The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells
As an effort to identify immune suppressive molecules in gastric cancer cells, a signal sequence trap was employed. Among the genes identified, 9-27 gene was highly expressed in gastric tumor tissues and in cancer cell lines. It was induced by IFN-γ treatment, but not by TNF-α or TGF-β1 treatment. T...
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| Veröffentlicht in: | Cancer letters 2005-04, Vol.221 (2), p.191-200 |
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| container_title | Cancer letters |
| container_volume | 221 |
| creator | Yang, Young Lee, Jeong-Hyung Yong Kim, Kun Keun Song, Hyun Kwang Kim, Jae Ran Yoon, Suk Cho, Daeho Sang Song, Kyu Ho Lee, Young Choi, Inpyo |
| description | As an effort to identify immune suppressive molecules in gastric cancer cells, a signal sequence trap was employed. Among the genes identified, 9-27 gene was highly expressed in gastric tumor tissues and in cancer cell lines. It was induced by IFN-γ treatment, but not by TNF-α or TGF-β1 treatment. The overexpression of 9-27 in the gastric cancer cells rendered tumor cells more resistant to natural killer cells. In addition, the 9-27-overexpressed cells showed an increased migration and an invasive capacity when compared with the control cells. Taken together, these data indicate that 9-27 plays a role in malignant progression by suppressing natural killer cells and by increasing the invasive potential of gastric cancer cells. |
| doi_str_mv | 10.1016/j.canlet.2004.08.022 |
| format | Article |
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Among the genes identified, 9-27 gene was highly expressed in gastric tumor tissues and in cancer cell lines. It was induced by IFN-γ treatment, but not by TNF-α or TGF-β1 treatment. The overexpression of 9-27 in the gastric cancer cells rendered tumor cells more resistant to natural killer cells. In addition, the 9-27-overexpressed cells showed an increased migration and an invasive capacity when compared with the control cells. Taken together, these data indicate that 9-27 plays a role in malignant progression by suppressing natural killer cells and by increasing the invasive potential of gastric cancer cells.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2004.08.022</identifier><identifier>PMID: 15808405</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>9-27 ; Adenocarcinoma - immunology ; Adenocarcinoma - therapy ; Antigens, Differentiation ; Antineoplastic Agents - pharmacology ; Cell Movement - drug effects ; Cloning ; Gastric cancer ; Gene expression ; Gene Expression Profiling ; Humans ; Hybridization ; IFN-γ ; Interferon-gamma - pharmacology ; Invasion ; Killer Cells, Natural - drug effects ; Kinases ; Leukemia ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Natural killer cell ; Neoplasm Invasiveness - pathology ; Proteins ; Stomach Neoplasms - immunology ; Stomach Neoplasms - therapy ; Transforming Growth Factor beta - pharmacology ; Transforming Growth Factor beta1 ; Tumor Cells, Cultured - drug effects ; Tumor Necrosis Factor-alpha - pharmacology ; Tumors</subject><ispartof>Cancer letters, 2005-04, Vol.221 (2), p.191-200</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>Copyright Elsevier Limited Apr 28, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-59782e7ac216b5e936a24484f83da0a029efabe15ef74f59f0facf9bdacc008a3</citedby><cites>FETCH-LOGICAL-c388t-59782e7ac216b5e936a24484f83da0a029efabe15ef74f59f0facf9bdacc008a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2004.08.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15808405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Young</creatorcontrib><creatorcontrib>Lee, Jeong-Hyung</creatorcontrib><creatorcontrib>Yong Kim, Kun</creatorcontrib><creatorcontrib>Keun Song, Hyun</creatorcontrib><creatorcontrib>Kwang Kim, Jae</creatorcontrib><creatorcontrib>Ran Yoon, Suk</creatorcontrib><creatorcontrib>Cho, Daeho</creatorcontrib><creatorcontrib>Sang Song, Kyu</creatorcontrib><creatorcontrib>Ho Lee, Young</creatorcontrib><creatorcontrib>Choi, Inpyo</creatorcontrib><title>The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>As an effort to identify immune suppressive molecules in gastric cancer cells, a signal sequence trap was employed. Among the genes identified, 9-27 gene was highly expressed in gastric tumor tissues and in cancer cell lines. It was induced by IFN-γ treatment, but not by TNF-α or TGF-β1 treatment. The overexpression of 9-27 in the gastric cancer cells rendered tumor cells more resistant to natural killer cells. In addition, the 9-27-overexpressed cells showed an increased migration and an invasive capacity when compared with the control cells. Taken together, these data indicate that 9-27 plays a role in malignant progression by suppressing natural killer cells and by increasing the invasive potential of gastric cancer cells.</description><subject>9-27</subject><subject>Adenocarcinoma - immunology</subject><subject>Adenocarcinoma - therapy</subject><subject>Antigens, Differentiation</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Cell Movement - drug effects</subject><subject>Cloning</subject><subject>Gastric cancer</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Humans</subject><subject>Hybridization</subject><subject>IFN-γ</subject><subject>Interferon-gamma - pharmacology</subject><subject>Invasion</subject><subject>Killer Cells, Natural - drug effects</subject><subject>Kinases</subject><subject>Leukemia</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Natural killer cell</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Proteins</subject><subject>Stomach Neoplasms - immunology</subject><subject>Stomach Neoplasms - therapy</subject><subject>Transforming Growth Factor beta - pharmacology</subject><subject>Transforming Growth Factor beta1</subject><subject>Tumor Cells, Cultured - drug effects</subject><subject>Tumor Necrosis Factor-alpha - pharmacology</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcGKFDEQhoMo7uzqG4gEBG_dVrqTTvoiyLK6woKX9RzS6cqaMZMek_TA3n1wM86I4MFTXb7666c-Ql4xaBmw4d22tSYGLG0HwFtQLXTdE7JhSnaNHBU8JRvogTe96sUFucx5CwCCS_GcXDChQHEQG_Lz_htSHwsmh2mJjY_zav0UkI5NJ-kDRqS7ZV6DKZhpqXBes8V98ZMPvjzSstBoyppMoN99CJioxRAyNXH-jft4MNkfak7OdHH0weSSvKW1vP0DvyDPnAkZX57nFfn68eb--ra5-_Lp8_WHu8b2SpVGjFJ1KI3t2DAJHPvBdJwr7lQ_GzDQjejMhEygk9yJ0YEz1o3TbKwFUKa_Im9Pufu0_FgxF73z-djARFzWrAcpgctBVfDNP-B2WVOs3TQTIPphHDmvFD9RNi05J3R6n_zOpEfNQB8d6a0-OdJHRxqUro7q2utz-DrtcP67dJZSgfcnAOsvDh6TztZjfdfsE9qi58X__8Ivb8Smtg</recordid><startdate>20050428</startdate><enddate>20050428</enddate><creator>Yang, Young</creator><creator>Lee, Jeong-Hyung</creator><creator>Yong Kim, Kun</creator><creator>Keun Song, Hyun</creator><creator>Kwang Kim, Jae</creator><creator>Ran Yoon, Suk</creator><creator>Cho, Daeho</creator><creator>Sang Song, Kyu</creator><creator>Ho Lee, Young</creator><creator>Choi, Inpyo</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20050428</creationdate><title>The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells</title><author>Yang, Young ; Lee, Jeong-Hyung ; Yong Kim, Kun ; Keun Song, Hyun ; Kwang Kim, Jae ; Ran Yoon, Suk ; Cho, Daeho ; Sang Song, Kyu ; Ho Lee, Young ; Choi, Inpyo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-59782e7ac216b5e936a24484f83da0a029efabe15ef74f59f0facf9bdacc008a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>9-27</topic><topic>Adenocarcinoma - immunology</topic><topic>Adenocarcinoma - therapy</topic><topic>Antigens, Differentiation</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Cell Movement - drug effects</topic><topic>Cloning</topic><topic>Gastric cancer</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Humans</topic><topic>Hybridization</topic><topic>IFN-γ</topic><topic>Interferon-gamma - pharmacology</topic><topic>Invasion</topic><topic>Killer Cells, Natural - drug effects</topic><topic>Kinases</topic><topic>Leukemia</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Natural killer cell</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Proteins</topic><topic>Stomach Neoplasms - immunology</topic><topic>Stomach Neoplasms - therapy</topic><topic>Transforming Growth Factor beta - pharmacology</topic><topic>Transforming Growth Factor beta1</topic><topic>Tumor Cells, Cultured - drug effects</topic><topic>Tumor Necrosis Factor-alpha - pharmacology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Young</creatorcontrib><creatorcontrib>Lee, Jeong-Hyung</creatorcontrib><creatorcontrib>Yong Kim, Kun</creatorcontrib><creatorcontrib>Keun Song, Hyun</creatorcontrib><creatorcontrib>Kwang Kim, Jae</creatorcontrib><creatorcontrib>Ran Yoon, Suk</creatorcontrib><creatorcontrib>Cho, Daeho</creatorcontrib><creatorcontrib>Sang Song, Kyu</creatorcontrib><creatorcontrib>Ho Lee, Young</creatorcontrib><creatorcontrib>Choi, Inpyo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Young</au><au>Lee, Jeong-Hyung</au><au>Yong Kim, Kun</au><au>Keun Song, Hyun</au><au>Kwang Kim, Jae</au><au>Ran Yoon, Suk</au><au>Cho, Daeho</au><au>Sang Song, Kyu</au><au>Ho Lee, Young</au><au>Choi, Inpyo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2005-04-28</date><risdate>2005</risdate><volume>221</volume><issue>2</issue><spage>191</spage><epage>200</epage><pages>191-200</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>As an effort to identify immune suppressive molecules in gastric cancer cells, a signal sequence trap was employed. 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| ispartof | Cancer letters, 2005-04, Vol.221 (2), p.191-200 |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | 9-27 Adenocarcinoma - immunology Adenocarcinoma - therapy Antigens, Differentiation Antineoplastic Agents - pharmacology Cell Movement - drug effects Cloning Gastric cancer Gene expression Gene Expression Profiling Humans Hybridization IFN-γ Interferon-gamma - pharmacology Invasion Killer Cells, Natural - drug effects Kinases Leukemia Membrane Proteins - genetics Membrane Proteins - metabolism Natural killer cell Neoplasm Invasiveness - pathology Proteins Stomach Neoplasms - immunology Stomach Neoplasms - therapy Transforming Growth Factor beta - pharmacology Transforming Growth Factor beta1 Tumor Cells, Cultured - drug effects Tumor Necrosis Factor-alpha - pharmacology Tumors |
| title | The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells |
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