Novel Symmetric and Asymmetric DNA Scission Determinants for Streptococcus pneumoniae Topoisomerase IV and Gyrase Are Clustered at the DNA Breakage Site

Topoisomerase (topo) IV and gyrase are bacterial type IIA DNA topoisomerases essential for DNA replication and chromosome segregation that act via a transient double-stranded DNA break involving a covalent enzyme-DNA “cleavage complex.” Despite their mechanistic importance, the DNA breakage determin...

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Veröffentlicht in:	The Journal of biological chemistry 2005-04, Vol.280 (14), p.14252-14263
Hauptverfasser:	Leo, Elisabetta, Gould, Katherine A., Pan, Xiao-Su, Capranico, Giovanni, Sanderson, Mark R., Palumbo, Manlio, Fisher, L. Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacterial Proteins - genetics Bacterial Proteins - metabolism Base Sequence DNA Gyrase - genetics DNA Gyrase - metabolism DNA Replication DNA Topoisomerase IV - genetics DNA Topoisomerase IV - metabolism DNA, Superhelical - chemistry DNA, Superhelical - genetics DNA, Superhelical - metabolism Drug Resistance, Bacterial - genetics Fluoroquinolones - chemistry Fluoroquinolones - metabolism Fluoroquinolones - pharmacology Microbial Sensitivity Tests Molecular Sequence Data Nucleic Acid Conformation Sequence Alignment Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - enzymology Streptococcus pneumoniae - genetics
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