Eradication of tumors from a human colon cancer cell line and from ovarian cancer metastases in immunodeficient mice by a single-chain Ep-CAM-/CD3-bispecific antibody construct

Bispecific T-cell engager (BiTE) are a class of bispecific single-chain antibodies that can very effectively redirect cytotoxic T cells for killing of tumor target cells. Here, we have assessed the in vivo efficacy of one representative, called bscEp-CAMxCD3, with specificity for tumors overexpressi...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-04, Vol.65 (7), p.2882-2889
Hauptverfasser:	SCHLERETH, Bernd, FICHTNER, Iduna, WIMBERGER, Pauline, KIMMIG, Rainer, BAEUERLE, Patrick A, LORENCZEWSKI, Grit, KLEINDIENST, Petra, BRISCHWEIN, Klaus, DA SILVA, Antonio, KUFER, Peter, LUTTERBUESE, Ralf, JUNGHAHN, Ilse, KASIMIR-BAUER, Sabine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Bispecific - immunology Antibodies, Bispecific - pharmacokinetics Antibodies, Bispecific - pharmacology Antibody Specificity Antigens, Neoplasm - immunology Antineoplastic agents Biological and medical sciences CD3 Complex - immunology Cell Adhesion Molecules - immunology Cell Line, Tumor Colonic Neoplasms - immunology Colonic Neoplasms - therapy Epithelial Cell Adhesion Molecule Female Female genital diseases Gastroenterology. Liver. Pancreas. Abdomen Gynecology. Andrology. Obstetrics Humans Medical sciences Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, SCID Ovarian Neoplasms - immunology Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy Peritoneal Neoplasms - immunology Peritoneal Neoplasms - secondary Peritoneal Neoplasms - therapy Pharmacology. Drug treatments Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors Xenograft Model Antitumor Assays
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