Allelic diversity in the TGFB1 regulatory region : characterization of novel functional single nucleotide polymorphisms

Altered TGF-beta1 expression due to polymorphisms affects a wide variety of normal cellular and disease processes such as T cell activation and proliferation, tumor progression, and asthma. In this study, a comprehensive examination of function and diversity was undertaken for the TGFB1 promoter reg...

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Veröffentlicht in:	Human genetics 2006-03, Vol.119 (1-2), p.61-74
Hauptverfasser:	SHAH, Riddhish, RAHAMAN, Brad, HURLEY, Carolyn Katovich, POSCH, Phillip E
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans - genetics Alleles Alzheimer's disease Asthma Binding Sites Biological and medical sciences Cell Line, Transformed Cell Line, Tumor Classical genetics, quantitative genetics, hybrids Disease DNA-Binding Proteins - metabolism Electrophoretic Mobility Shift Assay Enhancer Elements, Genetic Exons Fundamental and applied biological sciences. Psychology Gene Frequency Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Human Humans Luciferases - genetics Luciferases - metabolism Peptides Phylogeny Polymorphism, Single Nucleotide Promoter Regions, Genetic Protein Binding Proteins Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Regulatory Sequences, Nucleic Acid - genetics Sp1 Transcription Factor - metabolism Sp3 Transcription Factor - metabolism Transcription factors Transfection Transforming Growth Factor beta1 - genetics Transplants & implants
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