Dam methylation: coordinating cellular processes
GATC sequences in Escherichia coli DNA are methylated at the adenine residue by DNA adenine methyltransferase (DamMT). These methylated residues and/or the level of DamMT can influence cellular functions such as gene transcription, DNA mismatch repair, initiation of chromosome replication and nucleo...
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| Veröffentlicht in: | Current opinion in microbiology 2005-04, Vol.8 (2), p.154-160 |
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| creator | Løbner-Olesen, Anders Skovgaard, Ole Marinus, Martin G |
| description | GATC sequences in
Escherichia coli DNA are methylated at the adenine residue by DNA adenine methyltransferase (DamMT). These methylated residues and/or the level of DamMT can influence cellular functions such as gene transcription, DNA mismatch repair, initiation of chromosome replication and nucleoid structure. In certain bacteria, unlike
E. coli, DamMT is essential for viability perhaps owing to its role in chromosome replication. DamMT has also been implicated as a virulence factor in bacterial pathogenesis. The origin and phylogeny of DamMT, based on sequenced genomes, has been deduced. |
| doi_str_mv | 10.1016/j.mib.2005.02.009 |
| format | Article |
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Escherichia coli DNA are methylated at the adenine residue by DNA adenine methyltransferase (DamMT). These methylated residues and/or the level of DamMT can influence cellular functions such as gene transcription, DNA mismatch repair, initiation of chromosome replication and nucleoid structure. In certain bacteria, unlike
E. coli, DamMT is essential for viability perhaps owing to its role in chromosome replication. DamMT has also been implicated as a virulence factor in bacterial pathogenesis. The origin and phylogeny of DamMT, based on sequenced genomes, has been deduced.</description><identifier>ISSN: 1369-5274</identifier><identifier>EISSN: 1879-0364</identifier><identifier>DOI: 10.1016/j.mib.2005.02.009</identifier><identifier>PMID: 15802246</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Bacterial Physiological Phenomena ; DNA Methylation ; DNA, Bacterial - metabolism ; Escherichia coli Proteins ; Gene Expression Regulation, Bacterial ; Site-Specific DNA-Methyltransferase (Adenine-Specific) - genetics ; Site-Specific DNA-Methyltransferase (Adenine-Specific) - physiology</subject><ispartof>Current opinion in microbiology, 2005-04, Vol.8 (2), p.154-160</ispartof><rights>2005 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-5f77b919fc10e3fd9e833a1205ca257d5a9833163d192a18f13f865597894c513</citedby><cites>FETCH-LOGICAL-c351t-5f77b919fc10e3fd9e833a1205ca257d5a9833163d192a18f13f865597894c513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1369527405000202$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15802246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Løbner-Olesen, Anders</creatorcontrib><creatorcontrib>Skovgaard, Ole</creatorcontrib><creatorcontrib>Marinus, Martin G</creatorcontrib><title>Dam methylation: coordinating cellular processes</title><title>Current opinion in microbiology</title><addtitle>Curr Opin Microbiol</addtitle><description>GATC sequences in
Escherichia coli DNA are methylated at the adenine residue by DNA adenine methyltransferase (DamMT). These methylated residues and/or the level of DamMT can influence cellular functions such as gene transcription, DNA mismatch repair, initiation of chromosome replication and nucleoid structure. In certain bacteria, unlike
E. coli, DamMT is essential for viability perhaps owing to its role in chromosome replication. DamMT has also been implicated as a virulence factor in bacterial pathogenesis. The origin and phylogeny of DamMT, based on sequenced genomes, has been deduced.</description><subject>Bacterial Physiological Phenomena</subject><subject>DNA Methylation</subject><subject>DNA, Bacterial - metabolism</subject><subject>Escherichia coli Proteins</subject><subject>Gene Expression Regulation, Bacterial</subject><subject>Site-Specific DNA-Methyltransferase (Adenine-Specific) - genetics</subject><subject>Site-Specific DNA-Methyltransferase (Adenine-Specific) - physiology</subject><issn>1369-5274</issn><issn>1879-0364</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwAWxQVuwSZuzYiWGFylOqxAbWluM44CqPYidI_XtctRI7VjNj3XvHcwi5RMgQUNyss85VGQXgGdAMQB6ROZaFTIGJ_Dj2TMiU0yKfkbMQ1gCQSy5OyQx5CZTmYk7gQXdJZ8evbatHN_S3iRkGX7s-Tv1nYmzbTq32ycYPxoZgwzk5aXQb7MWhLsjH0-P78iVdvT2_Lu9XqWEcx5Q3RVFJlI1BsKyppS0Z00iBG015UXMt4wMKVqOkGssGWVMKzmVRytxwZAtyvc-Nm78nG0bVubD7ju7tMAUlCiE5KyEKcS80fgjB20ZtvOu03yoEtcOk1tFaqR0mBVRFTNFzdQifqs7Wf44Dlyi42wtsPPHHWa-CcbY3tnbemlHVg_sn_hcbIXZ1</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>Løbner-Olesen, Anders</creator><creator>Skovgaard, Ole</creator><creator>Marinus, Martin G</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050401</creationdate><title>Dam methylation: coordinating cellular processes</title><author>Løbner-Olesen, Anders ; Skovgaard, Ole ; Marinus, Martin G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-5f77b919fc10e3fd9e833a1205ca257d5a9833163d192a18f13f865597894c513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Bacterial Physiological Phenomena</topic><topic>DNA Methylation</topic><topic>DNA, Bacterial - metabolism</topic><topic>Escherichia coli Proteins</topic><topic>Gene Expression Regulation, Bacterial</topic><topic>Site-Specific DNA-Methyltransferase (Adenine-Specific) - genetics</topic><topic>Site-Specific DNA-Methyltransferase (Adenine-Specific) - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Løbner-Olesen, Anders</creatorcontrib><creatorcontrib>Skovgaard, Ole</creatorcontrib><creatorcontrib>Marinus, Martin G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current opinion in microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Løbner-Olesen, Anders</au><au>Skovgaard, Ole</au><au>Marinus, Martin G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dam methylation: coordinating cellular processes</atitle><jtitle>Current opinion in microbiology</jtitle><addtitle>Curr Opin Microbiol</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>8</volume><issue>2</issue><spage>154</spage><epage>160</epage><pages>154-160</pages><issn>1369-5274</issn><eissn>1879-0364</eissn><abstract>GATC sequences in
Escherichia coli DNA are methylated at the adenine residue by DNA adenine methyltransferase (DamMT). These methylated residues and/or the level of DamMT can influence cellular functions such as gene transcription, DNA mismatch repair, initiation of chromosome replication and nucleoid structure. In certain bacteria, unlike
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| ispartof | Current opinion in microbiology, 2005-04, Vol.8 (2), p.154-160 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Bacterial Physiological Phenomena DNA Methylation DNA, Bacterial - metabolism Escherichia coli Proteins Gene Expression Regulation, Bacterial Site-Specific DNA-Methyltransferase (Adenine-Specific) - genetics Site-Specific DNA-Methyltransferase (Adenine-Specific) - physiology |
| title | Dam methylation: coordinating cellular processes |
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