Effects of Salvia officinalis L. (sage) leaves on memory retention and its interaction with the cholinergic system in rats
The leaves of sage ( Salvia officinalis L., Lamiaceae) are reported to have a wide range of biological activities, such as anti-bacterial, fungistatic, virustatic, astringent, eupeptic and anti-hydrotic effects. To determine the mnemogenic effect of sage leaves, we investigated the effects of ethano...
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| Veröffentlicht in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2006-03, Vol.22 (3), p.321-326 |
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| creator | Eidi, Maryam Eidi, Akram Bahar, Massih |
| description | The leaves of sage (
Salvia officinalis L., Lamiaceae) are reported to have a wide range of biological activities, such as anti-bacterial, fungistatic, virustatic, astringent, eupeptic and anti-hydrotic effects. To determine the mnemogenic effect of sage leaves, we investigated the effects of ethanolic extract of sage leaves and its interaction with cholinergic system on memory retention of passive avoidance learning in rats.
Post-training intracerebroventricular (i.c.v) injections were carried out in all the experiments except ethanolic extract (i.p. intraperitoneally).
Administration of ethanolic extract (50 mg/kg), pilocarpine (0.5 and 1 mg/rat), the muscarinic cholinoceptor agonist, and nicotine (0.1 and 1 μg/rat) increased, while mecamylamine (1, 5 μg/rat), the muscarinic cholinoceptor antagonist, and mecamylamine (0.01 and 0.1 μg/rat), the nicotine cholinoceptor antagonist decreased memory retention in rats. Activation of muscarinic cholinoceptors by pilocarpine potentiated the response of ethanolic extract. Also, pharmacological blockade of scopolamine attenuated potentiating effect of ethanolic extract. Activation of nicotinic cholinoceptor by nicotine potentiated the response of ethanolic extract. Blockade of nicotinic cholinoceptor by mecamylamine attenuated the response of ethanolic extract.
It is concluded that the ethanolic extract of salvia officinalis potentiated memory retention and also it has an interaction with muscarinic and nicotinic cholinergic systems that is involved in the memory retention process. |
| doi_str_mv | 10.1016/j.nut.2005.06.010 |
| format | Article |
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Salvia officinalis L., Lamiaceae) are reported to have a wide range of biological activities, such as anti-bacterial, fungistatic, virustatic, astringent, eupeptic and anti-hydrotic effects. To determine the mnemogenic effect of sage leaves, we investigated the effects of ethanolic extract of sage leaves and its interaction with cholinergic system on memory retention of passive avoidance learning in rats.
Post-training intracerebroventricular (i.c.v) injections were carried out in all the experiments except ethanolic extract (i.p. intraperitoneally).
Administration of ethanolic extract (50 mg/kg), pilocarpine (0.5 and 1 mg/rat), the muscarinic cholinoceptor agonist, and nicotine (0.1 and 1 μg/rat) increased, while mecamylamine (1, 5 μg/rat), the muscarinic cholinoceptor antagonist, and mecamylamine (0.01 and 0.1 μg/rat), the nicotine cholinoceptor antagonist decreased memory retention in rats. Activation of muscarinic cholinoceptors by pilocarpine potentiated the response of ethanolic extract. Also, pharmacological blockade of scopolamine attenuated potentiating effect of ethanolic extract. Activation of nicotinic cholinoceptor by nicotine potentiated the response of ethanolic extract. Blockade of nicotinic cholinoceptor by mecamylamine attenuated the response of ethanolic extract.
It is concluded that the ethanolic extract of salvia officinalis potentiated memory retention and also it has an interaction with muscarinic and nicotinic cholinergic systems that is involved in the memory retention process.</description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2005.06.010</identifier><identifier>PMID: 16500558</identifier><identifier>CODEN: NUTRER</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Alzheimer's disease ; Andorra ; Animal cognition ; Animals ; antibacterial properties ; antifungal properties ; antiviral properties ; astringency ; Avoidance Learning - drug effects ; Avoidance Learning - physiology ; Biological and medical sciences ; cholinergic agents ; Cholinergic Antagonists - metabolism ; cognition ; Dose-Response Relationship, Drug ; ethanol ; Feeding. Feeding behavior ; Free radicals ; Fundamental and applied biological sciences. Psychology ; Injections, Intraperitoneal ; leaves ; Male ; Medical research ; medicinal plants ; memory ; Memory - drug effects ; Memory - physiology ; Memory retention ; mnemogenic effect ; Muscarinic Agonists - metabolism ; Muscarinic cholinoceptor ; niacin ; Nicotine ; Nicotine - agonists ; Nicotine - antagonists & inhibitors ; Nicotine - metabolism ; Nicotinic Agonists - metabolism ; Nicotinic cholinoceptor ; Pilocarpine - agonists ; Pilocarpine - antagonists & inhibitors ; Pilocarpine - metabolism ; plant extracts ; Plant Extracts - pharmacology ; Plant Leaves - chemistry ; Plant sciences ; Rat ; Rats ; Rats, Wistar ; Receptors, Cholinergic - drug effects ; Receptors, Cholinergic - metabolism ; Retention ; Rodents ; Sage ; Salvia officinalis ; Salvia officinalis - chemistry ; supercritical fluid extraction ; Teacher education ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2006-03, Vol.22 (3), p.321-326</ispartof><rights>2006 Elsevier Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-d8a8c801d3c07cb2caea8ee1f0d0b8e0bbf30592a8739c3e25bae5d47f17efb63</citedby><cites>FETCH-LOGICAL-c433t-d8a8c801d3c07cb2caea8ee1f0d0b8e0bbf30592a8739c3e25bae5d47f17efb63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0899900705002947$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17894594$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16500558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eidi, Maryam</creatorcontrib><creatorcontrib>Eidi, Akram</creatorcontrib><creatorcontrib>Bahar, Massih</creatorcontrib><title>Effects of Salvia officinalis L. (sage) leaves on memory retention and its interaction with the cholinergic system in rats</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description>The leaves of sage (
Salvia officinalis L., Lamiaceae) are reported to have a wide range of biological activities, such as anti-bacterial, fungistatic, virustatic, astringent, eupeptic and anti-hydrotic effects. To determine the mnemogenic effect of sage leaves, we investigated the effects of ethanolic extract of sage leaves and its interaction with cholinergic system on memory retention of passive avoidance learning in rats.
Post-training intracerebroventricular (i.c.v) injections were carried out in all the experiments except ethanolic extract (i.p. intraperitoneally).
Administration of ethanolic extract (50 mg/kg), pilocarpine (0.5 and 1 mg/rat), the muscarinic cholinoceptor agonist, and nicotine (0.1 and 1 μg/rat) increased, while mecamylamine (1, 5 μg/rat), the muscarinic cholinoceptor antagonist, and mecamylamine (0.01 and 0.1 μg/rat), the nicotine cholinoceptor antagonist decreased memory retention in rats. Activation of muscarinic cholinoceptors by pilocarpine potentiated the response of ethanolic extract. Also, pharmacological blockade of scopolamine attenuated potentiating effect of ethanolic extract. Activation of nicotinic cholinoceptor by nicotine potentiated the response of ethanolic extract. Blockade of nicotinic cholinoceptor by mecamylamine attenuated the response of ethanolic extract.
It is concluded that the ethanolic extract of salvia officinalis potentiated memory retention and also it has an interaction with muscarinic and nicotinic cholinergic systems that is involved in the memory retention process.</description><subject>Alzheimer's disease</subject><subject>Andorra</subject><subject>Animal cognition</subject><subject>Animals</subject><subject>antibacterial properties</subject><subject>antifungal properties</subject><subject>antiviral properties</subject><subject>astringency</subject><subject>Avoidance Learning - drug effects</subject><subject>Avoidance Learning - physiology</subject><subject>Biological and medical sciences</subject><subject>cholinergic agents</subject><subject>Cholinergic Antagonists - metabolism</subject><subject>cognition</subject><subject>Dose-Response Relationship, Drug</subject><subject>ethanol</subject><subject>Feeding. Feeding behavior</subject><subject>Free radicals</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Injections, Intraperitoneal</subject><subject>leaves</subject><subject>Male</subject><subject>Medical research</subject><subject>medicinal plants</subject><subject>memory</subject><subject>Memory - drug effects</subject><subject>Memory - physiology</subject><subject>Memory retention</subject><subject>mnemogenic effect</subject><subject>Muscarinic Agonists - metabolism</subject><subject>Muscarinic cholinoceptor</subject><subject>niacin</subject><subject>Nicotine</subject><subject>Nicotine - agonists</subject><subject>Nicotine - antagonists & inhibitors</subject><subject>Nicotine - metabolism</subject><subject>Nicotinic Agonists - metabolism</subject><subject>Nicotinic cholinoceptor</subject><subject>Pilocarpine - agonists</subject><subject>Pilocarpine - antagonists & inhibitors</subject><subject>Pilocarpine - metabolism</subject><subject>plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves - chemistry</subject><subject>Plant sciences</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Cholinergic - drug effects</subject><subject>Receptors, Cholinergic - metabolism</subject><subject>Retention</subject><subject>Rodents</subject><subject>Sage</subject><subject>Salvia officinalis</subject><subject>Salvia officinalis - chemistry</subject><subject>supercritical fluid extraction</subject><subject>Teacher education</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0899-9007</issn><issn>1873-1244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp90UuLFDEQB_BGFHdc_QBeNLC46KHbSj_TeJJlfcCAh3XPoTpdmcnQjzVJzzJ-emudgQUPnhLCrypJ_ZPktYRMgqw_7rJpiVkOUGVQZyDhSbKSqilSmZfl02QFqm3TFqA5S16EsAMA2dbt8-RM1hUXVWqV_L62lkwMYrbiBoe9Q95ZZ9yEgwtinYn3ATf0QQyEe2I2iZHG2R-Ep0hTdHyAUy8ct3BTJI_m79m9i1sRtyTMdh7cRH7jjAiHEGlkJzzG8DJ5ZnEI9Oq0nie3X65_Xn1L1z--fr_6vE5NWRQx7RUqo0D2hYHGdLlBQkUkLfTQKYKuswVUbY788dYUlFcdUtWXjZUN2a4uzpPLY987P_9aKEQ9umBoGHCieQm6buq2UAAML_6Bu3nxPIigpSx4jrLKFSt5VMbPIXiy-s67Ef1BS9APseid5lj0Qywaas2xcM2bU-elG6l_rDjlwODdCWAwOFiPk3Hh0TWqLau2ZPf26CzOGjeeze1NDrLgW5q8lBWLT0dBPNK9I6-DcTQZ6p3noHU_u_889A8KMLTv</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>Eidi, Maryam</creator><creator>Eidi, Akram</creator><creator>Bahar, Massih</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20060301</creationdate><title>Effects of Salvia officinalis L. (sage) leaves on memory retention and its interaction with the cholinergic system in rats</title><author>Eidi, Maryam ; Eidi, Akram ; Bahar, Massih</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-d8a8c801d3c07cb2caea8ee1f0d0b8e0bbf30592a8739c3e25bae5d47f17efb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Alzheimer's disease</topic><topic>Andorra</topic><topic>Animal cognition</topic><topic>Animals</topic><topic>antibacterial properties</topic><topic>antifungal properties</topic><topic>antiviral properties</topic><topic>astringency</topic><topic>Avoidance Learning - drug effects</topic><topic>Avoidance Learning - physiology</topic><topic>Biological and medical sciences</topic><topic>cholinergic agents</topic><topic>Cholinergic Antagonists - metabolism</topic><topic>cognition</topic><topic>Dose-Response Relationship, Drug</topic><topic>ethanol</topic><topic>Feeding. Feeding behavior</topic><topic>Free radicals</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Injections, Intraperitoneal</topic><topic>leaves</topic><topic>Male</topic><topic>Medical research</topic><topic>medicinal plants</topic><topic>memory</topic><topic>Memory - drug effects</topic><topic>Memory - physiology</topic><topic>Memory retention</topic><topic>mnemogenic effect</topic><topic>Muscarinic Agonists - metabolism</topic><topic>Muscarinic cholinoceptor</topic><topic>niacin</topic><topic>Nicotine</topic><topic>Nicotine - agonists</topic><topic>Nicotine - antagonists & inhibitors</topic><topic>Nicotine - metabolism</topic><topic>Nicotinic Agonists - metabolism</topic><topic>Nicotinic cholinoceptor</topic><topic>Pilocarpine - agonists</topic><topic>Pilocarpine - antagonists & inhibitors</topic><topic>Pilocarpine - metabolism</topic><topic>plant extracts</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Leaves - chemistry</topic><topic>Plant sciences</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Cholinergic - drug effects</topic><topic>Receptors, Cholinergic - metabolism</topic><topic>Retention</topic><topic>Rodents</topic><topic>Sage</topic><topic>Salvia officinalis</topic><topic>Salvia officinalis - chemistry</topic><topic>supercritical fluid extraction</topic><topic>Teacher education</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eidi, Maryam</creatorcontrib><creatorcontrib>Eidi, Akram</creatorcontrib><creatorcontrib>Bahar, Massih</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eidi, Maryam</au><au>Eidi, Akram</au><au>Bahar, Massih</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Salvia officinalis L. (sage) leaves on memory retention and its interaction with the cholinergic system in rats</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><addtitle>Nutrition</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>22</volume><issue>3</issue><spage>321</spage><epage>326</epage><pages>321-326</pages><issn>0899-9007</issn><eissn>1873-1244</eissn><coden>NUTRER</coden><abstract>The leaves of sage (
Salvia officinalis L., Lamiaceae) are reported to have a wide range of biological activities, such as anti-bacterial, fungistatic, virustatic, astringent, eupeptic and anti-hydrotic effects. To determine the mnemogenic effect of sage leaves, we investigated the effects of ethanolic extract of sage leaves and its interaction with cholinergic system on memory retention of passive avoidance learning in rats.
Post-training intracerebroventricular (i.c.v) injections were carried out in all the experiments except ethanolic extract (i.p. intraperitoneally).
Administration of ethanolic extract (50 mg/kg), pilocarpine (0.5 and 1 mg/rat), the muscarinic cholinoceptor agonist, and nicotine (0.1 and 1 μg/rat) increased, while mecamylamine (1, 5 μg/rat), the muscarinic cholinoceptor antagonist, and mecamylamine (0.01 and 0.1 μg/rat), the nicotine cholinoceptor antagonist decreased memory retention in rats. Activation of muscarinic cholinoceptors by pilocarpine potentiated the response of ethanolic extract. Also, pharmacological blockade of scopolamine attenuated potentiating effect of ethanolic extract. Activation of nicotinic cholinoceptor by nicotine potentiated the response of ethanolic extract. Blockade of nicotinic cholinoceptor by mecamylamine attenuated the response of ethanolic extract.
It is concluded that the ethanolic extract of salvia officinalis potentiated memory retention and also it has an interaction with muscarinic and nicotinic cholinergic systems that is involved in the memory retention process.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16500558</pmid><doi>10.1016/j.nut.2005.06.010</doi><tpages>6</tpages></addata></record> |
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| ispartof | Nutrition (Burbank, Los Angeles County, Calif.), 2006-03, Vol.22 (3), p.321-326 |
| issn | 0899-9007 1873-1244 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alzheimer's disease Andorra Animal cognition Animals antibacterial properties antifungal properties antiviral properties astringency Avoidance Learning - drug effects Avoidance Learning - physiology Biological and medical sciences cholinergic agents Cholinergic Antagonists - metabolism cognition Dose-Response Relationship, Drug ethanol Feeding. Feeding behavior Free radicals Fundamental and applied biological sciences. Psychology Injections, Intraperitoneal leaves Male Medical research medicinal plants memory Memory - drug effects Memory - physiology Memory retention mnemogenic effect Muscarinic Agonists - metabolism Muscarinic cholinoceptor niacin Nicotine Nicotine - agonists Nicotine - antagonists & inhibitors Nicotine - metabolism Nicotinic Agonists - metabolism Nicotinic cholinoceptor Pilocarpine - agonists Pilocarpine - antagonists & inhibitors Pilocarpine - metabolism plant extracts Plant Extracts - pharmacology Plant Leaves - chemistry Plant sciences Rat Rats Rats, Wistar Receptors, Cholinergic - drug effects Receptors, Cholinergic - metabolism Retention Rodents Sage Salvia officinalis Salvia officinalis - chemistry supercritical fluid extraction Teacher education Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Effects of Salvia officinalis L. (sage) leaves on memory retention and its interaction with the cholinergic system in rats |
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