Disseminated adenovirus infection with respiratory failure in pediatric liver transplant recipients: Impact of intravenous cidofovir and inhaled nitric oxide
: Adenoviruses (AdV) are opportunistic pathogens that can lead to severe infections and respiratory failure (acute respiratory distress syndrome, ARDS) with high mortality in immunosuppressed patients. Cidofovir (CDV) has been used in adenoviral disease in bone marrow transplant recipients. Two ped...
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| Veröffentlicht in: | Pediatric transplantation 2006-02, Vol.10 (1), p.121-127 |
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| container_title | Pediatric transplantation |
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| creator | Wallot, M. A. Dohna-Schwake, C. Auth, M. Nadalin, S. Fiedler, M. Malagó, M. Broelsch, C. Voit, T. |
| description | : Adenoviruses (AdV) are opportunistic pathogens that can lead to severe infections and respiratory failure (acute respiratory distress syndrome, ARDS) with high mortality in immunosuppressed patients. Cidofovir (CDV) has been used in adenoviral disease in bone marrow transplant recipients. Two pediatric liver transplant recipients with disseminated adenoviral disease and ARDS were treated with reduction of immunosuppression, CDV, and inhaled nitric oxide (iNO). CDV 1 mg/kg was given three times per week intravenously with intravenous hydration and oral probenecid. Viral suppression and clinical improvement was achieved. AdV hepatitis did not occur, and graft function was preserved, although acute rejection occurred in both patients. Adverse effects were mild and transient not requiring dose modification. Severe hypoxemia was reversed with iNO 10–20 p.p.m. CDV treatment of AdV infections in organ transplant recipients and other immunocompromised patients should be further investigated in prospective studies. |
| doi_str_mv | 10.1111/j.1399-3046.2005.00411.x |
| format | Article |
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A. ; Dohna-Schwake, C. ; Auth, M. ; Nadalin, S. ; Fiedler, M. ; Malagó, M. ; Broelsch, C. ; Voit, T.</creator><creatorcontrib>Wallot, M. A. ; Dohna-Schwake, C. ; Auth, M. ; Nadalin, S. ; Fiedler, M. ; Malagó, M. ; Broelsch, C. ; Voit, T.</creatorcontrib><description>: Adenoviruses (AdV) are opportunistic pathogens that can lead to severe infections and respiratory failure (acute respiratory distress syndrome, ARDS) with high mortality in immunosuppressed patients. Cidofovir (CDV) has been used in adenoviral disease in bone marrow transplant recipients. Two pediatric liver transplant recipients with disseminated adenoviral disease and ARDS were treated with reduction of immunosuppression, CDV, and inhaled nitric oxide (iNO). CDV 1 mg/kg was given three times per week intravenously with intravenous hydration and oral probenecid. Viral suppression and clinical improvement was achieved. AdV hepatitis did not occur, and graft function was preserved, although acute rejection occurred in both patients. Adverse effects were mild and transient not requiring dose modification. Severe hypoxemia was reversed with iNO 10–20 p.p.m. CDV treatment of AdV infections in organ transplant recipients and other immunocompromised patients should be further investigated in prospective studies.</description><identifier>ISSN: 1397-3142</identifier><identifier>EISSN: 1399-3046</identifier><identifier>DOI: 10.1111/j.1399-3046.2005.00411.x</identifier><identifier>PMID: 16499602</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject><![CDATA[acute respiratory distress syndrome ; Adenovirus ; Adenovirus Infections, Human - drug therapy ; Adenovirus Infections, Human - etiology ; Administration, Inhalation ; Antiviral Agents - administration & dosage ; Biliary Atresia - surgery ; Biological and medical sciences ; child ; cidofovir ; Cytosine - administration & dosage ; Cytosine - analogs & derivatives ; Female ; Follow-Up Studies ; Free Radical Scavengers - administration & dosage ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Immunosuppression - adverse effects ; Infant ; Liver Failure, Acute - surgery ; Liver Transplantation ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; nitric oxide ; Nitric Oxide - administration & dosage ; Organophosphonates - administration & dosage ; Other diseases. Semiology ; Pneumology ; polymerase chain reaction ; Postoperative Complications ; Respiratory Insufficiency - drug therapy ; Respiratory Insufficiency - etiology ; Respiratory system : syndromes and miscellaneous diseases ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases]]></subject><ispartof>Pediatric transplantation, 2006-02, Vol.10 (1), p.121-127</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4661-98cd768eeb907094c3145b4960623ecd4e729f38218f7ce5145363a3dac508503</citedby><cites>FETCH-LOGICAL-c4661-98cd768eeb907094c3145b4960623ecd4e729f38218f7ce5145363a3dac508503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1399-3046.2005.00411.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1399-3046.2005.00411.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17590222$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16499602$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wallot, M. A.</creatorcontrib><creatorcontrib>Dohna-Schwake, C.</creatorcontrib><creatorcontrib>Auth, M.</creatorcontrib><creatorcontrib>Nadalin, S.</creatorcontrib><creatorcontrib>Fiedler, M.</creatorcontrib><creatorcontrib>Malagó, M.</creatorcontrib><creatorcontrib>Broelsch, C.</creatorcontrib><creatorcontrib>Voit, T.</creatorcontrib><title>Disseminated adenovirus infection with respiratory failure in pediatric liver transplant recipients: Impact of intravenous cidofovir and inhaled nitric oxide</title><title>Pediatric transplantation</title><addtitle>Pediatr Transplant</addtitle><description>: Adenoviruses (AdV) are opportunistic pathogens that can lead to severe infections and respiratory failure (acute respiratory distress syndrome, ARDS) with high mortality in immunosuppressed patients. Cidofovir (CDV) has been used in adenoviral disease in bone marrow transplant recipients. Two pediatric liver transplant recipients with disseminated adenoviral disease and ARDS were treated with reduction of immunosuppression, CDV, and inhaled nitric oxide (iNO). CDV 1 mg/kg was given three times per week intravenously with intravenous hydration and oral probenecid. Viral suppression and clinical improvement was achieved. AdV hepatitis did not occur, and graft function was preserved, although acute rejection occurred in both patients. Adverse effects were mild and transient not requiring dose modification. Severe hypoxemia was reversed with iNO 10–20 p.p.m. CDV treatment of AdV infections in organ transplant recipients and other immunocompromised patients should be further investigated in prospective studies.</description><subject>acute respiratory distress syndrome</subject><subject>Adenovirus</subject><subject>Adenovirus Infections, Human - drug therapy</subject><subject>Adenovirus Infections, Human - etiology</subject><subject>Administration, Inhalation</subject><subject>Antiviral Agents - administration & dosage</subject><subject>Biliary Atresia - surgery</subject><subject>Biological and medical sciences</subject><subject>child</subject><subject>cidofovir</subject><subject>Cytosine - administration & dosage</subject><subject>Cytosine - analogs & derivatives</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Free Radical Scavengers - administration & dosage</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunosuppression - adverse effects</subject><subject>Infant</subject><subject>Liver Failure, Acute - surgery</subject><subject>Liver Transplantation</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>nitric oxide</subject><subject>Nitric Oxide - administration & dosage</subject><subject>Organophosphonates - administration & dosage</subject><subject>Other diseases. Semiology</subject><subject>Pneumology</subject><subject>polymerase chain reaction</subject><subject>Postoperative Complications</subject><subject>Respiratory Insufficiency - drug therapy</subject><subject>Respiratory Insufficiency - etiology</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><issn>1397-3142</issn><issn>1399-3046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctu1DAUhiMEoqXwCsgb2CX1JXFiJBZoaEulKTcVlZ3lcU5UD7nV9kxnHoZ37cnMqF2CN8fS-f5z-5OEMJoxfKfLjAmlUkFzmXFKi4zSnLFs8yw5fkw83_3LVLCcHyWvQlhSymRe5S-TI4xKScqPk7-fXQjQud5EqImpoR_Wzq8CcX0DNrqhJ_cu3hIPYXTexMFvSWNcu_KACBmhdiZ6Z0nr1uBJ9KYPY2v6iArrRgd9DB_IZTcaG8nQoAaRNXbBFtbVQzO1I6avMXNrWpyhd7t6w8bV8Dp50Zg2wJtDPEl-nZ9dz76k828Xl7NP89TmUrJUVbYuZQWwULSkKre4c7HIcUPJBdg6h5KrRlScVU1pocCskMKI2tiCVgUVJ8n7fd3RD3crCFF3LlhocRHASbUspSrzUv4T5LSSnHKFYLUHrR9C8NDo0bvO-K1mVE8e6qWerNKTVXryUO881BuUvj30WC06qJ-EB9MQeHcATLCmbfDm1oUnriwU5XziPu65e9fC9r8H0N_Prn_iD_XpXu9ChM2j3vg_eBBRFvrm64Wesaub899Xc_1DPABZk8pa</recordid><startdate>200602</startdate><enddate>200602</enddate><creator>Wallot, M. A.</creator><creator>Dohna-Schwake, C.</creator><creator>Auth, M.</creator><creator>Nadalin, S.</creator><creator>Fiedler, M.</creator><creator>Malagó, M.</creator><creator>Broelsch, C.</creator><creator>Voit, T.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200602</creationdate><title>Disseminated adenovirus infection with respiratory failure in pediatric liver transplant recipients: Impact of intravenous cidofovir and inhaled nitric oxide</title><author>Wallot, M. A. ; Dohna-Schwake, C. ; Auth, M. ; Nadalin, S. ; Fiedler, M. ; Malagó, M. ; Broelsch, C. ; Voit, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4661-98cd768eeb907094c3145b4960623ecd4e729f38218f7ce5145363a3dac508503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>acute respiratory distress syndrome</topic><topic>Adenovirus</topic><topic>Adenovirus Infections, Human - drug therapy</topic><topic>Adenovirus Infections, Human - etiology</topic><topic>Administration, Inhalation</topic><topic>Antiviral Agents - administration & dosage</topic><topic>Biliary Atresia - surgery</topic><topic>Biological and medical sciences</topic><topic>child</topic><topic>cidofovir</topic><topic>Cytosine - administration & dosage</topic><topic>Cytosine - analogs & derivatives</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Free Radical Scavengers - administration & dosage</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Immunosuppression - adverse effects</topic><topic>Infant</topic><topic>Liver Failure, Acute - surgery</topic><topic>Liver Transplantation</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>nitric oxide</topic><topic>Nitric Oxide - administration & dosage</topic><topic>Organophosphonates - administration & dosage</topic><topic>Other diseases. Semiology</topic><topic>Pneumology</topic><topic>polymerase chain reaction</topic><topic>Postoperative Complications</topic><topic>Respiratory Insufficiency - drug therapy</topic><topic>Respiratory Insufficiency - etiology</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wallot, M. A.</creatorcontrib><creatorcontrib>Dohna-Schwake, C.</creatorcontrib><creatorcontrib>Auth, M.</creatorcontrib><creatorcontrib>Nadalin, S.</creatorcontrib><creatorcontrib>Fiedler, M.</creatorcontrib><creatorcontrib>Malagó, M.</creatorcontrib><creatorcontrib>Broelsch, C.</creatorcontrib><creatorcontrib>Voit, T.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wallot, M. A.</au><au>Dohna-Schwake, C.</au><au>Auth, M.</au><au>Nadalin, S.</au><au>Fiedler, M.</au><au>Malagó, M.</au><au>Broelsch, C.</au><au>Voit, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disseminated adenovirus infection with respiratory failure in pediatric liver transplant recipients: Impact of intravenous cidofovir and inhaled nitric oxide</atitle><jtitle>Pediatric transplantation</jtitle><addtitle>Pediatr Transplant</addtitle><date>2006-02</date><risdate>2006</risdate><volume>10</volume><issue>1</issue><spage>121</spage><epage>127</epage><pages>121-127</pages><issn>1397-3142</issn><eissn>1399-3046</eissn><abstract>: Adenoviruses (AdV) are opportunistic pathogens that can lead to severe infections and respiratory failure (acute respiratory distress syndrome, ARDS) with high mortality in immunosuppressed patients. Cidofovir (CDV) has been used in adenoviral disease in bone marrow transplant recipients. Two pediatric liver transplant recipients with disseminated adenoviral disease and ARDS were treated with reduction of immunosuppression, CDV, and inhaled nitric oxide (iNO). CDV 1 mg/kg was given three times per week intravenously with intravenous hydration and oral probenecid. Viral suppression and clinical improvement was achieved. AdV hepatitis did not occur, and graft function was preserved, although acute rejection occurred in both patients. Adverse effects were mild and transient not requiring dose modification. Severe hypoxemia was reversed with iNO 10–20 p.p.m. CDV treatment of AdV infections in organ transplant recipients and other immunocompromised patients should be further investigated in prospective studies.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16499602</pmid><doi>10.1111/j.1399-3046.2005.00411.x</doi><tpages>7</tpages></addata></record> |
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| ispartof | Pediatric transplantation, 2006-02, Vol.10 (1), p.121-127 |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | acute respiratory distress syndrome Adenovirus Adenovirus Infections, Human - drug therapy Adenovirus Infections, Human - etiology Administration, Inhalation Antiviral Agents - administration & dosage Biliary Atresia - surgery Biological and medical sciences child cidofovir Cytosine - administration & dosage Cytosine - analogs & derivatives Female Follow-Up Studies Free Radical Scavengers - administration & dosage Gastroenterology. Liver. Pancreas. Abdomen Humans Immunosuppression - adverse effects Infant Liver Failure, Acute - surgery Liver Transplantation Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences nitric oxide Nitric Oxide - administration & dosage Organophosphonates - administration & dosage Other diseases. Semiology Pneumology polymerase chain reaction Postoperative Complications Respiratory Insufficiency - drug therapy Respiratory Insufficiency - etiology Respiratory system : syndromes and miscellaneous diseases Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases |
| title | Disseminated adenovirus infection with respiratory failure in pediatric liver transplant recipients: Impact of intravenous cidofovir and inhaled nitric oxide |
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