pyrimidine-β-carboline and other alkaloids from Annona foetida with antileishmanial activity

Bioassay-guided fractionation of the bark extract of Annona foetida afforded a new antileishmanial pyrimidine-beta-carboline alkaloid, N-hydroxyannomontine (1), together with the previously reported annomontine (2), O-methylmoschatoline (3), and liriodenine (4). The structure of compound 1 was estab...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2006-02, Vol.69 (2), p.292-294
Hauptverfasser:	Costa, E.V, Pinheiro, M.L.B, Xavier, C.M, Silva, J.R.A, Amaral, A.C.F, Souza, A.D.L, Barison, A, Campos, F.R, Ferreira, A.G, Machado, G.M.C
Format:	Artikel
Sprache:	eng
Schlagworte:	alkaloids Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Animals Annona Annona - chemistry Annona foetida Antiprotozoal Agents - chemistry Antiprotozoal Agents - isolation & purification Antiprotozoal Agents - pharmacology Biological and medical sciences Brazil Carbolines - chemistry Carbolines - isolation & purification Carbolines - pharmacology chemical structure General pharmacology Leishmania - drug effects Leishmania braziliensis Lishmania guyanensis Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry pyrimidine-beta-carboline pyrimidines Pyrimidines - chemistry Pyrimidines - isolation & purification Pyrimidines - pharmacology spectral analysis stereochemistry
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