COX-2 Inhibition Improves Immune System Homeostasis and Decreases Liver Damage in Septic Rats

Objective To evaluate cyclooxygenase-2 (COX-2) inhibition by NS-398 in septic rats with respect to immunologic derangements and hepatic damage. Methods Six sham rats (Sham), 24 rats that underwent experimentally induced sepsis using cecal ligation and puncture (CLP), and 24 rats that underwent induc...

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Veröffentlicht in:	The Journal of surgical research 2009-11, Vol.157 (1), p.43-47
Hauptverfasser:	Li, Bin, M.M, Li, Yu Min, Ph.D., M.D, Li, Xun, M.D, Shi, Bin, M.D, He, Ming Yan, M.M, Zhu, Xiao Liang, M.M, Zhou, Wen Ce, M.D, Wachtel, Mitchell S., M.D, Frezza, Eldo, M.D., M.B.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial diseases Bacterial sepsis Biological and medical sciences Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - pharmacology cyclooxygenase-2 cytokines Cytokines - immunology General aspects Hepatocytes - pathology Hepatocytes - ultrastructure Homeostasis - drug effects Homeostasis - immunology Human bacterial diseases Infectious diseases liver damage Liver Diseases - drug therapy Liver Diseases - immunology Liver Diseases - metabolism Male Medical sciences Microscopy, Electron Nitrobenzenes - pharmacology NS-398 Rats Rats, Wistar RNA, Messenger - metabolism sepsis Sepsis - drug therapy Sepsis - immunology Sepsis - metabolism Sulfonamides - pharmacology Surgery T cells T-Lymphocytes - drug effects T-Lymphocytes - immunology
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