Acute bacterial meningitis in Qatar
To study the changes in the epidemiology, clinical and bacteriological profiles of bacterial meningitis in the era of the Haemophilus influenzae type b (Hib)vaccine and pneumococcus resistance. This is a retrospective study of children aged
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| Veröffentlicht in: | Saudi medical journal 2006-02, Vol.27 (2), p.198-204 |
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| container_title | Saudi medical journal |
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| creator | ELSAID, Mahmoud F FLAMERZI, Aminaa BESSISSO, Mohammed S ELSHAFIE, Sittana S |
| description | To study the changes in the epidemiology, clinical and bacteriological profiles of bacterial meningitis in the era of the Haemophilus influenzae type b (Hib)vaccine and pneumococcus resistance.
This is a retrospective study of children aged |
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This is a retrospective study of children aged <12 years admitted to the Hamad Medical Corporation, Qatar between January 1998 through December 2002 with positive cerebrospinal fluid culture.
We described 64 patients with culture proven bacterial meningitis. In infants <3 months (n=29 [45%]), the most common organism was Group B Streptococcus (GBS) (20%). Children >3 months (n=35 [55%]); Hib (25%) and Streptococcus pneumoniae (STP) (20%) were the most common organisms before introduction of Hib vaccination. A significant drop of Hib infections were noticed after introduction of the vaccine. Fever, neck stiffness, seizure, vomiting, and bulging fontanel were the most frequent presenting features. Group B Streptococcus were sensitive to ampicillin and cefotaxime with no resistance detected. Forty percent of STP isolates were resistant to penicillin and 12% were resistant to ceftriaxone. Fifty percent of Hib were resistant to ampicillin; while none of Hib were resistant to ceftriaxone. No case of Listeria monocytogenes meningitis was diagnosed. Morbidity was 28%, and one patient expired (2%) after Klebsiella pneumoniae meningitis. Streptococcus pneumoniae was associated with the highest morbidity (62%) while Hib had zero morbidity in our patients.
Bacterial meningitis is a serious illness with a significant morbidity and mortality. Haemophilus influenzae type b infection decreased which indicated an effective vaccination. As there is 12% bacterial resistance of STP reported against ceftriaxone; We recommend Cefotaxime for infants <3 months while ceftriaxone plus vancomycin as empiric therapy for older patients with community acquired bacterial meningitis. A pneumococcal vaccination may further decrease the incidence of meningitis in our community. A continuos surveillance to detect changes in the microbiology of organisms causing bacterial meningitis or their sensitivity in our community is essential to update these recommendations.</description><identifier>ISSN: 0379-5284</identifier><identifier>PMID: 16501676</identifier><identifier>CODEN: SAMJDI</identifier><language>eng</language><publisher>Riyadh: Saudi Medical Journal</publisher><subject>Acute Disease ; Biological and medical sciences ; Child ; Child, Preschool ; General aspects ; Haemophilus Infections - epidemiology ; Humans ; Infant ; Medical sciences ; Meningitis, Bacterial - epidemiology ; Qatar - epidemiology ; Retrospective Studies ; Streptococcal Infections - epidemiology</subject><ispartof>Saudi medical journal, 2006-02, Vol.27 (2), p.198-204</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17492295$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16501676$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ELSAID, Mahmoud F</creatorcontrib><creatorcontrib>FLAMERZI, Aminaa</creatorcontrib><creatorcontrib>BESSISSO, Mohammed S</creatorcontrib><creatorcontrib>ELSHAFIE, Sittana S</creatorcontrib><title>Acute bacterial meningitis in Qatar</title><title>Saudi medical journal</title><addtitle>Saudi Med J</addtitle><description>To study the changes in the epidemiology, clinical and bacteriological profiles of bacterial meningitis in the era of the Haemophilus influenzae type b (Hib)vaccine and pneumococcus resistance.
This is a retrospective study of children aged <12 years admitted to the Hamad Medical Corporation, Qatar between January 1998 through December 2002 with positive cerebrospinal fluid culture.
We described 64 patients with culture proven bacterial meningitis. In infants <3 months (n=29 [45%]), the most common organism was Group B Streptococcus (GBS) (20%). Children >3 months (n=35 [55%]); Hib (25%) and Streptococcus pneumoniae (STP) (20%) were the most common organisms before introduction of Hib vaccination. A significant drop of Hib infections were noticed after introduction of the vaccine. Fever, neck stiffness, seizure, vomiting, and bulging fontanel were the most frequent presenting features. Group B Streptococcus were sensitive to ampicillin and cefotaxime with no resistance detected. Forty percent of STP isolates were resistant to penicillin and 12% were resistant to ceftriaxone. Fifty percent of Hib were resistant to ampicillin; while none of Hib were resistant to ceftriaxone. No case of Listeria monocytogenes meningitis was diagnosed. Morbidity was 28%, and one patient expired (2%) after Klebsiella pneumoniae meningitis. Streptococcus pneumoniae was associated with the highest morbidity (62%) while Hib had zero morbidity in our patients.
Bacterial meningitis is a serious illness with a significant morbidity and mortality. Haemophilus influenzae type b infection decreased which indicated an effective vaccination. As there is 12% bacterial resistance of STP reported against ceftriaxone; We recommend Cefotaxime for infants <3 months while ceftriaxone plus vancomycin as empiric therapy for older patients with community acquired bacterial meningitis. A pneumococcal vaccination may further decrease the incidence of meningitis in our community. A continuos surveillance to detect changes in the microbiology of organisms causing bacterial meningitis or their sensitivity in our community is essential to update these recommendations.</description><subject>Acute Disease</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>General aspects</subject><subject>Haemophilus Infections - epidemiology</subject><subject>Humans</subject><subject>Infant</subject><subject>Medical sciences</subject><subject>Meningitis, Bacterial - epidemiology</subject><subject>Qatar - epidemiology</subject><subject>Retrospective Studies</subject><subject>Streptococcal Infections - epidemiology</subject><issn>0379-5284</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFz0tLxDAUhuEsFGcc_QtSEN0VcmlzWQ6DNxgQYfblTHIikTZTk3Thv7dixdXZPLwf54ysqVCmbrluVuQy5w9KhZRUXpAVky1lUsk1ud3aqWB1BFswBeirAWOI76GEXIVYvUGBdEXOPfQZr5e7IYfHh8Puud6_Pr3stvt65MKUeg5qSqV21ivrBdeCzxMOmDTcaYXaM-E0Z65hxqKRXAnhBQCnDqnRYkPuf7NjOn1OmEs3hGyx7yHiacrdHDNtq3_gzQKn44CuG1MYIH11f1_N4G4BkC30PkG0If871RjOTSu-AU12UkY</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>ELSAID, Mahmoud F</creator><creator>FLAMERZI, Aminaa</creator><creator>BESSISSO, Mohammed S</creator><creator>ELSHAFIE, Sittana S</creator><general>Saudi Medical Journal</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20060201</creationdate><title>Acute bacterial meningitis in Qatar</title><author>ELSAID, Mahmoud F ; FLAMERZI, Aminaa ; BESSISSO, Mohammed S ; ELSHAFIE, Sittana S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-16780068dcf7cf32832676da1692d87e8f13d821d419ce962733f3aa20de0983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acute Disease</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>General aspects</topic><topic>Haemophilus Infections - epidemiology</topic><topic>Humans</topic><topic>Infant</topic><topic>Medical sciences</topic><topic>Meningitis, Bacterial - epidemiology</topic><topic>Qatar - epidemiology</topic><topic>Retrospective Studies</topic><topic>Streptococcal Infections - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ELSAID, Mahmoud F</creatorcontrib><creatorcontrib>FLAMERZI, Aminaa</creatorcontrib><creatorcontrib>BESSISSO, Mohammed S</creatorcontrib><creatorcontrib>ELSHAFIE, Sittana S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Saudi medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ELSAID, Mahmoud F</au><au>FLAMERZI, Aminaa</au><au>BESSISSO, Mohammed S</au><au>ELSHAFIE, Sittana S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute bacterial meningitis in Qatar</atitle><jtitle>Saudi medical journal</jtitle><addtitle>Saudi Med J</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>27</volume><issue>2</issue><spage>198</spage><epage>204</epage><pages>198-204</pages><issn>0379-5284</issn><coden>SAMJDI</coden><abstract>To study the changes in the epidemiology, clinical and bacteriological profiles of bacterial meningitis in the era of the Haemophilus influenzae type b (Hib)vaccine and pneumococcus resistance.
This is a retrospective study of children aged <12 years admitted to the Hamad Medical Corporation, Qatar between January 1998 through December 2002 with positive cerebrospinal fluid culture.
We described 64 patients with culture proven bacterial meningitis. In infants <3 months (n=29 [45%]), the most common organism was Group B Streptococcus (GBS) (20%). Children >3 months (n=35 [55%]); Hib (25%) and Streptococcus pneumoniae (STP) (20%) were the most common organisms before introduction of Hib vaccination. A significant drop of Hib infections were noticed after introduction of the vaccine. Fever, neck stiffness, seizure, vomiting, and bulging fontanel were the most frequent presenting features. Group B Streptococcus were sensitive to ampicillin and cefotaxime with no resistance detected. Forty percent of STP isolates were resistant to penicillin and 12% were resistant to ceftriaxone. Fifty percent of Hib were resistant to ampicillin; while none of Hib were resistant to ceftriaxone. No case of Listeria monocytogenes meningitis was diagnosed. Morbidity was 28%, and one patient expired (2%) after Klebsiella pneumoniae meningitis. Streptococcus pneumoniae was associated with the highest morbidity (62%) while Hib had zero morbidity in our patients.
Bacterial meningitis is a serious illness with a significant morbidity and mortality. Haemophilus influenzae type b infection decreased which indicated an effective vaccination. As there is 12% bacterial resistance of STP reported against ceftriaxone; We recommend Cefotaxime for infants <3 months while ceftriaxone plus vancomycin as empiric therapy for older patients with community acquired bacterial meningitis. A pneumococcal vaccination may further decrease the incidence of meningitis in our community. A continuos surveillance to detect changes in the microbiology of organisms causing bacterial meningitis or their sensitivity in our community is essential to update these recommendations.</abstract><cop>Riyadh</cop><pub>Saudi Medical Journal</pub><pmid>16501676</pmid><tpages>7</tpages></addata></record> |
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| ispartof | Saudi medical journal, 2006-02, Vol.27 (2), p.198-204 |
| issn | 0379-5284 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acute Disease Biological and medical sciences Child Child, Preschool General aspects Haemophilus Infections - epidemiology Humans Infant Medical sciences Meningitis, Bacterial - epidemiology Qatar - epidemiology Retrospective Studies Streptococcal Infections - epidemiology |
| title | Acute bacterial meningitis in Qatar |
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