Augmentation rhinoplasty using injectable tissue-engineered soft tissue : A pilot study
In a previous animal study, the authors reported that cultured human fibroblasts suspended in Restylane, which is a modified hyaluronic acid, can produce human dermal matrices with extended in vivo stability. This study was undertaken to evaluate the clinical efficacy of this method, particularly fo...
Gespeichert in:
| Veröffentlicht in: | Annals of plastic surgery 2006-03, Vol.56 (3), p.251-255 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 255 |
|---|---|
| container_issue | 3 |
| container_start_page | 251 |
| container_title | Annals of plastic surgery |
| container_volume | 56 |
| creator | HAN, Seung-Kyu SHIN, Seung-Han KANG, Hee-Joon KIM, Woo-Kyung |
| description | In a previous animal study, the authors reported that cultured human fibroblasts suspended in Restylane, which is a modified hyaluronic acid, can produce human dermal matrices with extended in vivo stability. This study was undertaken to evaluate the clinical efficacy of this method, particularly for augmentation rhinoplasty cases. Between January 2002 and June 2003, 11 patients were treated with subcutaneous implants of Restylane mixed with autologous fibroblasts for augmentation rhinoplasty. Of these 11 patients, a long-term follow-up for more than 1 year was possible in 6 patients. Appearance of reconstructed noses, degree and time of resorption, occurrence of complications, and patients' satisfaction were investigated. The injected implants remained in situ without evidence of significant resorption or loss of correction. All patients were satisfied with the achieved long-term results, and no complication occurred. The results obtained indicate that this method is well tolerated and may have a potential to be an effective means of performing augmentation rhinoplasty. |
| doi_str_mv | 10.1097/01.sap.0000198549.64341.17 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67700488</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67700488</sourcerecordid><originalsourceid>FETCH-LOGICAL-c290t-af02824c738585c57aeafc9e33b268347fc3d148455113172be7406a708ce3373</originalsourceid><addsrcrecordid>eNpFkMGK2zAQhsWyZZNN9xWKKGxvdiVLsuTcQmi7hUAvLT0KRRmnCo7seuRD3n6VXUPmMjB8M8P_EfKZs5KzRn9lvEQ3lCwXb4ySTVlLIXnJ9R1ZciXqQmhm7smScWkKzaRYkEfEU8YrI-sHsuC1YkYosSR_N9PxDDG5FPpIx38h9kPnMF3ohCEeaYgn8MntO6ApIE5QQDyGCDDCgWLfpnlM13RDh9D1iWKaDpeP5EPrOoSnua_In-_ffm9fit2vHz-3m13hq4alwrWsMpX0WhhllFfagWt9A0Lsq9oIqVsvDjmFVIpzwXW1By1Z7XI-nyEtVuTL-91h7P9PgMmeA3roOhehn9DWWjMmjcng-h30Y484QmuHMZzdeLGc2atWy7jNWu1Nq33Tavn1y6f5y7Q_w-G2OnvMwPMMOPSua0cXfcAbp_M5ppR4BR9VgZE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67700488</pqid></control><display><type>article</type><title>Augmentation rhinoplasty using injectable tissue-engineered soft tissue : A pilot study</title><source>MEDLINE</source><source>Journals@Ovid Ovid Autoload</source><creator>HAN, Seung-Kyu ; SHIN, Seung-Han ; KANG, Hee-Joon ; KIM, Woo-Kyung</creator><creatorcontrib>HAN, Seung-Kyu ; SHIN, Seung-Han ; KANG, Hee-Joon ; KIM, Woo-Kyung</creatorcontrib><description>In a previous animal study, the authors reported that cultured human fibroblasts suspended in Restylane, which is a modified hyaluronic acid, can produce human dermal matrices with extended in vivo stability. This study was undertaken to evaluate the clinical efficacy of this method, particularly for augmentation rhinoplasty cases. Between January 2002 and June 2003, 11 patients were treated with subcutaneous implants of Restylane mixed with autologous fibroblasts for augmentation rhinoplasty. Of these 11 patients, a long-term follow-up for more than 1 year was possible in 6 patients. Appearance of reconstructed noses, degree and time of resorption, occurrence of complications, and patients' satisfaction were investigated. The injected implants remained in situ without evidence of significant resorption or loss of correction. All patients were satisfied with the achieved long-term results, and no complication occurred. The results obtained indicate that this method is well tolerated and may have a potential to be an effective means of performing augmentation rhinoplasty.</description><identifier>ISSN: 0148-7043</identifier><identifier>EISSN: 1536-3708</identifier><identifier>DOI: 10.1097/01.sap.0000198549.64341.17</identifier><identifier>PMID: 16508353</identifier><identifier>CODEN: APCSD4</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Biological and medical sciences ; Cohort Studies ; Esthetics ; Female ; Fibroblasts - transplantation ; Humans ; Hyaluronic Acid - analogs & derivatives ; Hyaluronic Acid - pharmacology ; Injections, Subcutaneous ; Medical sciences ; Middle Aged ; Patient Satisfaction ; Rhinoplasty - methods ; Risk Assessment ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue Engineering ; Transplantation, Autologous ; Treatment Outcome</subject><ispartof>Annals of plastic surgery, 2006-03, Vol.56 (3), p.251-255</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c290t-af02824c738585c57aeafc9e33b268347fc3d148455113172be7406a708ce3373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17549055$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16508353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HAN, Seung-Kyu</creatorcontrib><creatorcontrib>SHIN, Seung-Han</creatorcontrib><creatorcontrib>KANG, Hee-Joon</creatorcontrib><creatorcontrib>KIM, Woo-Kyung</creatorcontrib><title>Augmentation rhinoplasty using injectable tissue-engineered soft tissue : A pilot study</title><title>Annals of plastic surgery</title><addtitle>Ann Plast Surg</addtitle><description>In a previous animal study, the authors reported that cultured human fibroblasts suspended in Restylane, which is a modified hyaluronic acid, can produce human dermal matrices with extended in vivo stability. This study was undertaken to evaluate the clinical efficacy of this method, particularly for augmentation rhinoplasty cases. Between January 2002 and June 2003, 11 patients were treated with subcutaneous implants of Restylane mixed with autologous fibroblasts for augmentation rhinoplasty. Of these 11 patients, a long-term follow-up for more than 1 year was possible in 6 patients. Appearance of reconstructed noses, degree and time of resorption, occurrence of complications, and patients' satisfaction were investigated. The injected implants remained in situ without evidence of significant resorption or loss of correction. All patients were satisfied with the achieved long-term results, and no complication occurred. The results obtained indicate that this method is well tolerated and may have a potential to be an effective means of performing augmentation rhinoplasty.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Esthetics</subject><subject>Female</subject><subject>Fibroblasts - transplantation</subject><subject>Humans</subject><subject>Hyaluronic Acid - analogs & derivatives</subject><subject>Hyaluronic Acid - pharmacology</subject><subject>Injections, Subcutaneous</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Patient Satisfaction</subject><subject>Rhinoplasty - methods</subject><subject>Risk Assessment</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tissue Engineering</subject><subject>Transplantation, Autologous</subject><subject>Treatment Outcome</subject><issn>0148-7043</issn><issn>1536-3708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMGK2zAQhsWyZZNN9xWKKGxvdiVLsuTcQmi7hUAvLT0KRRmnCo7seuRD3n6VXUPmMjB8M8P_EfKZs5KzRn9lvEQ3lCwXb4ySTVlLIXnJ9R1ZciXqQmhm7smScWkKzaRYkEfEU8YrI-sHsuC1YkYosSR_N9PxDDG5FPpIx38h9kPnMF3ohCEeaYgn8MntO6ApIE5QQDyGCDDCgWLfpnlM13RDh9D1iWKaDpeP5EPrOoSnua_In-_ffm9fit2vHz-3m13hq4alwrWsMpX0WhhllFfagWt9A0Lsq9oIqVsvDjmFVIpzwXW1By1Z7XI-nyEtVuTL-91h7P9PgMmeA3roOhehn9DWWjMmjcng-h30Y484QmuHMZzdeLGc2atWy7jNWu1Nq33Tavn1y6f5y7Q_w-G2OnvMwPMMOPSua0cXfcAbp_M5ppR4BR9VgZE</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>HAN, Seung-Kyu</creator><creator>SHIN, Seung-Han</creator><creator>KANG, Hee-Joon</creator><creator>KIM, Woo-Kyung</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060301</creationdate><title>Augmentation rhinoplasty using injectable tissue-engineered soft tissue : A pilot study</title><author>HAN, Seung-Kyu ; SHIN, Seung-Han ; KANG, Hee-Joon ; KIM, Woo-Kyung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c290t-af02824c738585c57aeafc9e33b268347fc3d148455113172be7406a708ce3373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Esthetics</topic><topic>Female</topic><topic>Fibroblasts - transplantation</topic><topic>Humans</topic><topic>Hyaluronic Acid - analogs & derivatives</topic><topic>Hyaluronic Acid - pharmacology</topic><topic>Injections, Subcutaneous</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Patient Satisfaction</topic><topic>Rhinoplasty - methods</topic><topic>Risk Assessment</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tissue Engineering</topic><topic>Transplantation, Autologous</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HAN, Seung-Kyu</creatorcontrib><creatorcontrib>SHIN, Seung-Han</creatorcontrib><creatorcontrib>KANG, Hee-Joon</creatorcontrib><creatorcontrib>KIM, Woo-Kyung</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of plastic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HAN, Seung-Kyu</au><au>SHIN, Seung-Han</au><au>KANG, Hee-Joon</au><au>KIM, Woo-Kyung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Augmentation rhinoplasty using injectable tissue-engineered soft tissue : A pilot study</atitle><jtitle>Annals of plastic surgery</jtitle><addtitle>Ann Plast Surg</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>56</volume><issue>3</issue><spage>251</spage><epage>255</epage><pages>251-255</pages><issn>0148-7043</issn><eissn>1536-3708</eissn><coden>APCSD4</coden><abstract>In a previous animal study, the authors reported that cultured human fibroblasts suspended in Restylane, which is a modified hyaluronic acid, can produce human dermal matrices with extended in vivo stability. This study was undertaken to evaluate the clinical efficacy of this method, particularly for augmentation rhinoplasty cases. Between January 2002 and June 2003, 11 patients were treated with subcutaneous implants of Restylane mixed with autologous fibroblasts for augmentation rhinoplasty. Of these 11 patients, a long-term follow-up for more than 1 year was possible in 6 patients. Appearance of reconstructed noses, degree and time of resorption, occurrence of complications, and patients' satisfaction were investigated. The injected implants remained in situ without evidence of significant resorption or loss of correction. All patients were satisfied with the achieved long-term results, and no complication occurred. The results obtained indicate that this method is well tolerated and may have a potential to be an effective means of performing augmentation rhinoplasty.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>16508353</pmid><doi>10.1097/01.sap.0000198549.64341.17</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0148-7043 |
| ispartof | Annals of plastic surgery, 2006-03, Vol.56 (3), p.251-255 |
| issn | 0148-7043 1536-3708 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67700488 |
| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Adult Biological and medical sciences Cohort Studies Esthetics Female Fibroblasts - transplantation Humans Hyaluronic Acid - analogs & derivatives Hyaluronic Acid - pharmacology Injections, Subcutaneous Medical sciences Middle Aged Patient Satisfaction Rhinoplasty - methods Risk Assessment Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue Engineering Transplantation, Autologous Treatment Outcome |
| title | Augmentation rhinoplasty using injectable tissue-engineered soft tissue : A pilot study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T12%3A48%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Augmentation%20rhinoplasty%20using%20injectable%20tissue-engineered%20soft%20tissue%20:%20A%20pilot%20study&rft.jtitle=Annals%20of%20plastic%20surgery&rft.au=HAN,%20Seung-Kyu&rft.date=2006-03-01&rft.volume=56&rft.issue=3&rft.spage=251&rft.epage=255&rft.pages=251-255&rft.issn=0148-7043&rft.eissn=1536-3708&rft.coden=APCSD4&rft_id=info:doi/10.1097/01.sap.0000198549.64341.17&rft_dat=%3Cproquest_cross%3E67700488%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67700488&rft_id=info:pmid/16508353&rfr_iscdi=true |