Dihydrocucurbitacin B, isolated from Cayaponia tayuya, reduces damage in adjuvant-induced arthritis

23,24-Dihydrocucurbitacin B, from the anti-rheumatic plant Cayaponia tayuya, was tested on arthritis induced by adjuvant to corroborate the anti-inflammatory properties of this plant. Arthritis was induced in Lewis rats; the resulting arthritic rats were then treated with dihydrocucurbitacin B (1 mg...

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Veröffentlicht in:	European journal of pharmacology 2006-02, Vol.532 (1), p.145-154
Hauptverfasser:	Escandell, José Miguel, Recio, María-Carmen, Máñez, Salvador, Giner, Rosa-María, Cerdá-Nicolás, Miguel, Ríos, José-Luis
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant-induced arthritis Administration, Oral Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - therapeutic use Antirheumatic Agents - administration & dosage Antirheumatic Agents - isolation & purification Antirheumatic Agents - therapeutic use Arthritis, Experimental - metabolism Arthritis, Experimental - pathology Arthritis, Experimental - prevention & control Biological and medical sciences Cayaponia tayuya Cell Line Cell Survival - drug effects Cucurbitaceae - chemistry Cyclooxygenase Cyclooxygenase 2 - metabolism Cytokines - metabolism Dihydrocucurbitacin B Dinoprostone - metabolism Diseases of the osteoarticular system Dose-Response Relationship, Drug Enzyme Activation - drug effects Female Interleukin-1β Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes - metabolism Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Medical sciences Miscellaneous. Osteoarticular involvement in other diseases Nitric oxide synthase Nitric Oxide Synthase Type II - metabolism Nitrites - metabolism Pain - prevention & control Pancreatic Elastase - metabolism Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - isolation & purification Plant Extracts - therapeutic use Plant Roots - chemistry Rats Rats, Inbred Lew Superoxides - metabolism Triterpenes - administration & dosage Triterpenes - therapeutic use Tumor necrosis factor-α
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