Estrogen Dendrimer Conjugates that Preferentially Activate Extranuclear, Nongenomic Versus Genomic Pathways of Estrogen Action

Estrogenic hormones are classically thought to exert their effects by binding to nuclear estrogen receptors and altering target gene transcription, but estrogens can also have nongenomic effects through rapid activation of membrane-initiated kinase cascades. The development of ligands that selective...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2006-03, Vol.20 (3), p.491-502
Hauptverfasser:	Harrington, William R, Kim, Sung Hoon, Funk, Cory C, Madak-Erdogan, Zeynep, Schiff, Rachel, Katzenellenbogen, John A, Katzenellenbogen, Benita S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - drug effects Adaptor Proteins, Signal Transducing - metabolism Binding, Competitive Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cell Membrane - metabolism Cell Proliferation Cytoplasm - metabolism Dendrimers Dose-Response Relationship, Drug Estradiol - metabolism Estradiol - pharmacology Estrogens - metabolism Estrogens - pharmacology Extracellular Matrix - metabolism Extracellular Signal-Regulated MAP Kinases - drug effects Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Regulation - drug effects Genome - drug effects Humans Phosphorylation Polyamines - chemistry Polyamines - metabolism Polyamines - pharmacology Receptors, Estrogen - metabolism Rhodamines - chemistry Shc Signaling Adaptor Proteins Signal Transduction Src Homology 2 Domain-Containing, Transforming Protein 1 src-Family Kinases - drug effects src-Family Kinases - metabolism Tumor Cells, Cultured
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