TNFR2 gene polymorphism in coronary artery disease
BACKGROUND: Recently atherosclerosis and coronary artery disease (CAD) are considered to be inflammatory diseases. The genetic polymorphism in inflammatory markers has been well studied and found to be associated with development of CAD. AIM: To study the association of biallelic polymorphism at pos...
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| Veröffentlicht in: | Indian journal of medical sciences 2005-03, Vol.59 (3), p.104-108 |
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| creator | Sankar VH, Girisha KM, Gilmour A, Singh VP, Sinha N, Tewari S, Ramesh V, Mastana S, Agrawal Suraksha |
| description | BACKGROUND: Recently atherosclerosis and coronary artery disease
(CAD) are considered to be inflammatory diseases. The genetic
polymorphism in inflammatory markers has been well studied and found to
be associated with development of CAD. AIM: To study the association
of biallelic polymorphism at position 196 in exon 6 of tumor necrosis
factor 2 (TNFR2) gene and coronary artery disease. SETTINGS AND
DESIGN: The study design was a prospective case control study
conducted at a tertiary referral center mainly catering to the north
Indian population. MATERIALS AND METHODS: One hundred and fifty
angiographically proven patients with coronary artery disease and one
hundred and fifty age matched controls were genotyped for TNFR2 gene by
polymerase chain reaction followed by analysis of restriction fragment
length polymorphism. STATISTICAL ANALYSIS: Genotype frequencies were
compared in patients and controls by Chi-square test. Binary logistic
regression analysis was used to examine the relationship between
genotypes and disease, incorporating other variables into the model.
RESULTS: The incidence of CAD in those with MM genotype was 65% and in
those with RM genotype was 42%. Genotype frequency shows significant
association of MM genotype with development of CAD (P |
| doi_str_mv | 10.4103/0019-5359.15086 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_67698954</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A131222515</galeid><sourcerecordid>A131222515</sourcerecordid><originalsourceid>FETCH-LOGICAL-b353t-daf5b4e466e5e3112e847e8a45f0273c16ad9a94a8c41f962c4dce2f594647be3</originalsourceid><addsrcrecordid>eNptkctLxDAQxoMouj7O3qR48NY1r0mbo4gvEAXRc0jTqUbaZk12D_vfm3VXBZEEBmZ-X_gyHyHHjE4lo-KcUqZLEKCnDGittsiEaV2XQoHcJpOf6R7ZT-mdUi440F2yx6CmoGo6Ifz54fqJF684YjEL_XIIcfbm01D4sXAhhtHGZWHjHHNpfUKb8JDsdLZPeLSpB-Tl-ur58ra8f7y5u7y4LxsBYl62toNGolQKAQVjHGtZYW0ldJRXwjFlW221tLWTrNOKO9k65B1oqWTVoDggZ-t3ZzF8LDDNzeCTw763I4ZFMqpSutYgM3j6B3wPizhmb4ZpAElZpTNUrqFX26PxYxfm0brVv6Ptw4idz-0LJhjnHBhkfvoPn0-Lg3f_Cs7XAhdDShE7M4t-yOszjJpVWGYVh1nFYb7CyoqTje9FM2D7y2_S-fXQ-ND7EX8IF701380h5UuBZg-f76WdDg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>195540179</pqid></control><display><type>article</type><title>TNFR2 gene polymorphism in coronary artery disease</title><source>MEDLINE</source><source>Bioline International</source><source>EZB Electronic Journals Library</source><creator>Sankar VH, Girisha KM, Gilmour A, Singh VP, Sinha N, Tewari S, Ramesh V, Mastana S, Agrawal Suraksha</creator><creatorcontrib>Sankar VH, Girisha KM, Gilmour A, Singh VP, Sinha N, Tewari S, Ramesh V, Mastana S, Agrawal Suraksha</creatorcontrib><description>BACKGROUND: Recently atherosclerosis and coronary artery disease
(CAD) are considered to be inflammatory diseases. The genetic
polymorphism in inflammatory markers has been well studied and found to
be associated with development of CAD. AIM: To study the association
of biallelic polymorphism at position 196 in exon 6 of tumor necrosis
factor 2 (TNFR2) gene and coronary artery disease. SETTINGS AND
DESIGN: The study design was a prospective case control study
conducted at a tertiary referral center mainly catering to the north
Indian population. MATERIALS AND METHODS: One hundred and fifty
angiographically proven patients with coronary artery disease and one
hundred and fifty age matched controls were genotyped for TNFR2 gene by
polymerase chain reaction followed by analysis of restriction fragment
length polymorphism. STATISTICAL ANALYSIS: Genotype frequencies were
compared in patients and controls by Chi-square test. Binary logistic
regression analysis was used to examine the relationship between
genotypes and disease, incorporating other variables into the model.
RESULTS: The incidence of CAD in those with MM genotype was 65% and in
those with RM genotype was 42%. Genotype frequency shows significant
association of MM genotype with development of CAD (P<0.001; odds
ratio-2.585; 95% confidence interval 1.533-4.359). The association of
TNFR2 genotype with CAD persisted on logistic regression analysis.
CONCLUSION: MM genotype of TNFR2 gene is associated with development
of CAD and RM genotype appears to be protective.</description><identifier>ISSN: 0019-5359</identifier><identifier>EISSN: 1998-3654</identifier><identifier>DOI: 10.4103/0019-5359.15086</identifier><identifier>PMID: 15805680</identifier><language>eng</language><publisher>India: Medknow Publications on behalf of Indian Journal of Medical Sciences Trust</publisher><subject>Adolescent ; Adult ; Alleles ; Atherosclerosis ; Case-Control Studies ; Causes of ; Chi-Square Distribution ; Child ; Cholesterol ; Coronary artery disease, Atherosclerosis, Inflammatory markers, Genetics, Single nucleotide polymorphism, Tumor necrosis factor receptor type II ; Coronary Disease - epidemiology ; Coronary Disease - genetics ; Coronary heart disease ; Female ; Gene expression ; Gene Frequency ; Gene mutations ; Genetic polymorphisms ; Genotype ; Humans ; Incidence ; India - epidemiology ; Inflammation ; Logistic Models ; Male ; Medical research ; Medicine, Experimental ; Middle Aged ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Prospective Studies ; Receptors, Tumor Necrosis Factor - genetics</subject><ispartof>Indian journal of medical sciences, 2005-03, Vol.59 (3), p.104-108</ispartof><rights>Copyright 2005 Indian Journal of Medical Sciences.</rights><rights>COPYRIGHT 2005 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications Mar 2005</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b353t-daf5b4e466e5e3112e847e8a45f0273c16ad9a94a8c41f962c4dce2f594647be3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902,79168</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15805680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sankar VH, Girisha KM, Gilmour A, Singh VP, Sinha N, Tewari S, Ramesh V, Mastana S, Agrawal Suraksha</creatorcontrib><title>TNFR2 gene polymorphism in coronary artery disease</title><title>Indian journal of medical sciences</title><addtitle>Indian J Med Sci</addtitle><description>BACKGROUND: Recently atherosclerosis and coronary artery disease
(CAD) are considered to be inflammatory diseases. The genetic
polymorphism in inflammatory markers has been well studied and found to
be associated with development of CAD. AIM: To study the association
of biallelic polymorphism at position 196 in exon 6 of tumor necrosis
factor 2 (TNFR2) gene and coronary artery disease. SETTINGS AND
DESIGN: The study design was a prospective case control study
conducted at a tertiary referral center mainly catering to the north
Indian population. MATERIALS AND METHODS: One hundred and fifty
angiographically proven patients with coronary artery disease and one
hundred and fifty age matched controls were genotyped for TNFR2 gene by
polymerase chain reaction followed by analysis of restriction fragment
length polymorphism. STATISTICAL ANALYSIS: Genotype frequencies were
compared in patients and controls by Chi-square test. Binary logistic
regression analysis was used to examine the relationship between
genotypes and disease, incorporating other variables into the model.
RESULTS: The incidence of CAD in those with MM genotype was 65% and in
those with RM genotype was 42%. Genotype frequency shows significant
association of MM genotype with development of CAD (P<0.001; odds
ratio-2.585; 95% confidence interval 1.533-4.359). The association of
TNFR2 genotype with CAD persisted on logistic regression analysis.
CONCLUSION: MM genotype of TNFR2 gene is associated with development
of CAD and RM genotype appears to be protective.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Alleles</subject><subject>Atherosclerosis</subject><subject>Case-Control Studies</subject><subject>Causes of</subject><subject>Chi-Square Distribution</subject><subject>Child</subject><subject>Cholesterol</subject><subject>Coronary artery disease, Atherosclerosis, Inflammatory markers, Genetics, Single nucleotide polymorphism, Tumor necrosis factor receptor type II</subject><subject>Coronary Disease - epidemiology</subject><subject>Coronary Disease - genetics</subject><subject>Coronary heart disease</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Frequency</subject><subject>Gene mutations</subject><subject>Genetic polymorphisms</subject><subject>Genotype</subject><subject>Humans</subject><subject>Incidence</subject><subject>India - epidemiology</subject><subject>Inflammation</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Prospective Studies</subject><subject>Receptors, Tumor Necrosis Factor - genetics</subject><issn>0019-5359</issn><issn>1998-3654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkctLxDAQxoMouj7O3qR48NY1r0mbo4gvEAXRc0jTqUbaZk12D_vfm3VXBZEEBmZ-X_gyHyHHjE4lo-KcUqZLEKCnDGittsiEaV2XQoHcJpOf6R7ZT-mdUi440F2yx6CmoGo6Ifz54fqJF684YjEL_XIIcfbm01D4sXAhhtHGZWHjHHNpfUKb8JDsdLZPeLSpB-Tl-ur58ra8f7y5u7y4LxsBYl62toNGolQKAQVjHGtZYW0ldJRXwjFlW221tLWTrNOKO9k65B1oqWTVoDggZ-t3ZzF8LDDNzeCTw763I4ZFMqpSutYgM3j6B3wPizhmb4ZpAElZpTNUrqFX26PxYxfm0brVv6Ptw4idz-0LJhjnHBhkfvoPn0-Lg3f_Cs7XAhdDShE7M4t-yOszjJpVWGYVh1nFYb7CyoqTje9FM2D7y2_S-fXQ-ND7EX8IF701380h5UuBZg-f76WdDg</recordid><startdate>200503</startdate><enddate>200503</enddate><creator>Sankar VH, Girisha KM, Gilmour A, Singh VP, Sinha N, Tewari S, Ramesh V, Mastana S, Agrawal Suraksha</creator><general>Medknow Publications on behalf of Indian Journal of Medical Sciences Trust</general><general>Medknow Publications and Media Pvt. Ltd</general><general>Medip Academy</general><scope>RBI</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>200503</creationdate><title>TNFR2 gene polymorphism in coronary artery disease</title><author>Sankar VH, Girisha KM, Gilmour A, Singh VP, Sinha N, Tewari S, Ramesh V, Mastana S, Agrawal Suraksha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b353t-daf5b4e466e5e3112e847e8a45f0273c16ad9a94a8c41f962c4dce2f594647be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Alleles</topic><topic>Atherosclerosis</topic><topic>Case-Control Studies</topic><topic>Causes of</topic><topic>Chi-Square Distribution</topic><topic>Child</topic><topic>Cholesterol</topic><topic>Coronary artery disease, Atherosclerosis, Inflammatory markers, Genetics, Single nucleotide polymorphism, Tumor necrosis factor receptor type II</topic><topic>Coronary Disease - epidemiology</topic><topic>Coronary Disease - genetics</topic><topic>Coronary heart disease</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Frequency</topic><topic>Gene mutations</topic><topic>Genetic polymorphisms</topic><topic>Genotype</topic><topic>Humans</topic><topic>Incidence</topic><topic>India - epidemiology</topic><topic>Inflammation</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Prospective Studies</topic><topic>Receptors, Tumor Necrosis Factor - genetics</topic><toplevel>online_resources</toplevel><creatorcontrib>Sankar VH, Girisha KM, Gilmour A, Singh VP, Sinha N, Tewari S, Ramesh V, Mastana S, Agrawal Suraksha</creatorcontrib><collection>Bioline International</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Indian journal of medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sankar VH, Girisha KM, Gilmour A, Singh VP, Sinha N, Tewari S, Ramesh V, Mastana S, Agrawal Suraksha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TNFR2 gene polymorphism in coronary artery disease</atitle><jtitle>Indian journal of medical sciences</jtitle><addtitle>Indian J Med Sci</addtitle><date>2005-03</date><risdate>2005</risdate><volume>59</volume><issue>3</issue><spage>104</spage><epage>108</epage><pages>104-108</pages><issn>0019-5359</issn><eissn>1998-3654</eissn><abstract>BACKGROUND: Recently atherosclerosis and coronary artery disease
(CAD) are considered to be inflammatory diseases. The genetic
polymorphism in inflammatory markers has been well studied and found to
be associated with development of CAD. AIM: To study the association
of biallelic polymorphism at position 196 in exon 6 of tumor necrosis
factor 2 (TNFR2) gene and coronary artery disease. SETTINGS AND
DESIGN: The study design was a prospective case control study
conducted at a tertiary referral center mainly catering to the north
Indian population. MATERIALS AND METHODS: One hundred and fifty
angiographically proven patients with coronary artery disease and one
hundred and fifty age matched controls were genotyped for TNFR2 gene by
polymerase chain reaction followed by analysis of restriction fragment
length polymorphism. STATISTICAL ANALYSIS: Genotype frequencies were
compared in patients and controls by Chi-square test. Binary logistic
regression analysis was used to examine the relationship between
genotypes and disease, incorporating other variables into the model.
RESULTS: The incidence of CAD in those with MM genotype was 65% and in
those with RM genotype was 42%. Genotype frequency shows significant
association of MM genotype with development of CAD (P<0.001; odds
ratio-2.585; 95% confidence interval 1.533-4.359). The association of
TNFR2 genotype with CAD persisted on logistic regression analysis.
CONCLUSION: MM genotype of TNFR2 gene is associated with development
of CAD and RM genotype appears to be protective.</abstract><cop>India</cop><pub>Medknow Publications on behalf of Indian Journal of Medical Sciences Trust</pub><pmid>15805680</pmid><doi>10.4103/0019-5359.15086</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0019-5359 |
| ispartof | Indian journal of medical sciences, 2005-03, Vol.59 (3), p.104-108 |
| issn | 0019-5359 1998-3654 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67698954 |
| source | MEDLINE; Bioline International; EZB Electronic Journals Library |
| subjects | Adolescent Adult Alleles Atherosclerosis Case-Control Studies Causes of Chi-Square Distribution Child Cholesterol Coronary artery disease, Atherosclerosis, Inflammatory markers, Genetics, Single nucleotide polymorphism, Tumor necrosis factor receptor type II Coronary Disease - epidemiology Coronary Disease - genetics Coronary heart disease Female Gene expression Gene Frequency Gene mutations Genetic polymorphisms Genotype Humans Incidence India - epidemiology Inflammation Logistic Models Male Medical research Medicine, Experimental Middle Aged Polymorphism, Genetic Polymorphism, Restriction Fragment Length Prospective Studies Receptors, Tumor Necrosis Factor - genetics |
| title | TNFR2 gene polymorphism in coronary artery disease |
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