Arginine inhibits Na+-driven flagellar motors of alkaliphilic Bacillus
Abstract L-arginine has attracted a great deal of attention as an agent for refolding denatured proteins, and the mildness of its effects offer hope for a wide range of potential applications for this substance, including medicines with few side effects. We report that both l- and d-arginine inhibit...
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| Veröffentlicht in: | FEMS microbiology letters 2006-03, Vol.256 (2), p.224-228 |
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| container_title | FEMS microbiology letters |
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| creator | Atsumi, Tatsuo Yoshimura, Fuminobu Sugiyama, Shigeru |
| description | Abstract
L-arginine has attracted a great deal of attention as an agent for refolding denatured proteins, and the mildness of its effects offer hope for a wide range of potential applications for this substance, including medicines with few side effects. We report that both l- and d-arginine inhibits Na+-driven flagellar motors of alkaliphilic Bacillus by competing with Na+, which we take as evidence that arginine specifically binds to a molecular target. |
| doi_str_mv | 10.1111/j.1574-6968.2006.00117.x |
| format | Article |
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L-arginine has attracted a great deal of attention as an agent for refolding denatured proteins, and the mildness of its effects offer hope for a wide range of potential applications for this substance, including medicines with few side effects. We report that both l- and d-arginine inhibits Na+-driven flagellar motors of alkaliphilic Bacillus by competing with Na+, which we take as evidence that arginine specifically binds to a molecular target.</description><identifier>ISSN: 0378-1097</identifier><identifier>EISSN: 1574-6968</identifier><identifier>DOI: 10.1111/j.1574-6968.2006.00117.x</identifier><identifier>PMID: 16499610</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>alkaliphilic Bacillus ; amiloride ; Arginine ; Arginine - pharmacology ; Bacillus ; Bacillus - drug effects ; Bacillus - physiology ; Flagella ; Flagella - drug effects ; Microbiology ; Molecular Motor Proteins - drug effects ; Motors ; Movement - drug effects ; Na+‐driven flagellar motors ; Side effects</subject><ispartof>FEMS microbiology letters, 2006-03, Vol.256 (2), p.224-228</ispartof><rights>2006 Federation of European Microbiological Societies 2006</rights><rights>2006 Federation of European Microbiological Societies</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1574-6968.2006.00117.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1574-6968.2006.00117.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16499610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Atsumi, Tatsuo</creatorcontrib><creatorcontrib>Yoshimura, Fuminobu</creatorcontrib><creatorcontrib>Sugiyama, Shigeru</creatorcontrib><title>Arginine inhibits Na+-driven flagellar motors of alkaliphilic Bacillus</title><title>FEMS microbiology letters</title><addtitle>FEMS Microbiol Lett</addtitle><description>Abstract
L-arginine has attracted a great deal of attention as an agent for refolding denatured proteins, and the mildness of its effects offer hope for a wide range of potential applications for this substance, including medicines with few side effects. We report that both l- and d-arginine inhibits Na+-driven flagellar motors of alkaliphilic Bacillus by competing with Na+, which we take as evidence that arginine specifically binds to a molecular target.</description><subject>alkaliphilic Bacillus</subject><subject>amiloride</subject><subject>Arginine</subject><subject>Arginine - pharmacology</subject><subject>Bacillus</subject><subject>Bacillus - drug effects</subject><subject>Bacillus - physiology</subject><subject>Flagella</subject><subject>Flagella - drug effects</subject><subject>Microbiology</subject><subject>Molecular Motor Proteins - drug effects</subject><subject>Motors</subject><subject>Movement - drug effects</subject><subject>Na+‐driven flagellar motors</subject><subject>Side effects</subject><issn>0378-1097</issn><issn>1574-6968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kV1LwzAUhoMobk7_ghQEb6T15KNJC97ocCpMvdl9SNt0S03b2ay6_XtbNxUUc5PAeZ5weF-EPAwB7s5lEeBQMJ_HPAoIAA8AMBbBeg8Nvwf7aAhURD6GWAzQkXMFADAC_BANMGdxzDEM0eS6mZvKVNoz1cIkZuW8J3XhZ41505WXWzXX1qrGK-tV3Tivzj1lX5Q1y4WxJvVuVGqsbd0xOsiVdfpkd4_QbHI7G9_70-e7h_H11K8JZ8LPALJEhDGlmtA8ZGEk0ghElhOOE8EFMM6IIrkSJIpDLeJY4YQynetUhVzRETrffrts6tdWu5UsjUv7DStdt05ywTsvZB149gss6raputUkocBDjiMaddTpjmqTUmdy2ZhSNRv5FU8HXG2Bd2P15mcOsq9BFrJPW_Zpy74G-VmDXMvJ47R7dDrd6nW7_Ef2_8j0Ayj9iBo</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>Atsumi, Tatsuo</creator><creator>Yoshimura, Fuminobu</creator><creator>Sugiyama, Shigeru</creator><general>Blackwell Publishing Ltd</general><general>Blackwell Science Ltd</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060301</creationdate><title>Arginine inhibits Na+-driven flagellar motors of alkaliphilic Bacillus</title><author>Atsumi, Tatsuo ; 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L-arginine has attracted a great deal of attention as an agent for refolding denatured proteins, and the mildness of its effects offer hope for a wide range of potential applications for this substance, including medicines with few side effects. We report that both l- and d-arginine inhibits Na+-driven flagellar motors of alkaliphilic Bacillus by competing with Na+, which we take as evidence that arginine specifically binds to a molecular target.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16499610</pmid><doi>10.1111/j.1574-6968.2006.00117.x</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-1097 |
| ispartof | FEMS microbiology letters, 2006-03, Vol.256 (2), p.224-228 |
| issn | 0378-1097 1574-6968 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current) |
| subjects | alkaliphilic Bacillus amiloride Arginine Arginine - pharmacology Bacillus Bacillus - drug effects Bacillus - physiology Flagella Flagella - drug effects Microbiology Molecular Motor Proteins - drug effects Motors Movement - drug effects Na+‐driven flagellar motors Side effects |
| title | Arginine inhibits Na+-driven flagellar motors of alkaliphilic Bacillus |
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