High prevalence of genital human papillomavirus type 52 and 58 infection in women attending gynecologic practitioners in South Taiwan
We attempted to determine the prevalence of genital human papillomavirus (HPV) infection in women attending gynecologic practitioners in South Taiwan. The population included 4383 women aged 16–78 seeking HPV testing at primary gynecologic practitioners regardless of their cervical cytology results....
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| Veröffentlicht in: | Gynecologic oncology 2006-04, Vol.101 (1), p.40-45 |
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| creator | Lin, Hao Ma, Yen-Ying Moh, Jau-Sung Ou, Yu-Che Shen, Shu-Yun ChangChien, Chan-Chao |
| description | We attempted to determine the prevalence of genital human papillomavirus (HPV) infection in women attending gynecologic practitioners in South Taiwan.
The population included 4383 women aged 16–78 seeking HPV testing at primary gynecologic practitioners regardless of their cervical cytology results. HPV DNA was identified from cervical swabs using semi-nested polymerase chain reaction with MY11, MY09/HMB01, and MY11/bioGP6+ primers. Genotyping for high-risk HPV (HR-HPV) was done separately by a HR-HPV chip, which contained 13 type-specific oligonucleotides on a nylon membrane.
The overall HPV prevalence was 19.3% (849/4383), 11.1% (488/4383) were confirmed as HR-HPV positive. Among the women with HR-HPV infection, HPV-16 was the most prevalent type (22.1%; 108/488), followed by HPV-52 (21.3%; 104/488), and HPV-58 (19.9%; 97/488). Multiple infections were detected in 73 women (15.0%; 73/488). For women with age 30 or younger, the overall HPV and HR-HPV prevalence were 32.0% and 20.7%, respectively, which were significantly higher than those of women age older than 30 (17.2% and 9.5%, P |
| doi_str_mv | 10.1016/j.ygyno.2005.09.028 |
| format | Article |
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The population included 4383 women aged 16–78 seeking HPV testing at primary gynecologic practitioners regardless of their cervical cytology results. HPV DNA was identified from cervical swabs using semi-nested polymerase chain reaction with MY11, MY09/HMB01, and MY11/bioGP6+ primers. Genotyping for high-risk HPV (HR-HPV) was done separately by a HR-HPV chip, which contained 13 type-specific oligonucleotides on a nylon membrane.
The overall HPV prevalence was 19.3% (849/4383), 11.1% (488/4383) were confirmed as HR-HPV positive. Among the women with HR-HPV infection, HPV-16 was the most prevalent type (22.1%; 108/488), followed by HPV-52 (21.3%; 104/488), and HPV-58 (19.9%; 97/488). Multiple infections were detected in 73 women (15.0%; 73/488). For women with age 30 or younger, the overall HPV and HR-HPV prevalence were 32.0% and 20.7%, respectively, which were significantly higher than those of women age older than 30 (17.2% and 9.5%, P < 0.001). More multiple infections (22.1% vs. 12.4%) were also found in women with age 30 or younger (P = 0.021). However, the relative contribution of types to the overall HR-HPV positive among different age groups remains the same.
Our results showed an HPV prevalence that is similar compared with worldwide levels. HPV prevalence and multiple infections rate were decreasing across the age groups. Unlike most previous studies, the relative high prevalence of HPV 52 and 58 among South Taiwan women has important implications in vaccine prophylaxis.</description><identifier>ISSN: 0090-8258</identifier><identifier>EISSN: 1095-6859</identifier><identifier>DOI: 10.1016/j.ygyno.2005.09.028</identifier><identifier>PMID: 16256180</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Female ; Genital Diseases, Female - epidemiology ; Genital Diseases, Female - virology ; Human papillomavirus ; Humans ; Middle Aged ; Papillomaviridae - classification ; Papillomavirus Infections - epidemiology ; Papillomavirus Infections - virology ; Prevalence ; Taiwan - epidemiology</subject><ispartof>Gynecologic oncology, 2006-04, Vol.101 (1), p.40-45</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-2f4ee2bba16cad732731840c2e75f35b114913497e59f10d05c37d835a54d43b3</citedby><cites>FETCH-LOGICAL-c423t-2f4ee2bba16cad732731840c2e75f35b114913497e59f10d05c37d835a54d43b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ygyno.2005.09.028$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16256180$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Hao</creatorcontrib><creatorcontrib>Ma, Yen-Ying</creatorcontrib><creatorcontrib>Moh, Jau-Sung</creatorcontrib><creatorcontrib>Ou, Yu-Che</creatorcontrib><creatorcontrib>Shen, Shu-Yun</creatorcontrib><creatorcontrib>ChangChien, Chan-Chao</creatorcontrib><title>High prevalence of genital human papillomavirus type 52 and 58 infection in women attending gynecologic practitioners in South Taiwan</title><title>Gynecologic oncology</title><addtitle>Gynecol Oncol</addtitle><description>We attempted to determine the prevalence of genital human papillomavirus (HPV) infection in women attending gynecologic practitioners in South Taiwan.
The population included 4383 women aged 16–78 seeking HPV testing at primary gynecologic practitioners regardless of their cervical cytology results. HPV DNA was identified from cervical swabs using semi-nested polymerase chain reaction with MY11, MY09/HMB01, and MY11/bioGP6+ primers. Genotyping for high-risk HPV (HR-HPV) was done separately by a HR-HPV chip, which contained 13 type-specific oligonucleotides on a nylon membrane.
The overall HPV prevalence was 19.3% (849/4383), 11.1% (488/4383) were confirmed as HR-HPV positive. Among the women with HR-HPV infection, HPV-16 was the most prevalent type (22.1%; 108/488), followed by HPV-52 (21.3%; 104/488), and HPV-58 (19.9%; 97/488). Multiple infections were detected in 73 women (15.0%; 73/488). For women with age 30 or younger, the overall HPV and HR-HPV prevalence were 32.0% and 20.7%, respectively, which were significantly higher than those of women age older than 30 (17.2% and 9.5%, P < 0.001). More multiple infections (22.1% vs. 12.4%) were also found in women with age 30 or younger (P = 0.021). However, the relative contribution of types to the overall HR-HPV positive among different age groups remains the same.
Our results showed an HPV prevalence that is similar compared with worldwide levels. HPV prevalence and multiple infections rate were decreasing across the age groups. Unlike most previous studies, the relative high prevalence of HPV 52 and 58 among South Taiwan women has important implications in vaccine prophylaxis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Female</subject><subject>Genital Diseases, Female - epidemiology</subject><subject>Genital Diseases, Female - virology</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Papillomaviridae - classification</subject><subject>Papillomavirus Infections - epidemiology</subject><subject>Papillomavirus Infections - virology</subject><subject>Prevalence</subject><subject>Taiwan - epidemiology</subject><issn>0090-8258</issn><issn>1095-6859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtu1DAUhi0EokPbJ0BCXrFLOLbjXBYsUAUUqVIXLWvLcU4yHiV2sJOp5gF4bxxmJHaszll8_7l8hLxnkDNg5adDfhpOzuccQObQ5MDrV2THoJFZWcvmNdkBNJDVXNZX5F2MBwAQwPhbcsVKLktWw478vrfDns4Bj3pEZ5D6ng7o7KJHul8n7eisZzuOftJHG9ZIl9OMVHKqXUdlTa3r0SzWu9TRFz-ho3pZ0HXWDTSdh8aPfrAmrdCJ20gMcYOf_Lrs6bO2L9rdkDe9HiPeXuo1-fnt6_Pdffbw-P3H3ZeHzBRcLBnvC0TetpqVRneV4JVgdQGGYyV7IVvGioaJoqlQNj2DDqQRVVcLqWXRFaIV1-Tjee4c_K8V46ImGw2Oo3bo16jKqgIOokqgOIMm-BgD9moOdtLhpBiozb46qL_21WZfQaOS_ZT6cBm_thN2_zIX3Qn4fAYwPXm0GFQ0dtPe2ZA0qs7b_y74Az8emOU</recordid><startdate>200604</startdate><enddate>200604</enddate><creator>Lin, Hao</creator><creator>Ma, Yen-Ying</creator><creator>Moh, Jau-Sung</creator><creator>Ou, Yu-Che</creator><creator>Shen, Shu-Yun</creator><creator>ChangChien, Chan-Chao</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200604</creationdate><title>High prevalence of genital human papillomavirus type 52 and 58 infection in women attending gynecologic practitioners in South Taiwan</title><author>Lin, Hao ; Ma, Yen-Ying ; Moh, Jau-Sung ; Ou, Yu-Che ; Shen, Shu-Yun ; ChangChien, Chan-Chao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-2f4ee2bba16cad732731840c2e75f35b114913497e59f10d05c37d835a54d43b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Female</topic><topic>Genital Diseases, Female - epidemiology</topic><topic>Genital Diseases, Female - virology</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Papillomaviridae - classification</topic><topic>Papillomavirus Infections - epidemiology</topic><topic>Papillomavirus Infections - virology</topic><topic>Prevalence</topic><topic>Taiwan - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Hao</creatorcontrib><creatorcontrib>Ma, Yen-Ying</creatorcontrib><creatorcontrib>Moh, Jau-Sung</creatorcontrib><creatorcontrib>Ou, Yu-Che</creatorcontrib><creatorcontrib>Shen, Shu-Yun</creatorcontrib><creatorcontrib>ChangChien, Chan-Chao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Hao</au><au>Ma, Yen-Ying</au><au>Moh, Jau-Sung</au><au>Ou, Yu-Che</au><au>Shen, Shu-Yun</au><au>ChangChien, Chan-Chao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High prevalence of genital human papillomavirus type 52 and 58 infection in women attending gynecologic practitioners in South Taiwan</atitle><jtitle>Gynecologic oncology</jtitle><addtitle>Gynecol Oncol</addtitle><date>2006-04</date><risdate>2006</risdate><volume>101</volume><issue>1</issue><spage>40</spage><epage>45</epage><pages>40-45</pages><issn>0090-8258</issn><eissn>1095-6859</eissn><abstract>We attempted to determine the prevalence of genital human papillomavirus (HPV) infection in women attending gynecologic practitioners in South Taiwan.
The population included 4383 women aged 16–78 seeking HPV testing at primary gynecologic practitioners regardless of their cervical cytology results. HPV DNA was identified from cervical swabs using semi-nested polymerase chain reaction with MY11, MY09/HMB01, and MY11/bioGP6+ primers. Genotyping for high-risk HPV (HR-HPV) was done separately by a HR-HPV chip, which contained 13 type-specific oligonucleotides on a nylon membrane.
The overall HPV prevalence was 19.3% (849/4383), 11.1% (488/4383) were confirmed as HR-HPV positive. Among the women with HR-HPV infection, HPV-16 was the most prevalent type (22.1%; 108/488), followed by HPV-52 (21.3%; 104/488), and HPV-58 (19.9%; 97/488). Multiple infections were detected in 73 women (15.0%; 73/488). For women with age 30 or younger, the overall HPV and HR-HPV prevalence were 32.0% and 20.7%, respectively, which were significantly higher than those of women age older than 30 (17.2% and 9.5%, P < 0.001). More multiple infections (22.1% vs. 12.4%) were also found in women with age 30 or younger (P = 0.021). However, the relative contribution of types to the overall HR-HPV positive among different age groups remains the same.
Our results showed an HPV prevalence that is similar compared with worldwide levels. HPV prevalence and multiple infections rate were decreasing across the age groups. Unlike most previous studies, the relative high prevalence of HPV 52 and 58 among South Taiwan women has important implications in vaccine prophylaxis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16256180</pmid><doi>10.1016/j.ygyno.2005.09.028</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adolescent Adult Aged Female Genital Diseases, Female - epidemiology Genital Diseases, Female - virology Human papillomavirus Humans Middle Aged Papillomaviridae - classification Papillomavirus Infections - epidemiology Papillomavirus Infections - virology Prevalence Taiwan - epidemiology |
| title | High prevalence of genital human papillomavirus type 52 and 58 infection in women attending gynecologic practitioners in South Taiwan |
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