Left Ventricular Dysfunction and Remodeling in Streptozotocin-Induced Diabetic Rats

Background It is not fully clarified how diabetes mellitus (DM)-induced cardiac dysfunction is associated with histopathological changes of the heart in a long lasting period of DM. Methods and Results Eighteen weeks after a streptozotocin injection was given to Wistar - Kyoto rats (D rats), echocar...

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Veröffentlicht in:	Circulation Journal 2006, Vol.70(3), pp.327-334
Hauptverfasser:	Nemoto, Osamu, Kawaguchi, Michiko, Yaoita, Hiroyuki, Miyake, Katsuya, Maehara, Kazuhira, Maruyama, Yukio
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - ultrastructure Actin filament Adrenergic beta-Agonists - pharmacology Animals Cardiomyocyte Coronary Vessels - pathology Coronary Vessels - physiopathology Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - physiopathology Diabetic cardiomyopathy Dobutamine - pharmacology Echocardiography Heart Ventricles - drug effects Heart Ventricles - pathology Heart Ventricles - physiopathology Heart Ventricles - ultrastructure Hemodynamics - drug effects Hemodynamics - physiology Histocytochemistry Left ventricular systolic dysfunction Male Microscopy, Electron Microscopy, Fluorescence Myocytes, Cardiac - pathology Myocytes, Cardiac - ultrastructure Rats Rats, Inbred WKY Streptozotocin-induced diabetic rats Ventricular Dysfunction, Left - pathology Ventricular Dysfunction, Left - physiopathology Ventricular Remodeling - physiology
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