Modulatory Effects of Atorvastatin on Endothelial Cell-Derived Chemokines, Cytokines, and Angiogenic Factors

Study Objective. To investigate the immunomodulatory effects of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitors (statins) by determining whether atorvastatin alters the production of specific endothelium‐derived immunoactive proteins and whether its treatment effects depend on its concent...

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Veröffentlicht in:	Pharmacotherapy 2006-03, Vol.26 (3), p.333-340
Hauptverfasser:	Zineh, Issam, Luo, Xiaoping, Welder, Gregory J., DeBella, Amy E., Wessel, Timothy R., Arant, Christopher B., Schofield, Richard S., Chegini, Nasser
Format:	Artikel
Sprache:	eng
Schlagworte:	atherosclerosis Atherosclerosis (general aspects, experimental research) atorvastatin Atorvastatin Calcium Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cells, Cultured Chemokine CCL2 - metabolism Chemokine CXCL5 Chemokines, CXC - metabolism Endothelial Cells - drug effects Endothelial Cells - metabolism endothelium Fibroblast Growth Factors - metabolism Granulocyte Colony-Stimulating Factor - metabolism Heptanoic Acids - pharmacology human umbilical vein endothelial cells Humans HUVEC Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Immunologic Factors - pharmacology inflammation Interleukin-6 - metabolism Interleukin-8 - metabolism Medical sciences Mevalonic Acid - pharmacology Pyrroles - pharmacology statins
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