The pheomelanin precursor 5- S-cysteinyldopa protects melanocytes from membrane damage induced by ultraviolet A radiation
Pheomelanin and pheomelanin precursors have been implicated as risk factors for induction of melanoma by ultraviolet radiation. The pheomelanin precursor, 5- S-cysteinyldopa, has been shown to sensitise DNA to oxidative damage by ultraviolet radiation. We here show that 5- S-cysteinyldopa significan...
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| Veröffentlicht in: | Cancer letters 2005-04, Vol.221 (2), p.131-134 |
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| container_end_page | 134 |
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| container_issue | 2 |
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| container_title | Cancer letters |
| container_volume | 221 |
| creator | Kvam, Egil Dahle, Jostein |
| description | Pheomelanin and pheomelanin precursors have been implicated as risk factors for induction of melanoma by ultraviolet radiation. The pheomelanin precursor, 5-
S-cysteinyldopa, has been shown to sensitise DNA to oxidative damage by ultraviolet radiation. We here show that 5-
S-cysteinyldopa significantly protects melanocytes from membrane damage (permeability) induced by ultraviolet A radiation. Thus, 5-
S-cysteinyldopa, may at the same time sensitise DNA and protect membranes from damage induced by ultraviolet radiation. |
| doi_str_mv | 10.1016/j.canlet.2004.08.025 |
| format | Article |
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S-cysteinyldopa, has been shown to sensitise DNA to oxidative damage by ultraviolet radiation. We here show that 5-
S-cysteinyldopa significantly protects melanocytes from membrane damage (permeability) induced by ultraviolet A radiation. Thus, 5-
S-cysteinyldopa, may at the same time sensitise DNA and protect membranes from damage induced by ultraviolet radiation.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2004.08.025</identifier><identifier>PMID: 15808398</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Cell Membrane - drug effects ; Cell Membrane - metabolism ; Cell Membrane - radiation effects ; Cells, Cultured - drug effects ; Cells, Cultured - radiation effects ; Cysteinyldopa ; Cysteinyldopa - pharmacology ; Deoxyribonucleic acid ; DNA ; DNA Damage ; Flow cytometry ; Lipid peroxidation ; Lipids ; Melanins - metabolism ; Melanocyte ; Melanocytes - drug effects ; Melanocytes - radiation effects ; Melanoma ; Membrane damage ; Membranes ; Mice ; Permeability ; Radiation-Protective Agents - pharmacology ; Skin cancer ; Ultraviolet A ; Ultraviolet radiation ; Ultraviolet Rays</subject><ispartof>Cancer letters, 2005-04, Vol.221 (2), p.131-134</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>Copyright Elsevier Limited Apr 28, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-8b1c5b78d0171981c583815192edf356a786421460592c190e276a6fe01ed4d53</citedby><cites>FETCH-LOGICAL-c388t-8b1c5b78d0171981c583815192edf356a786421460592c190e276a6fe01ed4d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2004.08.025$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15808398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kvam, Egil</creatorcontrib><creatorcontrib>Dahle, Jostein</creatorcontrib><title>The pheomelanin precursor 5- S-cysteinyldopa protects melanocytes from membrane damage induced by ultraviolet A radiation</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Pheomelanin and pheomelanin precursors have been implicated as risk factors for induction of melanoma by ultraviolet radiation. The pheomelanin precursor, 5-
S-cysteinyldopa, has been shown to sensitise DNA to oxidative damage by ultraviolet radiation. We here show that 5-
S-cysteinyldopa significantly protects melanocytes from membrane damage (permeability) induced by ultraviolet A radiation. Thus, 5-
S-cysteinyldopa, may at the same time sensitise DNA and protect membranes from damage induced by ultraviolet radiation.</description><subject>Animals</subject><subject>Cell Membrane - drug effects</subject><subject>Cell Membrane - metabolism</subject><subject>Cell Membrane - radiation effects</subject><subject>Cells, Cultured - drug effects</subject><subject>Cells, Cultured - radiation effects</subject><subject>Cysteinyldopa</subject><subject>Cysteinyldopa - pharmacology</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Damage</subject><subject>Flow cytometry</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Melanins - metabolism</subject><subject>Melanocyte</subject><subject>Melanocytes - drug effects</subject><subject>Melanocytes - radiation effects</subject><subject>Melanoma</subject><subject>Membrane damage</subject><subject>Membranes</subject><subject>Mice</subject><subject>Permeability</subject><subject>Radiation-Protective Agents - pharmacology</subject><subject>Skin cancer</subject><subject>Ultraviolet A</subject><subject>Ultraviolet radiation</subject><subject>Ultraviolet Rays</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGL1DAUx4Mo7rj6DUQCgrd2X5qmSS_CsrirsLAH13NIk1c3Q9uMSbrQb2_GGRA8eApJfu_ln_cj5D2DmgHrrva1NcuEuW4A2hpUDY14QXZMyaaSvYKXZAcc2oorLi7Im5T2ACBaKV6TCyYUKN6rHdken5AenjDMOJnFL_QQ0a4xhUhFRb9XdksZ_bJNLhxMuQwZbU70Dx3sljHRMYa5HMxDNAtSZ2bzE6lf3GrR0WGj65SjefahZKXXNBrnTfZheUtejWZK-O68XpIft18eb75W9w93326u7yvLlcqVGpgVg1QOmGS9KhvFFROsb9CNXHRGqq5tWNuB6BvLesBGdqYbERi61gl-ST6d-pbwv1ZMWc8-WZzKBzCsSXdSguA9L-DHf8B9WONSsmkmCtL1vTy2a0-UjSGliKM-RD-buGkG-ihG7_VJjD6K0aB0EVPKPpybr8OM7m_R2UQBPp8ALLN49hh1sh6XMkNfjGTtgv__C78BOfehGg</recordid><startdate>20050428</startdate><enddate>20050428</enddate><creator>Kvam, Egil</creator><creator>Dahle, Jostein</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20050428</creationdate><title>The pheomelanin precursor 5- S-cysteinyldopa protects melanocytes from membrane damage induced by ultraviolet A radiation</title><author>Kvam, Egil ; Dahle, Jostein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-8b1c5b78d0171981c583815192edf356a786421460592c190e276a6fe01ed4d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Cell Membrane - drug effects</topic><topic>Cell Membrane - metabolism</topic><topic>Cell Membrane - radiation effects</topic><topic>Cells, Cultured - drug effects</topic><topic>Cells, Cultured - radiation effects</topic><topic>Cysteinyldopa</topic><topic>Cysteinyldopa - pharmacology</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA Damage</topic><topic>Flow cytometry</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Melanins - metabolism</topic><topic>Melanocyte</topic><topic>Melanocytes - drug effects</topic><topic>Melanocytes - radiation effects</topic><topic>Melanoma</topic><topic>Membrane damage</topic><topic>Membranes</topic><topic>Mice</topic><topic>Permeability</topic><topic>Radiation-Protective Agents - pharmacology</topic><topic>Skin cancer</topic><topic>Ultraviolet A</topic><topic>Ultraviolet radiation</topic><topic>Ultraviolet Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kvam, Egil</creatorcontrib><creatorcontrib>Dahle, Jostein</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kvam, Egil</au><au>Dahle, Jostein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The pheomelanin precursor 5- S-cysteinyldopa protects melanocytes from membrane damage induced by ultraviolet A radiation</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2005-04-28</date><risdate>2005</risdate><volume>221</volume><issue>2</issue><spage>131</spage><epage>134</epage><pages>131-134</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Pheomelanin and pheomelanin precursors have been implicated as risk factors for induction of melanoma by ultraviolet radiation. The pheomelanin precursor, 5-
S-cysteinyldopa, has been shown to sensitise DNA to oxidative damage by ultraviolet radiation. We here show that 5-
S-cysteinyldopa significantly protects melanocytes from membrane damage (permeability) induced by ultraviolet A radiation. Thus, 5-
S-cysteinyldopa, may at the same time sensitise DNA and protect membranes from damage induced by ultraviolet radiation.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>15808398</pmid><doi>10.1016/j.canlet.2004.08.025</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2005-04, Vol.221 (2), p.131-134 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cell Membrane - drug effects Cell Membrane - metabolism Cell Membrane - radiation effects Cells, Cultured - drug effects Cells, Cultured - radiation effects Cysteinyldopa Cysteinyldopa - pharmacology Deoxyribonucleic acid DNA DNA Damage Flow cytometry Lipid peroxidation Lipids Melanins - metabolism Melanocyte Melanocytes - drug effects Melanocytes - radiation effects Melanoma Membrane damage Membranes Mice Permeability Radiation-Protective Agents - pharmacology Skin cancer Ultraviolet A Ultraviolet radiation Ultraviolet Rays |
| title | The pheomelanin precursor 5- S-cysteinyldopa protects melanocytes from membrane damage induced by ultraviolet A radiation |
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