Xenotransplantation of neonatal porcine islets and Sertoli cells into nonimmunosuppressed streptozotocin-induced diabetic rats
The testis has been shown to be a privileged site for transplantation of allogenic islets in rodents, and the testicular cell aggregates are thought to confer this immunologic privilege. Recently, a group in Mexico reported transplantation of cocultured neonatal porcine islets and Sertoli cells resu...
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| Veröffentlicht in: | Transplantation proceedings 2005, Vol.37 (1), p.470-471 |
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| container_title | Transplantation proceedings |
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| creator | Wang, D.Z. Skinner, S. Elliot, R. Escobar, L. Salto-Tellez, M. Garkavenko, O. Khoo, A. Lee, K.O. Calne, R. Isaac, J.R. |
| description | The testis has been shown to be a privileged site for transplantation of allogenic islets in rodents, and the testicular cell aggregates are thought to confer this immunologic privilege. Recently, a group in Mexico reported transplantation of cocultured neonatal porcine islets and Sertoli cells resulting in insulin independence in nonimmunosuppressed type 1 diabetes patients. We have transplanted similar islets alone (naked islets) or cocultured islets with Sertoli cells (islet/Sertoli cells) into an omental site and other locations of nonimmunosuppressed, streptozotocin-induced diabetic male Sprague Dawley (SD) rats. Histologic examination showed viable neonatal porcine islets survived in xenografted rodents for at least 2 days, and some glucagon and inhibin stained cells appear to have survived for 4 days posttransplantation. However, histological examination did not demonstrate any difference in xenograft survival in the islets/Sertoli cells mixture compared to naked islets when transplanted into these nonimmunosuppressed diabetic rats. |
| doi_str_mv | 10.1016/j.transproceed.2004.11.057 |
| format | Article |
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Recently, a group in Mexico reported transplantation of cocultured neonatal porcine islets and Sertoli cells resulting in insulin independence in nonimmunosuppressed type 1 diabetes patients. We have transplanted similar islets alone (naked islets) or cocultured islets with Sertoli cells (islet/Sertoli cells) into an omental site and other locations of nonimmunosuppressed, streptozotocin-induced diabetic male Sprague Dawley (SD) rats. Histologic examination showed viable neonatal porcine islets survived in xenografted rodents for at least 2 days, and some glucagon and inhibin stained cells appear to have survived for 4 days posttransplantation. However, histological examination did not demonstrate any difference in xenograft survival in the islets/Sertoli cells mixture compared to naked islets when transplanted into these nonimmunosuppressed diabetic rats.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2004.11.057</identifier><identifier>PMID: 15808679</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Animals, Newborn ; Cells, Cultured ; Coculture Techniques ; Diabetes Mellitus, Experimental - surgery ; Glucagon - metabolism ; Immunohistochemistry ; Inhibins - metabolism ; Islets of Langerhans ; Islets of Langerhans Transplantation - pathology ; Male ; Rats ; Sertoli Cells - cytology ; Sertoli Cells - transplantation ; Swine ; Time Factors ; Transplantation, Heterologous - pathology</subject><ispartof>Transplantation proceedings, 2005, Vol.37 (1), p.470-471</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-c9cd77e362f46a7b341da2556d0ede88587b7b3e2ae61b611e648ed7dab10f5c3</citedby><cites>FETCH-LOGICAL-c378t-c9cd77e362f46a7b341da2556d0ede88587b7b3e2ae61b611e648ed7dab10f5c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.transproceed.2004.11.057$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,4012,27912,27913,27914,45984</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15808679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, D.Z.</creatorcontrib><creatorcontrib>Skinner, S.</creatorcontrib><creatorcontrib>Elliot, R.</creatorcontrib><creatorcontrib>Escobar, L.</creatorcontrib><creatorcontrib>Salto-Tellez, M.</creatorcontrib><creatorcontrib>Garkavenko, O.</creatorcontrib><creatorcontrib>Khoo, A.</creatorcontrib><creatorcontrib>Lee, K.O.</creatorcontrib><creatorcontrib>Calne, R.</creatorcontrib><creatorcontrib>Isaac, J.R.</creatorcontrib><title>Xenotransplantation of neonatal porcine islets and Sertoli cells into nonimmunosuppressed streptozotocin-induced diabetic rats</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>The testis has been shown to be a privileged site for transplantation of allogenic islets in rodents, and the testicular cell aggregates are thought to confer this immunologic privilege. Recently, a group in Mexico reported transplantation of cocultured neonatal porcine islets and Sertoli cells resulting in insulin independence in nonimmunosuppressed type 1 diabetes patients. We have transplanted similar islets alone (naked islets) or cocultured islets with Sertoli cells (islet/Sertoli cells) into an omental site and other locations of nonimmunosuppressed, streptozotocin-induced diabetic male Sprague Dawley (SD) rats. Histologic examination showed viable neonatal porcine islets survived in xenografted rodents for at least 2 days, and some glucagon and inhibin stained cells appear to have survived for 4 days posttransplantation. However, histological examination did not demonstrate any difference in xenograft survival in the islets/Sertoli cells mixture compared to naked islets when transplanted into these nonimmunosuppressed diabetic rats.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Cells, Cultured</subject><subject>Coculture Techniques</subject><subject>Diabetes Mellitus, Experimental - surgery</subject><subject>Glucagon - metabolism</subject><subject>Immunohistochemistry</subject><subject>Inhibins - metabolism</subject><subject>Islets of Langerhans</subject><subject>Islets of Langerhans Transplantation - pathology</subject><subject>Male</subject><subject>Rats</subject><subject>Sertoli Cells - cytology</subject><subject>Sertoli Cells - transplantation</subject><subject>Swine</subject><subject>Time Factors</subject><subject>Transplantation, Heterologous - pathology</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE2LFDEQhoMo7rj6FyR48NZtqj-SrDfZ9QsWPKjgLaSTasjQnbSptKAHf7sZZhCPnoqqeuutqoexFyBaECBfHduSbaQtJ4fo206IoQVoxagesANo1Ted7PqH7FAb0EA_jFfsCdFR1Lwb-sfsCkYttFQ3B_b7G8Z0tltsLLaEFHmaecQUbbEL31J2ISIPtGAhbqPnnzGXtATucFmIh1gSjymGdd1jon3bMhKh51QybiX9SiVVhyZEv7ta9sFOWILj2RZ6yh7NdiF8donX7Ou7t19uPzT3n95_vH1z37he6dK4G-eVwl528yCtmvoBvO3GUXqBHrUetZpqFTuLEiYJgHLQ6JW3E4h5dP01e3n2rdC-70jFrIFO99v66E5GKiUGpccqfH0WupyIMs5my2G1-acBYU70zdH8S9-c6BsAU-nX4eeXLfu01t7f0QvuKrg7C7D--iNgNuQCxoolZHTF-BT-Z88fwcWinA</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Wang, D.Z.</creator><creator>Skinner, S.</creator><creator>Elliot, R.</creator><creator>Escobar, L.</creator><creator>Salto-Tellez, M.</creator><creator>Garkavenko, O.</creator><creator>Khoo, A.</creator><creator>Lee, K.O.</creator><creator>Calne, R.</creator><creator>Isaac, J.R.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2005</creationdate><title>Xenotransplantation of neonatal porcine islets and Sertoli cells into nonimmunosuppressed streptozotocin-induced diabetic rats</title><author>Wang, D.Z. ; Skinner, S. ; Elliot, R. ; Escobar, L. ; Salto-Tellez, M. ; Garkavenko, O. ; Khoo, A. ; Lee, K.O. ; Calne, R. ; Isaac, J.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-c9cd77e362f46a7b341da2556d0ede88587b7b3e2ae61b611e648ed7dab10f5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Cells, Cultured</topic><topic>Coculture Techniques</topic><topic>Diabetes Mellitus, Experimental - surgery</topic><topic>Glucagon - metabolism</topic><topic>Immunohistochemistry</topic><topic>Inhibins - metabolism</topic><topic>Islets of Langerhans</topic><topic>Islets of Langerhans Transplantation - pathology</topic><topic>Male</topic><topic>Rats</topic><topic>Sertoli Cells - cytology</topic><topic>Sertoli Cells - transplantation</topic><topic>Swine</topic><topic>Time Factors</topic><topic>Transplantation, Heterologous - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, D.Z.</creatorcontrib><creatorcontrib>Skinner, S.</creatorcontrib><creatorcontrib>Elliot, R.</creatorcontrib><creatorcontrib>Escobar, L.</creatorcontrib><creatorcontrib>Salto-Tellez, M.</creatorcontrib><creatorcontrib>Garkavenko, O.</creatorcontrib><creatorcontrib>Khoo, A.</creatorcontrib><creatorcontrib>Lee, K.O.</creatorcontrib><creatorcontrib>Calne, R.</creatorcontrib><creatorcontrib>Isaac, J.R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, D.Z.</au><au>Skinner, S.</au><au>Elliot, R.</au><au>Escobar, L.</au><au>Salto-Tellez, M.</au><au>Garkavenko, O.</au><au>Khoo, A.</au><au>Lee, K.O.</au><au>Calne, R.</au><au>Isaac, J.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Xenotransplantation of neonatal porcine islets and Sertoli cells into nonimmunosuppressed streptozotocin-induced diabetic rats</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2005</date><risdate>2005</risdate><volume>37</volume><issue>1</issue><spage>470</spage><epage>471</epage><pages>470-471</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><abstract>The testis has been shown to be a privileged site for transplantation of allogenic islets in rodents, and the testicular cell aggregates are thought to confer this immunologic privilege. Recently, a group in Mexico reported transplantation of cocultured neonatal porcine islets and Sertoli cells resulting in insulin independence in nonimmunosuppressed type 1 diabetes patients. We have transplanted similar islets alone (naked islets) or cocultured islets with Sertoli cells (islet/Sertoli cells) into an omental site and other locations of nonimmunosuppressed, streptozotocin-induced diabetic male Sprague Dawley (SD) rats. Histologic examination showed viable neonatal porcine islets survived in xenografted rodents for at least 2 days, and some glucagon and inhibin stained cells appear to have survived for 4 days posttransplantation. However, histological examination did not demonstrate any difference in xenograft survival in the islets/Sertoli cells mixture compared to naked islets when transplanted into these nonimmunosuppressed diabetic rats.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15808679</pmid><doi>10.1016/j.transproceed.2004.11.057</doi><tpages>2</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Animals, Newborn Cells, Cultured Coculture Techniques Diabetes Mellitus, Experimental - surgery Glucagon - metabolism Immunohistochemistry Inhibins - metabolism Islets of Langerhans Islets of Langerhans Transplantation - pathology Male Rats Sertoli Cells - cytology Sertoli Cells - transplantation Swine Time Factors Transplantation, Heterologous - pathology |
| title | Xenotransplantation of neonatal porcine islets and Sertoli cells into nonimmunosuppressed streptozotocin-induced diabetic rats |
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