Dominant-negative Rac1 suppresses Ras-induced apoptosis possibly through activation of NFkappaB in Ha-ras oncogene-transformed NIH/3T3 cells

We investigated the involvement of Rac1 in Ha-ras-overexpression-induced apoptosis using a murine NIH/3T3-derived cell line (designated 7-4), which contains an inducible Ha-ras oncogene under the regulation of Escherichia coli lac operator-repressor system. Ha-ras overexpression was induced by isopr...

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Veröffentlicht in:	Life sciences (1973) 2006-03, Vol.78 (16), p.1823-1829
Hauptverfasser:	Chou, Chao-Kai, Liang, Kuo-Hsuan, Tzeng, Ching-Chang, Huang, Guan-Cheng, Chuang, Jih-I, Chang, Tsuey-Yu, Liu, Hsiao-Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Apoptosis Blotting, Northern Cell Line, Transformed Electrophoretic Mobility Shift Assay Genes, Dominant - physiology Genes, ras - physiology Humans Immunoprecipitation Isopropyl Thiogalactoside - pharmacology Mice NF-kappa B - genetics NF-kappa B - metabolism rac1 GTP-Binding Protein - physiology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism S Phase Signal Transduction Transgenes - physiology
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