Behaviour changes in a transgenic model of Huntington's disease

Huntington's disease is an autosomal dominant inherited disorder, caused by an expanded polyglutamine region of a protein called huntingtin with unknown function. Transgenic mice expressing the N-terminal of huntingtin, containing 82 glutamines, exhibit a progressive disorder, which resembles t...

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Veröffentlicht in:	Behavioural brain research 2006-04, Vol.169 (1), p.137-141
Hauptverfasser:	Klivenyi, Peter, Bende, Zsuzsanna, Hartai, Zsuzsanna, Penke, Zsuzsanna, Nemeth, Hajnalka, Toldi, Jozsef, Vecsei, Laszlo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Animals Anxiety Anxiety - genetics Anxiety - metabolism Behavior, Animal - physiology Behaviour changes Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Explorative behaviour Exploratory Behavior - physiology Grooming - physiology Humans Huntingtin Protein Huntington Disease - genetics Huntington Disease - physiopathology Huntington's disease Immobility Response, Tonic - physiology Male Medical sciences Mice Mice, Transgenic Motor performance Motor Skills - physiology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurology Nuclear Proteins - genetics Nuclear Proteins - metabolism Organic mental disorders. Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rotarod Performance Test Stereotyped Behavior - physiology Transgenic mice
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