Anxiolytic-Like Effects of (O-Methyl)-N-2,6-dihydroxybenzoyl-tyramine (Riparin III) from Aniba riparia (NEES) MEZ (Lauraceae) in Mice
This work presents behavioral effects of (O-methyl)-N-2,6-dihydroxybenzoyl-tyramine (riparin III) isolated from the unripe fruit of Aniba riparia (NEES) MEZ (Lauraceae) in animal models of open field, rota rod, elevated plus maze and hole board tests in mice. Riparin III (ripIII) was administered or...
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| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2006, Vol.29(3), pp.451-454 |
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| creator | Carla Thiciane Vasconcelos de Melo Monteiro, Andreisa Paiva Leite, Caroline Porto Fernando Luiz Oliveira de Araújo Lima, Vera Targino Moreira Barbosa-Filho, José Maria Marta Maria de França Fonteles Silvânia Maria Mendes de Vasconcelos Glauce Socorro de Barros Viana Francisca Cléa Florenço de Sousa |
| description | This work presents behavioral effects of (O-methyl)-N-2,6-dihydroxybenzoyl-tyramine (riparin III) isolated from the unripe fruit of Aniba riparia (NEES) MEZ (Lauraceae) in animal models of open field, rota rod, elevated plus maze and hole board tests in mice. Riparin III (ripIII) was administered orally, in male mice, at single doses of 25 and 50 mg/kg. The results showed that ripIII, at both doses, had no effects on the spontaneous motor activity in the rota rod test nor in the number of squares crossed in the open field test. However, riparin III decreased the number of grooming and rearing. In the plus maze test, ripIII, at both doses increased the following parameters: percentage of entries in the open arms (PEOA), time of permanence in the open arms (TPOA) and percentage of time of permanence in the open arms (PTOA) and at the dose of 50 mg/kg, increased the number of entries in the open arms (NEOA). Similarly, ripIII, at both doses, showed an increase in the number of head dips into the holes of the hole board test. These results show that riparin III presents anxiolytic effects in the plus maze and hole board tests which are not influenced by the locomotor activity in the open field test. |
| doi_str_mv | 10.1248/bpb.29.451 |
| format | Article |
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Riparin III (ripIII) was administered orally, in male mice, at single doses of 25 and 50 mg/kg. The results showed that ripIII, at both doses, had no effects on the spontaneous motor activity in the rota rod test nor in the number of squares crossed in the open field test. However, riparin III decreased the number of grooming and rearing. In the plus maze test, ripIII, at both doses increased the following parameters: percentage of entries in the open arms (PEOA), time of permanence in the open arms (TPOA) and percentage of time of permanence in the open arms (PTOA) and at the dose of 50 mg/kg, increased the number of entries in the open arms (NEOA). Similarly, ripIII, at both doses, showed an increase in the number of head dips into the holes of the hole board test. These results show that riparin III presents anxiolytic effects in the plus maze and hole board tests which are not influenced by the locomotor activity in the open field test.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.29.451</identifier><identifier>PMID: 16508144</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Aniba riparia ; Animals ; Anti-Anxiety Agents - pharmacology ; Antidepressive Agents - pharmacology ; anxiolytic effect ; Benzamides - pharmacology ; Diazepam - pharmacology ; Exploratory Behavior - drug effects ; Injections, Intraperitoneal ; Lauraceae - chemistry ; Male ; Mice ; Motor Activity - drug effects ; Postural Balance - drug effects ; riparin III ; Tyramine - analogs & derivatives ; Tyramine - pharmacology</subject><ispartof>Biological and Pharmaceutical Bulletin, 2006, Vol.29(3), pp.451-454</ispartof><rights>2006 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c684t-8841a4f84152f6166dac49d24a708dd8604db2783831aef928524e8d32ac59243</citedby><cites>FETCH-LOGICAL-c684t-8841a4f84152f6166dac49d24a708dd8604db2783831aef928524e8d32ac59243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16508144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carla Thiciane Vasconcelos de Melo</creatorcontrib><creatorcontrib>Monteiro, Andreisa Paiva</creatorcontrib><creatorcontrib>Leite, Caroline Porto</creatorcontrib><creatorcontrib>Fernando Luiz Oliveira de Araújo</creatorcontrib><creatorcontrib>Lima, Vera Targino Moreira</creatorcontrib><creatorcontrib>Barbosa-Filho, José Maria</creatorcontrib><creatorcontrib>Marta Maria de França Fonteles</creatorcontrib><creatorcontrib>Silvânia Maria Mendes de Vasconcelos</creatorcontrib><creatorcontrib>Glauce Socorro de Barros Viana</creatorcontrib><creatorcontrib>Francisca Cléa Florenço de Sousa</creatorcontrib><creatorcontrib>Faculty of Medicine</creatorcontrib><creatorcontrib>Federal University of Paraiba</creatorcontrib><creatorcontrib>aDepartment of Physiology and Pharmacology</creatorcontrib><creatorcontrib>bLaboratory of Pharmaceutics Technology</creatorcontrib><creatorcontrib>Federal University of Ceara</creatorcontrib><title>Anxiolytic-Like Effects of (O-Methyl)-N-2,6-dihydroxybenzoyl-tyramine (Riparin III) from Aniba riparia (NEES) MEZ (Lauraceae) in Mice</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>This work presents behavioral effects of (O-methyl)-N-2,6-dihydroxybenzoyl-tyramine (riparin III) isolated from the unripe fruit of Aniba riparia (NEES) MEZ (Lauraceae) in animal models of open field, rota rod, elevated plus maze and hole board tests in mice. Riparin III (ripIII) was administered orally, in male mice, at single doses of 25 and 50 mg/kg. The results showed that ripIII, at both doses, had no effects on the spontaneous motor activity in the rota rod test nor in the number of squares crossed in the open field test. However, riparin III decreased the number of grooming and rearing. In the plus maze test, ripIII, at both doses increased the following parameters: percentage of entries in the open arms (PEOA), time of permanence in the open arms (TPOA) and percentage of time of permanence in the open arms (PTOA) and at the dose of 50 mg/kg, increased the number of entries in the open arms (NEOA). Similarly, ripIII, at both doses, showed an increase in the number of head dips into the holes of the hole board test. These results show that riparin III presents anxiolytic effects in the plus maze and hole board tests which are not influenced by the locomotor activity in the open field test.</description><subject>Aniba riparia</subject><subject>Animals</subject><subject>Anti-Anxiety Agents - pharmacology</subject><subject>Antidepressive Agents - pharmacology</subject><subject>anxiolytic effect</subject><subject>Benzamides - pharmacology</subject><subject>Diazepam - pharmacology</subject><subject>Exploratory Behavior - drug effects</subject><subject>Injections, Intraperitoneal</subject><subject>Lauraceae - chemistry</subject><subject>Male</subject><subject>Mice</subject><subject>Motor Activity - drug effects</subject><subject>Postural Balance - drug effects</subject><subject>riparin III</subject><subject>Tyramine - analogs & derivatives</subject><subject>Tyramine - pharmacology</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV2LEzEUhgdR3Lp64w-QgLC0Ymq-J3MlZelqod0FP268CZlMxqZOJzWZgR3v939v6nRd8OYEcp7zvofzZtlrjOaYMPmhPJRzUswZx0-yCaYsh5xg_jSboAJLKDCXZ9mLGHcIoRwR-jw7w4IjiRmbZHeL9tb5ZuicgWv3y4JlXVvTReBrML2BG9tth2YGryF5L2DltkMV_O1Q2vaPHxrYDUHvXWvB9Is76OBasFqtZqAOfg8WrSs1CH__NZheL5dfZ2Cz_AGma90Hbay2M5AmNs7Yl9mzWjfRvjq959n3q-W3y89wffNpdblYQyMk66CUDGtWp8pJLbAQlTasqAjTOZJVJQViVUlySSXF2tYFkZwwKytKtOEFYfQ8uxh1D8H_7m3s1N5FY5tGt9b3UYk8R5RzmcC3_4E734c27abS2QrKJSM4Ue9GygQfY7C1OgS312FQGKljNCpFo0ihUjQJfnOS7Mu9rR7RUxYJuBqB1HVGN75t0mkfjU3MyxSVVwQhoRAiBaIKJSeU5I-FcUILIpLQx1FoFzv90_5z0iGl3NiHpehYjsMPHbPVQdmW3gPUX7K0</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>Carla Thiciane Vasconcelos de Melo</creator><creator>Monteiro, Andreisa Paiva</creator><creator>Leite, Caroline Porto</creator><creator>Fernando Luiz Oliveira de Araújo</creator><creator>Lima, Vera Targino Moreira</creator><creator>Barbosa-Filho, José Maria</creator><creator>Marta Maria de França Fonteles</creator><creator>Silvânia Maria Mendes de Vasconcelos</creator><creator>Glauce Socorro de Barros Viana</creator><creator>Francisca Cléa Florenço de Sousa</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20060301</creationdate><title>Anxiolytic-Like Effects of (O-Methyl)-N-2,6-dihydroxybenzoyl-tyramine (Riparin III) from Aniba riparia (NEES) MEZ (Lauraceae) in Mice</title><author>Carla Thiciane Vasconcelos de Melo ; Monteiro, Andreisa Paiva ; Leite, Caroline Porto ; Fernando Luiz Oliveira de Araújo ; Lima, Vera Targino Moreira ; Barbosa-Filho, José Maria ; Marta Maria de França Fonteles ; Silvânia Maria Mendes de Vasconcelos ; Glauce Socorro de Barros Viana ; Francisca Cléa Florenço de Sousa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c684t-8841a4f84152f6166dac49d24a708dd8604db2783831aef928524e8d32ac59243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aniba riparia</topic><topic>Animals</topic><topic>Anti-Anxiety Agents - pharmacology</topic><topic>Antidepressive Agents - pharmacology</topic><topic>anxiolytic effect</topic><topic>Benzamides - pharmacology</topic><topic>Diazepam - pharmacology</topic><topic>Exploratory Behavior - drug effects</topic><topic>Injections, Intraperitoneal</topic><topic>Lauraceae - chemistry</topic><topic>Male</topic><topic>Mice</topic><topic>Motor Activity - drug effects</topic><topic>Postural Balance - drug effects</topic><topic>riparin III</topic><topic>Tyramine - analogs & derivatives</topic><topic>Tyramine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carla Thiciane Vasconcelos de Melo</creatorcontrib><creatorcontrib>Monteiro, Andreisa Paiva</creatorcontrib><creatorcontrib>Leite, Caroline Porto</creatorcontrib><creatorcontrib>Fernando Luiz Oliveira de Araújo</creatorcontrib><creatorcontrib>Lima, Vera Targino Moreira</creatorcontrib><creatorcontrib>Barbosa-Filho, José Maria</creatorcontrib><creatorcontrib>Marta Maria de França Fonteles</creatorcontrib><creatorcontrib>Silvânia Maria Mendes de Vasconcelos</creatorcontrib><creatorcontrib>Glauce Socorro de Barros Viana</creatorcontrib><creatorcontrib>Francisca Cléa Florenço de Sousa</creatorcontrib><creatorcontrib>Faculty of Medicine</creatorcontrib><creatorcontrib>Federal University of Paraiba</creatorcontrib><creatorcontrib>aDepartment of Physiology and Pharmacology</creatorcontrib><creatorcontrib>bLaboratory of Pharmaceutics Technology</creatorcontrib><creatorcontrib>Federal University of Ceara</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carla Thiciane Vasconcelos de Melo</au><au>Monteiro, Andreisa Paiva</au><au>Leite, Caroline Porto</au><au>Fernando Luiz Oliveira de Araújo</au><au>Lima, Vera Targino Moreira</au><au>Barbosa-Filho, José Maria</au><au>Marta Maria de França Fonteles</au><au>Silvânia Maria Mendes de Vasconcelos</au><au>Glauce Socorro de Barros Viana</au><au>Francisca Cléa Florenço de Sousa</au><aucorp>Faculty of Medicine</aucorp><aucorp>Federal University of Paraiba</aucorp><aucorp>aDepartment of Physiology and Pharmacology</aucorp><aucorp>bLaboratory of Pharmaceutics Technology</aucorp><aucorp>Federal University of Ceara</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anxiolytic-Like Effects of (O-Methyl)-N-2,6-dihydroxybenzoyl-tyramine (Riparin III) from Aniba riparia (NEES) MEZ (Lauraceae) in Mice</atitle><jtitle>Biological & Pharmaceutical Bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>29</volume><issue>3</issue><spage>451</spage><epage>454</epage><pages>451-454</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>This work presents behavioral effects of (O-methyl)-N-2,6-dihydroxybenzoyl-tyramine (riparin III) isolated from the unripe fruit of Aniba riparia (NEES) MEZ (Lauraceae) in animal models of open field, rota rod, elevated plus maze and hole board tests in mice. Riparin III (ripIII) was administered orally, in male mice, at single doses of 25 and 50 mg/kg. The results showed that ripIII, at both doses, had no effects on the spontaneous motor activity in the rota rod test nor in the number of squares crossed in the open field test. However, riparin III decreased the number of grooming and rearing. In the plus maze test, ripIII, at both doses increased the following parameters: percentage of entries in the open arms (PEOA), time of permanence in the open arms (TPOA) and percentage of time of permanence in the open arms (PTOA) and at the dose of 50 mg/kg, increased the number of entries in the open arms (NEOA). Similarly, ripIII, at both doses, showed an increase in the number of head dips into the holes of the hole board test. These results show that riparin III presents anxiolytic effects in the plus maze and hole board tests which are not influenced by the locomotor activity in the open field test.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>16508144</pmid><doi>10.1248/bpb.29.451</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Biological and Pharmaceutical Bulletin, 2006, Vol.29(3), pp.451-454 |
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| subjects | Aniba riparia Animals Anti-Anxiety Agents - pharmacology Antidepressive Agents - pharmacology anxiolytic effect Benzamides - pharmacology Diazepam - pharmacology Exploratory Behavior - drug effects Injections, Intraperitoneal Lauraceae - chemistry Male Mice Motor Activity - drug effects Postural Balance - drug effects riparin III Tyramine - analogs & derivatives Tyramine - pharmacology |
| title | Anxiolytic-Like Effects of (O-Methyl)-N-2,6-dihydroxybenzoyl-tyramine (Riparin III) from Aniba riparia (NEES) MEZ (Lauraceae) in Mice |
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