Arginine inhibits Na+-driven flagellar motors of alkaliphilic Bacillus

Abstract L-arginine has attracted a great deal of attention as an agent for refolding denatured proteins, and the mildness of its effects offer hope for a wide range of potential applications for this substance, including medicines with few side effects. We report that both l- and d-arginine inhibit...

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Veröffentlicht in:	FEMS microbiology letters 2006-03, Vol.256 (2), p.224-228
Hauptverfasser:	Atsumi, Tatsuo, Yoshimura, Fuminobu, Sugiyama, Shigeru
Format:	Artikel
Sprache:	eng
Schlagworte:	alkaliphilic Bacillus amiloride Arginine Arginine - pharmacology Bacillus Bacillus - drug effects Bacillus - physiology Flagella Flagella - drug effects Microbiology Molecular Motor Proteins - drug effects Motors Movement - drug effects Na+‐driven flagellar motors Side effects
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Zusammenfassung:	Abstract L-arginine has attracted a great deal of attention as an agent for refolding denatured proteins, and the mildness of its effects offer hope for a wide range of potential applications for this substance, including medicines with few side effects. We report that both l- and d-arginine inhibits Na+-driven flagellar motors of alkaliphilic Bacillus by competing with Na+, which we take as evidence that arginine specifically binds to a molecular target.
ISSN:	0378-1097 1574-6968
DOI:	10.1111/j.1574-6968.2006.00117.x