CD40L proinflammatory and profibrotic effects on proximal tubular epithelial cells: role of NF-kappaB and lyn

Chronic allograft nephropathy (CAN) is the main cause of renal graft loss, but its pathogenic mechanisms are still unclear. Immune system activation has been suggested as a key event in the development of CAN. CD40 is a co-stimulatory protein whose expression is upregulated in proximal tubular epith...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2006-03, Vol.17 (3), p.627-636
Hauptverfasser:	Pontrelli, Paola, Ursi, Michele, Ranieri, Elena, Capobianco, Carmen, Schena, Francesco P, Gesualdo, Loreto, Grandaliano, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Blotting, Northern Blotting, Western CD40 Ligand - drug effects CD40 Ligand - metabolism Cells, Cultured Humans Immunoprecipitation Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - metabolism Microscopy, Confocal NF-kappa B - metabolism Plasminogen Activator Inhibitor 1 - pharmacology Probability Reverse Transcriptase Polymerase Chain Reaction Sensitivity and Specificity Signal Transduction src-Family Kinases - metabolism
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