Large congenital melanocytic nevi and neurocutaneous melanocytosis: One pediatric center's experience
Background Large congenital melanocytic nevi (LCMN) predispose to neurocutaneous melanocytosis (NCM), which is associated with significant morbidity and mortality. Objective To identify risk factors for NCM in patients with LCMN and suggest guidelines for their management. Methods Medical records of...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 2009-11, Vol.61 (5), p.766-774 |
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| creator | Lovett, Audrey, MD, FRCPC Maari, Catherine, MD, FRCPC Decarie, Jean-Claude, MD, FRCPC Marcoux, Danielle, MD, FRCPC McCuaig, Catherine, MD, FRCPC Hatami, Afshin, MD, FRCPC Savard, Pascal, MD, FRCPC Powell, Julie, MD, FRCPC |
| description | Background Large congenital melanocytic nevi (LCMN) predispose to neurocutaneous melanocytosis (NCM), which is associated with significant morbidity and mortality. Objective To identify risk factors for NCM in patients with LCMN and suggest guidelines for their management. Methods Medical records of patients with LCMN were reviewed at Sainte-Justine Hospital between 1980 and 2006. Presence of multiple satellite nevi and posterior midline location were evaluated as risk factors for NCM using chi-square test. Magnetic resonance imaging scans were reviewed by a neuroradiologist. Results Twenty-six of 52 patients underwent radiologic investigation. Six of 26 (23%) had NCM. Patients with this condition are more likely to have multiple satellite nevi (100% vs 50%, P = .03) and have a trend to posterior midline location of their LCMN (100% vs 60%, P = .08). Patients with NCM are more likely to have both multiple satellite nevi and posterior midline location (100% vs 25%, P = .002). Radiologic findings are also presented. Limitations This was a retrospective case series with imprecise chart data in 38% of cases. Conclusion The presence of multiple satellite nevi alone or with associated posterior midline location of LCMN is associated with a higher risk of NCM. We recommend magnetic resonance imaging testing before 4 months of age in patients with these features. |
| doi_str_mv | 10.1016/j.jaad.2008.11.022 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67693393</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0190962208014540</els_id><sourcerecordid>67693393</sourcerecordid><originalsourceid>FETCH-LOGICAL-c439t-4cf7723118da9dc8e1e1b1c565dda927e680bca340ee312c855bdc4ed0a44af63</originalsourceid><addsrcrecordid>eNp9kk2LFDEQhoMo7uzoH_AgfdE99Vj56HS3LIIsfsHAHtRzyFSql7Q96THpXpx_b9oZXPAgBBLC81YVD8XYCw4bDly_6Te9tW4jAJoN5xsQ4hFbcWjrUtdN_ZitgLdQtlqIC3aZUg8ArZL1U3bB21prqZoVo62Nd1TgGO4o-MkOxZ4GG0Y8Th6LQPe-sMHlxxxHnCcbaJzTAzMmn94Wt4GKAzlvp5hDSGGieJUK-nWg6CkgPWNPOjsken6-1-z7xw_fbj6X29tPX27eb0tUsp1KhV1dC8l542zrsCFOfMex0pXLH6Im3cAOrVRAJLnApqp2DhU5sErZTss1e32qe4jjz5nSZPY-IQ3DaW6ja91Kmc-aiROIcUwpUmcO0e9tPBoOZpFrerPINYtcw7nJcnPo5bn6vNuTe4icbWbg1RmwCe3QRRvQp7-cEFDVrVaZuz5xlF3ce4om4R9PzkfCybjR_3-Od__EcfDB544_6EipH-cYsmXDTRIGzNdlDZYtgAa4qhTI34iBrvM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67693393</pqid></control><display><type>article</type><title>Large congenital melanocytic nevi and neurocutaneous melanocytosis: One pediatric center's experience</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Lovett, Audrey, MD, FRCPC ; Maari, Catherine, MD, FRCPC ; Decarie, Jean-Claude, MD, FRCPC ; Marcoux, Danielle, MD, FRCPC ; McCuaig, Catherine, MD, FRCPC ; Hatami, Afshin, MD, FRCPC ; Savard, Pascal, MD, FRCPC ; Powell, Julie, MD, FRCPC</creator><creatorcontrib>Lovett, Audrey, MD, FRCPC ; Maari, Catherine, MD, FRCPC ; Decarie, Jean-Claude, MD, FRCPC ; Marcoux, Danielle, MD, FRCPC ; McCuaig, Catherine, MD, FRCPC ; Hatami, Afshin, MD, FRCPC ; Savard, Pascal, MD, FRCPC ; Powell, Julie, MD, FRCPC</creatorcontrib><description>Background Large congenital melanocytic nevi (LCMN) predispose to neurocutaneous melanocytosis (NCM), which is associated with significant morbidity and mortality. Objective To identify risk factors for NCM in patients with LCMN and suggest guidelines for their management. Methods Medical records of patients with LCMN were reviewed at Sainte-Justine Hospital between 1980 and 2006. Presence of multiple satellite nevi and posterior midline location were evaluated as risk factors for NCM using chi-square test. Magnetic resonance imaging scans were reviewed by a neuroradiologist. Results Twenty-six of 52 patients underwent radiologic investigation. Six of 26 (23%) had NCM. Patients with this condition are more likely to have multiple satellite nevi (100% vs 50%, P = .03) and have a trend to posterior midline location of their LCMN (100% vs 60%, P = .08). Patients with NCM are more likely to have both multiple satellite nevi and posterior midline location (100% vs 25%, P = .002). Radiologic findings are also presented. Limitations This was a retrospective case series with imprecise chart data in 38% of cases. Conclusion The presence of multiple satellite nevi alone or with associated posterior midline location of LCMN is associated with a higher risk of NCM. We recommend magnetic resonance imaging testing before 4 months of age in patients with these features.</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/j.jaad.2008.11.022</identifier><identifier>PMID: 19766348</identifier><identifier>CODEN: JAADDB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Biological and medical sciences ; Child ; Child, Preschool ; Dermatology ; Female ; Follow-Up Studies ; General aspects ; Humans ; Infant ; Infant, Newborn ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Melanosis - congenital ; Melanosis - mortality ; Melanosis - pathology ; Neurocutaneous Syndromes - congenital ; Neurocutaneous Syndromes - mortality ; Neurocutaneous Syndromes - pathology ; Nevus, Pigmented - congenital ; Nevus, Pigmented - mortality ; Nevus, Pigmented - pathology ; Pigmentary diseases of the skin ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Risk Factors ; Skin Neoplasms - congenital ; Skin Neoplasms - mortality ; Skin Neoplasms - pathology ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Journal of the American Academy of Dermatology, 2009-11, Vol.61 (5), p.766-774</ispartof><rights>American Academy of Dermatology, Inc.</rights><rights>2008 American Academy of Dermatology, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-4cf7723118da9dc8e1e1b1c565dda927e680bca340ee312c855bdc4ed0a44af63</citedby><cites>FETCH-LOGICAL-c439t-4cf7723118da9dc8e1e1b1c565dda927e680bca340ee312c855bdc4ed0a44af63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaad.2008.11.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22057964$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19766348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lovett, Audrey, MD, FRCPC</creatorcontrib><creatorcontrib>Maari, Catherine, MD, FRCPC</creatorcontrib><creatorcontrib>Decarie, Jean-Claude, MD, FRCPC</creatorcontrib><creatorcontrib>Marcoux, Danielle, MD, FRCPC</creatorcontrib><creatorcontrib>McCuaig, Catherine, MD, FRCPC</creatorcontrib><creatorcontrib>Hatami, Afshin, MD, FRCPC</creatorcontrib><creatorcontrib>Savard, Pascal, MD, FRCPC</creatorcontrib><creatorcontrib>Powell, Julie, MD, FRCPC</creatorcontrib><title>Large congenital melanocytic nevi and neurocutaneous melanocytosis: One pediatric center's experience</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>Background Large congenital melanocytic nevi (LCMN) predispose to neurocutaneous melanocytosis (NCM), which is associated with significant morbidity and mortality. Objective To identify risk factors for NCM in patients with LCMN and suggest guidelines for their management. Methods Medical records of patients with LCMN were reviewed at Sainte-Justine Hospital between 1980 and 2006. Presence of multiple satellite nevi and posterior midline location were evaluated as risk factors for NCM using chi-square test. Magnetic resonance imaging scans were reviewed by a neuroradiologist. Results Twenty-six of 52 patients underwent radiologic investigation. Six of 26 (23%) had NCM. Patients with this condition are more likely to have multiple satellite nevi (100% vs 50%, P = .03) and have a trend to posterior midline location of their LCMN (100% vs 60%, P = .08). Patients with NCM are more likely to have both multiple satellite nevi and posterior midline location (100% vs 25%, P = .002). Radiologic findings are also presented. Limitations This was a retrospective case series with imprecise chart data in 38% of cases. Conclusion The presence of multiple satellite nevi alone or with associated posterior midline location of LCMN is associated with a higher risk of NCM. We recommend magnetic resonance imaging testing before 4 months of age in patients with these features.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dermatology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melanosis - congenital</subject><subject>Melanosis - mortality</subject><subject>Melanosis - pathology</subject><subject>Neurocutaneous Syndromes - congenital</subject><subject>Neurocutaneous Syndromes - mortality</subject><subject>Neurocutaneous Syndromes - pathology</subject><subject>Nevus, Pigmented - congenital</subject><subject>Nevus, Pigmented - mortality</subject><subject>Nevus, Pigmented - pathology</subject><subject>Pigmentary diseases of the skin</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Skin Neoplasms - congenital</subject><subject>Skin Neoplasms - mortality</subject><subject>Skin Neoplasms - pathology</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk2LFDEQhoMo7uzoH_AgfdE99Vj56HS3LIIsfsHAHtRzyFSql7Q96THpXpx_b9oZXPAgBBLC81YVD8XYCw4bDly_6Te9tW4jAJoN5xsQ4hFbcWjrUtdN_ZitgLdQtlqIC3aZUg8ArZL1U3bB21prqZoVo62Nd1TgGO4o-MkOxZ4GG0Y8Th6LQPe-sMHlxxxHnCcbaJzTAzMmn94Wt4GKAzlvp5hDSGGieJUK-nWg6CkgPWNPOjsken6-1-z7xw_fbj6X29tPX27eb0tUsp1KhV1dC8l542zrsCFOfMex0pXLH6Im3cAOrVRAJLnApqp2DhU5sErZTss1e32qe4jjz5nSZPY-IQ3DaW6ja91Kmc-aiROIcUwpUmcO0e9tPBoOZpFrerPINYtcw7nJcnPo5bn6vNuTe4icbWbg1RmwCe3QRRvQp7-cEFDVrVaZuz5xlF3ce4om4R9PzkfCybjR_3-Od__EcfDB544_6EipH-cYsmXDTRIGzNdlDZYtgAa4qhTI34iBrvM</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Lovett, Audrey, MD, FRCPC</creator><creator>Maari, Catherine, MD, FRCPC</creator><creator>Decarie, Jean-Claude, MD, FRCPC</creator><creator>Marcoux, Danielle, MD, FRCPC</creator><creator>McCuaig, Catherine, MD, FRCPC</creator><creator>Hatami, Afshin, MD, FRCPC</creator><creator>Savard, Pascal, MD, FRCPC</creator><creator>Powell, Julie, MD, FRCPC</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>Large congenital melanocytic nevi and neurocutaneous melanocytosis: One pediatric center's experience</title><author>Lovett, Audrey, MD, FRCPC ; Maari, Catherine, MD, FRCPC ; Decarie, Jean-Claude, MD, FRCPC ; Marcoux, Danielle, MD, FRCPC ; McCuaig, Catherine, MD, FRCPC ; Hatami, Afshin, MD, FRCPC ; Savard, Pascal, MD, FRCPC ; Powell, Julie, MD, FRCPC</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-4cf7723118da9dc8e1e1b1c565dda927e680bca340ee312c855bdc4ed0a44af63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dermatology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melanosis - congenital</topic><topic>Melanosis - mortality</topic><topic>Melanosis - pathology</topic><topic>Neurocutaneous Syndromes - congenital</topic><topic>Neurocutaneous Syndromes - mortality</topic><topic>Neurocutaneous Syndromes - pathology</topic><topic>Nevus, Pigmented - congenital</topic><topic>Nevus, Pigmented - mortality</topic><topic>Nevus, Pigmented - pathology</topic><topic>Pigmentary diseases of the skin</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Skin Neoplasms - congenital</topic><topic>Skin Neoplasms - mortality</topic><topic>Skin Neoplasms - pathology</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lovett, Audrey, MD, FRCPC</creatorcontrib><creatorcontrib>Maari, Catherine, MD, FRCPC</creatorcontrib><creatorcontrib>Decarie, Jean-Claude, MD, FRCPC</creatorcontrib><creatorcontrib>Marcoux, Danielle, MD, FRCPC</creatorcontrib><creatorcontrib>McCuaig, Catherine, MD, FRCPC</creatorcontrib><creatorcontrib>Hatami, Afshin, MD, FRCPC</creatorcontrib><creatorcontrib>Savard, Pascal, MD, FRCPC</creatorcontrib><creatorcontrib>Powell, Julie, MD, FRCPC</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lovett, Audrey, MD, FRCPC</au><au>Maari, Catherine, MD, FRCPC</au><au>Decarie, Jean-Claude, MD, FRCPC</au><au>Marcoux, Danielle, MD, FRCPC</au><au>McCuaig, Catherine, MD, FRCPC</au><au>Hatami, Afshin, MD, FRCPC</au><au>Savard, Pascal, MD, FRCPC</au><au>Powell, Julie, MD, FRCPC</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Large congenital melanocytic nevi and neurocutaneous melanocytosis: One pediatric center's experience</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>61</volume><issue>5</issue><spage>766</spage><epage>774</epage><pages>766-774</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><coden>JAADDB</coden><abstract>Background Large congenital melanocytic nevi (LCMN) predispose to neurocutaneous melanocytosis (NCM), which is associated with significant morbidity and mortality. Objective To identify risk factors for NCM in patients with LCMN and suggest guidelines for their management. Methods Medical records of patients with LCMN were reviewed at Sainte-Justine Hospital between 1980 and 2006. Presence of multiple satellite nevi and posterior midline location were evaluated as risk factors for NCM using chi-square test. Magnetic resonance imaging scans were reviewed by a neuroradiologist. Results Twenty-six of 52 patients underwent radiologic investigation. Six of 26 (23%) had NCM. Patients with this condition are more likely to have multiple satellite nevi (100% vs 50%, P = .03) and have a trend to posterior midline location of their LCMN (100% vs 60%, P = .08). Patients with NCM are more likely to have both multiple satellite nevi and posterior midline location (100% vs 25%, P = .002). Radiologic findings are also presented. Limitations This was a retrospective case series with imprecise chart data in 38% of cases. Conclusion The presence of multiple satellite nevi alone or with associated posterior midline location of LCMN is associated with a higher risk of NCM. We recommend magnetic resonance imaging testing before 4 months of age in patients with these features.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>19766348</pmid><doi>10.1016/j.jaad.2008.11.022</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Biological and medical sciences Child Child, Preschool Dermatology Female Follow-Up Studies General aspects Humans Infant Infant, Newborn Magnetic Resonance Imaging Male Medical sciences Melanosis - congenital Melanosis - mortality Melanosis - pathology Neurocutaneous Syndromes - congenital Neurocutaneous Syndromes - mortality Neurocutaneous Syndromes - pathology Nevus, Pigmented - congenital Nevus, Pigmented - mortality Nevus, Pigmented - pathology Pigmentary diseases of the skin Predictive Value of Tests Prognosis Retrospective Studies Risk Factors Skin Neoplasms - congenital Skin Neoplasms - mortality Skin Neoplasms - pathology Tumors of the skin and soft tissue. Premalignant lesions |
| title | Large congenital melanocytic nevi and neurocutaneous melanocytosis: One pediatric center's experience |
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