CD40 ligand and risk of ischemic stroke or coronary events in patients with chronic coronary heart disease
CD40 ligand (CD40L) is a trimeric, transmembrane protein of the tumor necrosis factor family and together with its receptor CD40 is an important contributor to the inflammatory processes that lead to atherosclerosis, plaque destabilization, and thrombosis. In order to assess the association between...
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| Veröffentlicht in: | International journal of cardiology 2006-03, Vol.107 (3), p.322-326 |
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| container_title | International journal of cardiology |
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| creator | Tanne, David Haim, Moti Goldbourt, Uri Boyko, Valentina Reshef, Tamar Adler, Yehuda Benderly, Michal Mekori, Yoseph A. Behar, Solomon |
| description | CD40 ligand (CD40L) is a trimeric, transmembrane protein of the tumor necrosis factor family and together with its receptor CD40 is an important contributor to the inflammatory processes that lead to atherosclerosis, plaque destabilization, and thrombosis.
In order to assess the association between serum concentrations of CD40 ligand (CD40L) and risk of future ischemic stroke and coronary events among patients with chronic CHD, we obtained baseline serum samples from patients (
n
=
3090) with chronic CHD enrolled in a secondary prevention trial. With a prospective nested case-control design, we measured baseline CD40L concentration in sera of patients who subsequently developed myocardial infarction, sudden cardiac death or ischemic stroke during follow-up (cases,
n
=
233) and in 233 age- and gender-matched pairs without any subsequent cardiovascular events.
Relative odds for recurrent cardiovascular events per one natural log unit difference of CD40L were 0.97 (95%CI, 0.82–1.16). No increase in relative odds for recurrent cardiovascular events was observed per increasing quartiles of CD40L concentrations. In analysis for individual end-points, different trends of risks were observed beyond the 95 percentile for ischemic stroke (OR 2.22; 95%CI, 0.46–12.5) and for recurrent coronary events (OR 0.35; 95%CI, 0.07–1.37), but falling short of statistical significance.
High serum concentrations of CD40L were not associated with increased risk of ischemic stroke or coronary events in patients with chronic coronary heart disease. |
| doi_str_mv | 10.1016/j.ijcard.2005.03.051 |
| format | Article |
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In order to assess the association between serum concentrations of CD40 ligand (CD40L) and risk of future ischemic stroke and coronary events among patients with chronic CHD, we obtained baseline serum samples from patients (
n
=
3090) with chronic CHD enrolled in a secondary prevention trial. With a prospective nested case-control design, we measured baseline CD40L concentration in sera of patients who subsequently developed myocardial infarction, sudden cardiac death or ischemic stroke during follow-up (cases,
n
=
233) and in 233 age- and gender-matched pairs without any subsequent cardiovascular events.
Relative odds for recurrent cardiovascular events per one natural log unit difference of CD40L were 0.97 (95%CI, 0.82–1.16). No increase in relative odds for recurrent cardiovascular events was observed per increasing quartiles of CD40L concentrations. In analysis for individual end-points, different trends of risks were observed beyond the 95 percentile for ischemic stroke (OR 2.22; 95%CI, 0.46–12.5) and for recurrent coronary events (OR 0.35; 95%CI, 0.07–1.37), but falling short of statistical significance.
High serum concentrations of CD40L were not associated with increased risk of ischemic stroke or coronary events in patients with chronic coronary heart disease.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2005.03.051</identifier><identifier>PMID: 16503253</identifier><identifier>CODEN: IJCDD5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Biological and medical sciences ; Biomarkers - blood ; Cardiology. Vascular system ; Case-Control Studies ; CD40 ligand ; CD40 Ligand - blood ; Chronic Disease ; Coronary Disease - blood ; Coronary heart disease ; Death, Sudden, Cardiac - epidemiology ; Death, Sudden, Cardiac - prevention & control ; Female ; Heart ; Humans ; Ischemic stroke ; Israel - epidemiology ; Male ; Matched-Pair Analysis ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Myocardial Infarction - blood ; Myocardial Infarction - epidemiology ; Myocardial Infarction - prevention & control ; Neurology ; Prospective Studies ; Recurrence ; Risk ; Stroke - blood ; Stroke - epidemiology ; Stroke - prevention & control ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>International journal of cardiology, 2006-03, Vol.107 (3), p.322-326</ispartof><rights>2005 Elsevier Ireland Ltd</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-78a50e24a57666a749935e66c70362261e484bbeab8561588cc89cdd7f76746f3</citedby><cites>FETCH-LOGICAL-c390t-78a50e24a57666a749935e66c70362261e484bbeab8561588cc89cdd7f76746f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S016752730500598X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17568058$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16503253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanne, David</creatorcontrib><creatorcontrib>Haim, Moti</creatorcontrib><creatorcontrib>Goldbourt, Uri</creatorcontrib><creatorcontrib>Boyko, Valentina</creatorcontrib><creatorcontrib>Reshef, Tamar</creatorcontrib><creatorcontrib>Adler, Yehuda</creatorcontrib><creatorcontrib>Benderly, Michal</creatorcontrib><creatorcontrib>Mekori, Yoseph A.</creatorcontrib><creatorcontrib>Behar, Solomon</creatorcontrib><title>CD40 ligand and risk of ischemic stroke or coronary events in patients with chronic coronary heart disease</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>CD40 ligand (CD40L) is a trimeric, transmembrane protein of the tumor necrosis factor family and together with its receptor CD40 is an important contributor to the inflammatory processes that lead to atherosclerosis, plaque destabilization, and thrombosis.
In order to assess the association between serum concentrations of CD40 ligand (CD40L) and risk of future ischemic stroke and coronary events among patients with chronic CHD, we obtained baseline serum samples from patients (
n
=
3090) with chronic CHD enrolled in a secondary prevention trial. With a prospective nested case-control design, we measured baseline CD40L concentration in sera of patients who subsequently developed myocardial infarction, sudden cardiac death or ischemic stroke during follow-up (cases,
n
=
233) and in 233 age- and gender-matched pairs without any subsequent cardiovascular events.
Relative odds for recurrent cardiovascular events per one natural log unit difference of CD40L were 0.97 (95%CI, 0.82–1.16). No increase in relative odds for recurrent cardiovascular events was observed per increasing quartiles of CD40L concentrations. In analysis for individual end-points, different trends of risks were observed beyond the 95 percentile for ischemic stroke (OR 2.22; 95%CI, 0.46–12.5) and for recurrent coronary events (OR 0.35; 95%CI, 0.07–1.37), but falling short of statistical significance.
High serum concentrations of CD40L were not associated with increased risk of ischemic stroke or coronary events in patients with chronic coronary heart disease.</description><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>CD40 ligand</subject><subject>CD40 Ligand - blood</subject><subject>Chronic Disease</subject><subject>Coronary Disease - blood</subject><subject>Coronary heart disease</subject><subject>Death, Sudden, Cardiac - epidemiology</subject><subject>Death, Sudden, Cardiac - prevention & control</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Ischemic stroke</subject><subject>Israel - epidemiology</subject><subject>Male</subject><subject>Matched-Pair Analysis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Myocardial Infarction - prevention & control</subject><subject>Neurology</subject><subject>Prospective Studies</subject><subject>Recurrence</subject><subject>Risk</subject><subject>Stroke - blood</subject><subject>Stroke - epidemiology</subject><subject>Stroke - prevention & control</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PGzEURa0KVALtP6gqb-huhufxZzaVqlAoEhIbWFuO503jYTJO7Ukq_j0OicquC8tenHt1fQj5wqBmwNRVX4feu9TWDYCsgdcg2QcyY0aLimkpTsisYLqSjeZn5DznHgDEfG4-kjOmJPBG8hnpF9cC6BB-u7Gl-5NCfqaxoyH7Fa6Dp3lK8RlpTNTHFEeXXijucJwyDSPduCm8vf-GaUX9qgAl8g9coUsTbUNGl_ETOe3ckPHz8b4gTzc_Hxe_qvuH27vFj_vK8zlMlTZOAjbCSa2UcrpM5hKV8hq4ahrFUBixXKJbGqmYNMZ7M_dtqzuttFAdvyDfDr2bFP9sMU92XT6Dw-BGjNtsldbASlcBxQH0KeacsLObFNZlt2Vg945tbw-O7d6xBW6L4xL7euzfLtfYvoeOUgtweQRc9m7okht9yO-clsqANIX7fuCw2NgFTDb7YtNjGxL6ybYx_H_JKzvWm7c</recordid><startdate>20060308</startdate><enddate>20060308</enddate><creator>Tanne, David</creator><creator>Haim, Moti</creator><creator>Goldbourt, Uri</creator><creator>Boyko, Valentina</creator><creator>Reshef, Tamar</creator><creator>Adler, Yehuda</creator><creator>Benderly, Michal</creator><creator>Mekori, Yoseph A.</creator><creator>Behar, Solomon</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060308</creationdate><title>CD40 ligand and risk of ischemic stroke or coronary events in patients with chronic coronary heart disease</title><author>Tanne, David ; Haim, Moti ; Goldbourt, Uri ; Boyko, Valentina ; Reshef, Tamar ; Adler, Yehuda ; Benderly, Michal ; Mekori, Yoseph A. ; Behar, Solomon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-78a50e24a57666a749935e66c70362261e484bbeab8561588cc89cdd7f76746f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>CD40 ligand</topic><topic>CD40 Ligand - blood</topic><topic>Chronic Disease</topic><topic>Coronary Disease - blood</topic><topic>Coronary heart disease</topic><topic>Death, Sudden, Cardiac - epidemiology</topic><topic>Death, Sudden, Cardiac - prevention & control</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Ischemic stroke</topic><topic>Israel - epidemiology</topic><topic>Male</topic><topic>Matched-Pair Analysis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - epidemiology</topic><topic>Myocardial Infarction - prevention & control</topic><topic>Neurology</topic><topic>Prospective Studies</topic><topic>Recurrence</topic><topic>Risk</topic><topic>Stroke - blood</topic><topic>Stroke - epidemiology</topic><topic>Stroke - prevention & control</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanne, David</creatorcontrib><creatorcontrib>Haim, Moti</creatorcontrib><creatorcontrib>Goldbourt, Uri</creatorcontrib><creatorcontrib>Boyko, Valentina</creatorcontrib><creatorcontrib>Reshef, Tamar</creatorcontrib><creatorcontrib>Adler, Yehuda</creatorcontrib><creatorcontrib>Benderly, Michal</creatorcontrib><creatorcontrib>Mekori, Yoseph A.</creatorcontrib><creatorcontrib>Behar, Solomon</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanne, David</au><au>Haim, Moti</au><au>Goldbourt, Uri</au><au>Boyko, Valentina</au><au>Reshef, Tamar</au><au>Adler, Yehuda</au><au>Benderly, Michal</au><au>Mekori, Yoseph A.</au><au>Behar, Solomon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD40 ligand and risk of ischemic stroke or coronary events in patients with chronic coronary heart disease</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2006-03-08</date><risdate>2006</risdate><volume>107</volume><issue>3</issue><spage>322</spage><epage>326</epage><pages>322-326</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><coden>IJCDD5</coden><abstract>CD40 ligand (CD40L) is a trimeric, transmembrane protein of the tumor necrosis factor family and together with its receptor CD40 is an important contributor to the inflammatory processes that lead to atherosclerosis, plaque destabilization, and thrombosis.
In order to assess the association between serum concentrations of CD40 ligand (CD40L) and risk of future ischemic stroke and coronary events among patients with chronic CHD, we obtained baseline serum samples from patients (
n
=
3090) with chronic CHD enrolled in a secondary prevention trial. With a prospective nested case-control design, we measured baseline CD40L concentration in sera of patients who subsequently developed myocardial infarction, sudden cardiac death or ischemic stroke during follow-up (cases,
n
=
233) and in 233 age- and gender-matched pairs without any subsequent cardiovascular events.
Relative odds for recurrent cardiovascular events per one natural log unit difference of CD40L were 0.97 (95%CI, 0.82–1.16). No increase in relative odds for recurrent cardiovascular events was observed per increasing quartiles of CD40L concentrations. In analysis for individual end-points, different trends of risks were observed beyond the 95 percentile for ischemic stroke (OR 2.22; 95%CI, 0.46–12.5) and for recurrent coronary events (OR 0.35; 95%CI, 0.07–1.37), but falling short of statistical significance.
High serum concentrations of CD40L were not associated with increased risk of ischemic stroke or coronary events in patients with chronic coronary heart disease.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>16503253</pmid><doi>10.1016/j.ijcard.2005.03.051</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | International journal of cardiology, 2006-03, Vol.107 (3), p.322-326 |
| issn | 0167-5273 1874-1754 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Biomarkers - blood Cardiology. Vascular system Case-Control Studies CD40 ligand CD40 Ligand - blood Chronic Disease Coronary Disease - blood Coronary heart disease Death, Sudden, Cardiac - epidemiology Death, Sudden, Cardiac - prevention & control Female Heart Humans Ischemic stroke Israel - epidemiology Male Matched-Pair Analysis Medical sciences Middle Aged Multivariate Analysis Myocardial Infarction - blood Myocardial Infarction - epidemiology Myocardial Infarction - prevention & control Neurology Prospective Studies Recurrence Risk Stroke - blood Stroke - epidemiology Stroke - prevention & control Vascular diseases and vascular malformations of the nervous system |
| title | CD40 ligand and risk of ischemic stroke or coronary events in patients with chronic coronary heart disease |
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