. It appears unlikely that the source of the increased ICAM-1 is the placenta. The endothelium most likely contributes to increased maternal ICAM-1 in heavy smokers, but a leukocyte source cannot be ruled out. II-2.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Cotinine - blood</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Intercellular Adhesion Molecule-1 - blood</subject><subject>Intercellular Adhesion Molecule-1 - metabolism</subject><subject>Medical sciences</subject><subject>Placenta - metabolism</subject><subject>Pregnancy - blood</subject><subject>Prospective Studies</subject><subject>Smoking - blood</subject><subject>Smoking - physiopathology</subject><subject>Umbilical Veins - metabolism</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkN9LwzAQgIMobk7_BSmCvrVeml-NbzJ0CsJAFHwLMU1ctW1m0iL-92ZusHu4g-O7O-5D6AJDgUGKa8DF7XJRQAosK15WBSUlxoUzB2iKK0HykpC3QzQFKGUuKkon6CTGzw3PJTlGE8wZCFnKKXp-7IegjW3bsdUh0_XKxsb3Wedba8bWZsb3xm6YIbVj1vTZj-9syiufxc5_2aweQ9N_ZOtgP3rdm99TdOR0G-3Zrs7Q6_3dy_whf1ouHue3T7khVAy5AOoqxjVUUBtTUsnBSedqC6lpCHM1SAeuLrnErsaSWk4M0ZZxoOkRSmboart3Hfz3aOOguiZuPtG99WNUXAhgFWMJvNmCJvgYg3VqHZpOh1-FQW2MKsAqGVV7o-rfqHImDZ_vrozvna33ozuFCbjcAToa3bqQHDRxzwnGeEmB_AEmL4DV</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>LAIN, Kristine Y</creator><creator>LUPPI, Patrizia</creator><creator>MCGONIGAL, Stacy</creator><creator>ROBERTS, James M</creator><creator>DELOIA, Julie A</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060301</creationdate><title>Intracellular adhesion molecule concentrations in women who smoke during pregnancy</title><author>LAIN, Kristine Y ; LUPPI, Patrizia ; MCGONIGAL, Stacy ; ROBERTS, James M ; DELOIA, Julie A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-704f856a080dcc24960f9ffde056ac35fd09f0fd2691fd194e63c3ae560400143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Cotinine - blood</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Intercellular Adhesion Molecule-1 - blood</topic><topic>Intercellular Adhesion Molecule-1 - metabolism</topic><topic>Medical sciences</topic><topic>Placenta - metabolism</topic><topic>Pregnancy - blood</topic><topic>Prospective Studies</topic><topic>Smoking - blood</topic><topic>Smoking - physiopathology</topic><topic>Umbilical Veins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LAIN, Kristine Y</creatorcontrib><creatorcontrib>LUPPI, Patrizia</creatorcontrib><creatorcontrib>MCGONIGAL, Stacy</creatorcontrib><creatorcontrib>ROBERTS, James M</creatorcontrib><creatorcontrib>DELOIA, Julie A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LAIN, Kristine Y</au><au>LUPPI, Patrizia</au><au>MCGONIGAL, Stacy</au><au>ROBERTS, James M</au><au>DELOIA, Julie A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracellular adhesion molecule concentrations in women who smoke during pregnancy</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>107</volume><issue>3</issue><spage>588</spage><epage>594</epage><pages>588-594</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>Smoking and endothelial dysfunction are associated with adverse pregnancy outcomes. The effect of smoking on vascular endothelium during pregnancy has not been well studied. Our objectives were to determine if smoking has an impact on endothelial function in pregnancy by comparing markers of endothelial function and to evaluate the contribution from different cellular sources. We measured markers of endothelial function in a prospective cohort of 198 primiparous women who had 325 plasma samples obtained throughout pregnancy. Samples were assayed for intracellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin. Smoking status was determined by serum cotinine concentration. Analyses of adhesion molecules were performed for 4 gestational age intervals by using Mann-Whitney and Kruskal-Wallis tests. Gene expression for ICAM-1 was determined by real-time polymerase chain reaction from placental biopsies. A human umbilical vein endothelial cell (HUVEC) culture model was utilized to evaluate the effect of cotinine on endothelial cell production of ICAM-1. ICAM-1 is increased, VCAM-1 was not different, and E-selectin was decreased among smokers at various times during pregnancy. Placental production of ICAM-1 was decreased in women who smoked (P = .02) as measured by real-time polymerase chain reaction. Human umbilical vein endothelial cells production of ICAM-1 increased with heavy concentrations of cotinine exposure (P &lt; .01). Smoking during pregnancy is associated with vascular perturbations, as evidenced by increased concentrations of serum ICAM-1. It appears unlikely that the source of the increased ICAM-1 is the placenta. The endothelium most likely contributes to increased maternal ICAM-1 in heavy smokers, but a leukocyte source cannot be ruled out. II-2.</abstract><cop>New York, NY</cop><pub>Elsevier Science</pub><pmid>16507929</pmid><doi>10.1097/01.AOG.0000198628.43211.fc</doi><tpages>7</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0029-7844
ispartof Obstetrics and gynecology (New York. 1953), 2006-03, Vol.107 (3), p.588-594
issn 0029-7844
1873-233X
language eng
recordid cdi_proquest_miscellaneous_67705855
source MEDLINE; Journals@Ovid Complete
subjects Adult
Biological and medical sciences
Cells, Cultured
Cotinine - blood
Endothelium, Vascular - metabolism
Endothelium, Vascular - physiopathology
Female
Gynecology. Andrology. Obstetrics
Humans
Intercellular Adhesion Molecule-1 - blood
Intercellular Adhesion Molecule-1 - metabolism
Medical sciences
Placenta - metabolism
Pregnancy - blood
Prospective Studies
Smoking - blood
Smoking - physiopathology
Umbilical Veins - metabolism
title Intracellular adhesion molecule concentrations in women who smoke during pregnancy
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T23%3A36%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intracellular%20adhesion%20molecule%20concentrations%20in%20women%20who%20smoke%20during%20pregnancy&rft.jtitle=Obstetrics%20and%20gynecology%20(New%20York.%201953)&rft.au=LAIN,%20Kristine%20Y&rft.date=2006-03-01&rft.volume=107&rft.issue=3&rft.spage=588&rft.epage=594&rft.pages=588-594&rft.issn=0029-7844&rft.eissn=1873-233X&rft.coden=OBGNAS&rft_id=info:doi/10.1097/01.AOG.0000198628.43211.fc&rft_dat=%3Cproquest_cross%3E67705855%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67705855&rft_id=info:pmid/16507929&rfr_iscdi=true