Association of White Matter Lesions and Lacunar Infarcts With Executive Functioning: The SMART-MR Study
The authors investigated the association of white matter lesions and lacunar infarcts with cognitive performance and whether brain atrophy mediates these associations. Within the Second Manifestations of Arterial Disease-Magnetic Resonance study (2001-2005, the Netherlands), cross-sectional analyses...
Gespeichert in:
| Veröffentlicht in: | American journal of epidemiology 2009-11, Vol.170 (9), p.1147-1155 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1155 |
|---|---|
| container_issue | 9 |
| container_start_page | 1147 |
| container_title | American journal of epidemiology |
| container_volume | 170 |
| creator | GEERLINGS, Mirjam I APPELMAN, Auke P. A VINCKEN, Koen L MALI, Willem P. T. M VAN DER GRAAF, Yolanda |
| description | The authors investigated the association of white matter lesions and lacunar infarcts with cognitive performance and whether brain atrophy mediates these associations. Within the Second Manifestations of Arterial Disease-Magnetic Resonance study (2001-2005, the Netherlands), cross-sectional analyses of 522 patients were performed (mean age, 57 years (standard deviation, 10); 76% male). Brain segmentation was used to quantify volumes of brain tissue, cerebrospinal fluid, and white matter lesions. Infarcts were rated visually. Brain volume, ventricular volume, and gray matter volume were divided by intracranial volume to obtain indicators of brain atrophy. Neuropsychological tests assessing executive functioning and memory were performed, and scores were transformed into z scores. The authors used linear regression analyses, adjusted for age, sex, education, intelligence, and vascular risk factors, to investigate the association of white matter lesions and number of lacunar infarcts with cognitive performance. A 1-standard-deviation higher volume of white matter lesions (beta = -0.12, 95% confidence interval: -0.20, -0.04) and the presence of >or=2 lacunar infarcts (beta = -0.48, 95% confidence interval: -0.87, -0.09) were associated with worse executive functioning. These associations remained after adjusting for brain atrophy. Both were not associated with worse memory. Results suggest that subcortical ischemic vascular lesions are associated with decreased executive functioning, but not with memory functioning, independent of brain atrophy. |
| doi_str_mv | 10.1093/aje/kwp256 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67690579</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67690579</sourcerecordid><originalsourceid>FETCH-LOGICAL-c308t-c0c87820e09fe49011a3cafeb3cee607abaa3cb859ba38d505d08ae8c1d9f1713</originalsourceid><addsrcrecordid>eNpd0MFqGzEQBmBRGho3zaUPUEQhPRS2Ge1aK6k3E5I2YFNIHHJcZrWzsVxb60ratHn7Ktik0NMMw8fP8DP2XsAXAaY6xzWd__y9K2X9ik3EVNVFnffXbAIAZWHKujxmb2NcAwhhJLxhx8IoXUk9nbCHWYyDdZjc4PnQ8_uVS8QXmBIFPqeYz5Gj7_gc7egx8GvfY7Ap8nuXVvzyD9kxuUfiV6O3zyHOP3zlyxXx28XsZlksbvhtGrund-yox02k08M8YXdXl8uL78X8x7fri9m8sBXoVFiwWukSCExPU5MfxspiT21liWpQ2GI-tFqaFivdSZAdaCRtRWd6oUR1wj7tc3dh-DVSTM3WRUubDXoaxtjUqjYglcnw439wPYzB59-aspJGiKlWGX3eIxuGGAP1zS64LYanRkDz3H2Tu2_23Wf84ZA4tlvq_tFD2RmcHQBGi5s-oLcuvriyBGm0UtVf2pSNKQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>235911487</pqid></control><display><type>article</type><title>Association of White Matter Lesions and Lacunar Infarcts With Executive Functioning: The SMART-MR Study</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>GEERLINGS, Mirjam I ; APPELMAN, Auke P. A ; VINCKEN, Koen L ; MALI, Willem P. T. M ; VAN DER GRAAF, Yolanda</creator><creatorcontrib>GEERLINGS, Mirjam I ; APPELMAN, Auke P. A ; VINCKEN, Koen L ; MALI, Willem P. T. M ; VAN DER GRAAF, Yolanda ; SMART Study Group ; Yolanda van der Graaf for the SMART Study Group</creatorcontrib><description>The authors investigated the association of white matter lesions and lacunar infarcts with cognitive performance and whether brain atrophy mediates these associations. Within the Second Manifestations of Arterial Disease-Magnetic Resonance study (2001-2005, the Netherlands), cross-sectional analyses of 522 patients were performed (mean age, 57 years (standard deviation, 10); 76% male). Brain segmentation was used to quantify volumes of brain tissue, cerebrospinal fluid, and white matter lesions. Infarcts were rated visually. Brain volume, ventricular volume, and gray matter volume were divided by intracranial volume to obtain indicators of brain atrophy. Neuropsychological tests assessing executive functioning and memory were performed, and scores were transformed into z scores. The authors used linear regression analyses, adjusted for age, sex, education, intelligence, and vascular risk factors, to investigate the association of white matter lesions and number of lacunar infarcts with cognitive performance. A 1-standard-deviation higher volume of white matter lesions (beta = -0.12, 95% confidence interval: -0.20, -0.04) and the presence of >or=2 lacunar infarcts (beta = -0.48, 95% confidence interval: -0.87, -0.09) were associated with worse executive functioning. These associations remained after adjusting for brain atrophy. Both were not associated with worse memory. Results suggest that subcortical ischemic vascular lesions are associated with decreased executive functioning, but not with memory functioning, independent of brain atrophy.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/aje/kwp256</identifier><identifier>PMID: 19783584</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Aged ; Analysis. Health state ; Atrophy ; Biological and medical sciences ; Brain - pathology ; Brain diseases ; Brain Infarction - cerebrospinal fluid ; Brain Infarction - complications ; Brain Infarction - pathology ; Cognition & reasoning ; Cognition Disorders - cerebrospinal fluid ; Cognition Disorders - etiology ; Cognition Disorders - pathology ; Cross-Sectional Studies ; Epidemiology ; Female ; General aspects ; Humans ; Injuries ; Linear Models ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Memory ; Middle Aged ; Neurology ; Neuropsychological Tests ; NMR ; Nuclear magnetic resonance ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors</subject><ispartof>American journal of epidemiology, 2009-11, Vol.170 (9), p.1147-1155</ispartof><rights>2009 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Nov 1, 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c308t-c0c87820e09fe49011a3cafeb3cee607abaa3cb859ba38d505d08ae8c1d9f1713</citedby><cites>FETCH-LOGICAL-c308t-c0c87820e09fe49011a3cafeb3cee607abaa3cb859ba38d505d08ae8c1d9f1713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22059877$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19783584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GEERLINGS, Mirjam I</creatorcontrib><creatorcontrib>APPELMAN, Auke P. A</creatorcontrib><creatorcontrib>VINCKEN, Koen L</creatorcontrib><creatorcontrib>MALI, Willem P. T. M</creatorcontrib><creatorcontrib>VAN DER GRAAF, Yolanda</creatorcontrib><creatorcontrib>SMART Study Group</creatorcontrib><creatorcontrib>Yolanda van der Graaf for the SMART Study Group</creatorcontrib><title>Association of White Matter Lesions and Lacunar Infarcts With Executive Functioning: The SMART-MR Study</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>The authors investigated the association of white matter lesions and lacunar infarcts with cognitive performance and whether brain atrophy mediates these associations. Within the Second Manifestations of Arterial Disease-Magnetic Resonance study (2001-2005, the Netherlands), cross-sectional analyses of 522 patients were performed (mean age, 57 years (standard deviation, 10); 76% male). Brain segmentation was used to quantify volumes of brain tissue, cerebrospinal fluid, and white matter lesions. Infarcts were rated visually. Brain volume, ventricular volume, and gray matter volume were divided by intracranial volume to obtain indicators of brain atrophy. Neuropsychological tests assessing executive functioning and memory were performed, and scores were transformed into z scores. The authors used linear regression analyses, adjusted for age, sex, education, intelligence, and vascular risk factors, to investigate the association of white matter lesions and number of lacunar infarcts with cognitive performance. A 1-standard-deviation higher volume of white matter lesions (beta = -0.12, 95% confidence interval: -0.20, -0.04) and the presence of >or=2 lacunar infarcts (beta = -0.48, 95% confidence interval: -0.87, -0.09) were associated with worse executive functioning. These associations remained after adjusting for brain atrophy. Both were not associated with worse memory. Results suggest that subcortical ischemic vascular lesions are associated with decreased executive functioning, but not with memory functioning, independent of brain atrophy.</description><subject>Aged</subject><subject>Analysis. Health state</subject><subject>Atrophy</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Brain diseases</subject><subject>Brain Infarction - cerebrospinal fluid</subject><subject>Brain Infarction - complications</subject><subject>Brain Infarction - pathology</subject><subject>Cognition & reasoning</subject><subject>Cognition Disorders - cerebrospinal fluid</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - pathology</subject><subject>Cross-Sectional Studies</subject><subject>Epidemiology</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Injuries</subject><subject>Linear Models</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Prospective Studies</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Factors</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0MFqGzEQBmBRGho3zaUPUEQhPRS2Ge1aK6k3E5I2YFNIHHJcZrWzsVxb60ratHn7Ktik0NMMw8fP8DP2XsAXAaY6xzWd__y9K2X9ik3EVNVFnffXbAIAZWHKujxmb2NcAwhhJLxhx8IoXUk9nbCHWYyDdZjc4PnQ8_uVS8QXmBIFPqeYz5Gj7_gc7egx8GvfY7Ap8nuXVvzyD9kxuUfiV6O3zyHOP3zlyxXx28XsZlksbvhtGrund-yox02k08M8YXdXl8uL78X8x7fri9m8sBXoVFiwWukSCExPU5MfxspiT21liWpQ2GI-tFqaFivdSZAdaCRtRWd6oUR1wj7tc3dh-DVSTM3WRUubDXoaxtjUqjYglcnw439wPYzB59-aspJGiKlWGX3eIxuGGAP1zS64LYanRkDz3H2Tu2_23Wf84ZA4tlvq_tFD2RmcHQBGi5s-oLcuvriyBGm0UtVf2pSNKQ</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>GEERLINGS, Mirjam I</creator><creator>APPELMAN, Auke P. A</creator><creator>VINCKEN, Koen L</creator><creator>MALI, Willem P. T. M</creator><creator>VAN DER GRAAF, Yolanda</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>Association of White Matter Lesions and Lacunar Infarcts With Executive Functioning: The SMART-MR Study</title><author>GEERLINGS, Mirjam I ; APPELMAN, Auke P. A ; VINCKEN, Koen L ; MALI, Willem P. T. M ; VAN DER GRAAF, Yolanda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c308t-c0c87820e09fe49011a3cafeb3cee607abaa3cb859ba38d505d08ae8c1d9f1713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Analysis. Health state</topic><topic>Atrophy</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Brain diseases</topic><topic>Brain Infarction - cerebrospinal fluid</topic><topic>Brain Infarction - complications</topic><topic>Brain Infarction - pathology</topic><topic>Cognition & reasoning</topic><topic>Cognition Disorders - cerebrospinal fluid</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - pathology</topic><topic>Cross-Sectional Studies</topic><topic>Epidemiology</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Injuries</topic><topic>Linear Models</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Prospective Studies</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GEERLINGS, Mirjam I</creatorcontrib><creatorcontrib>APPELMAN, Auke P. A</creatorcontrib><creatorcontrib>VINCKEN, Koen L</creatorcontrib><creatorcontrib>MALI, Willem P. T. M</creatorcontrib><creatorcontrib>VAN DER GRAAF, Yolanda</creatorcontrib><creatorcontrib>SMART Study Group</creatorcontrib><creatorcontrib>Yolanda van der Graaf for the SMART Study Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GEERLINGS, Mirjam I</au><au>APPELMAN, Auke P. A</au><au>VINCKEN, Koen L</au><au>MALI, Willem P. T. M</au><au>VAN DER GRAAF, Yolanda</au><aucorp>SMART Study Group</aucorp><aucorp>Yolanda van der Graaf for the SMART Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of White Matter Lesions and Lacunar Infarcts With Executive Functioning: The SMART-MR Study</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am J Epidemiol</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>170</volume><issue>9</issue><spage>1147</spage><epage>1155</epage><pages>1147-1155</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><abstract>The authors investigated the association of white matter lesions and lacunar infarcts with cognitive performance and whether brain atrophy mediates these associations. Within the Second Manifestations of Arterial Disease-Magnetic Resonance study (2001-2005, the Netherlands), cross-sectional analyses of 522 patients were performed (mean age, 57 years (standard deviation, 10); 76% male). Brain segmentation was used to quantify volumes of brain tissue, cerebrospinal fluid, and white matter lesions. Infarcts were rated visually. Brain volume, ventricular volume, and gray matter volume were divided by intracranial volume to obtain indicators of brain atrophy. Neuropsychological tests assessing executive functioning and memory were performed, and scores were transformed into z scores. The authors used linear regression analyses, adjusted for age, sex, education, intelligence, and vascular risk factors, to investigate the association of white matter lesions and number of lacunar infarcts with cognitive performance. A 1-standard-deviation higher volume of white matter lesions (beta = -0.12, 95% confidence interval: -0.20, -0.04) and the presence of >or=2 lacunar infarcts (beta = -0.48, 95% confidence interval: -0.87, -0.09) were associated with worse executive functioning. These associations remained after adjusting for brain atrophy. Both were not associated with worse memory. Results suggest that subcortical ischemic vascular lesions are associated with decreased executive functioning, but not with memory functioning, independent of brain atrophy.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>19783584</pmid><doi>10.1093/aje/kwp256</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9262 |
| ispartof | American journal of epidemiology, 2009-11, Vol.170 (9), p.1147-1155 |
| issn | 0002-9262 1476-6256 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67690579 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Aged Analysis. Health state Atrophy Biological and medical sciences Brain - pathology Brain diseases Brain Infarction - cerebrospinal fluid Brain Infarction - complications Brain Infarction - pathology Cognition & reasoning Cognition Disorders - cerebrospinal fluid Cognition Disorders - etiology Cognition Disorders - pathology Cross-Sectional Studies Epidemiology Female General aspects Humans Injuries Linear Models Magnetic Resonance Imaging Male Medical sciences Memory Middle Aged Neurology Neuropsychological Tests NMR Nuclear magnetic resonance Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors |
| title | Association of White Matter Lesions and Lacunar Infarcts With Executive Functioning: The SMART-MR Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T15%3A56%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20White%20Matter%20Lesions%20and%20Lacunar%20Infarcts%20With%20Executive%20Functioning:%20The%20SMART-MR%20Study&rft.jtitle=American%20journal%20of%20epidemiology&rft.au=GEERLINGS,%20Mirjam%20I&rft.aucorp=SMART%20Study%20Group&rft.date=2009-11-01&rft.volume=170&rft.issue=9&rft.spage=1147&rft.epage=1155&rft.pages=1147-1155&rft.issn=0002-9262&rft.eissn=1476-6256&rft.coden=AJEPAS&rft_id=info:doi/10.1093/aje/kwp256&rft_dat=%3Cproquest_cross%3E67690579%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=235911487&rft_id=info:pmid/19783584&rfr_iscdi=true |