Atorvastatin Improves Myocardial Perfusion in a Patient With Hypercholesterolemia and Single-Vessel Coronary Disease
Lipid-lowering agents may improve the prognosis in patients with coronary artery disease (CAD) or with risk factors for atherosclerosis. A high dose of atorvastatin (80 mg/d) reduced the LDL cholesterol level in stable patients with CAD and was seen to be as effective as coronary angioplasty in redu...
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| Veröffentlicht in: | Clinical nuclear medicine 2006-03, Vol.31 (3), p.166-167 |
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| container_title | Clinical nuclear medicine |
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| creator | Feola, Mauro Biggi, Alberto Rolfo, Fabrizio Papaleo, Alberto Chauvie, Stephane Scala, Eugenio La Uslenghi, Eugenio |
| description | Lipid-lowering agents may improve the prognosis in patients with coronary artery disease (CAD) or with risk factors for atherosclerosis. A high dose of atorvastatin (80 mg/d) reduced the LDL cholesterol level in stable patients with CAD and was seen to be as effective as coronary angioplasty in reducing the incidence of ischemic events. In patients with acute coronary syndrome, high-dose atorvastatin (80 mg/d) has lowered the incidence of recurrent ischemic events and emergency rehospitalization. We demonstrated that long-term oral low-dose (10 mg/d) administration of atorvastatin improved myocardial uptake of Tc-99m tetrofosmin in a patient with single-vessel coronary artery disease normalizing the plasma level of LDL cholesterol. The normalization of the perfusion pattern was obtained using the same protocol and level of physical stress after 10 months of therapy. |
| doi_str_mv | 10.1097/01.rlu.0000200731.36549.d7 |
| format | Article |
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A high dose of atorvastatin (80 mg/d) reduced the LDL cholesterol level in stable patients with CAD and was seen to be as effective as coronary angioplasty in reducing the incidence of ischemic events. In patients with acute coronary syndrome, high-dose atorvastatin (80 mg/d) has lowered the incidence of recurrent ischemic events and emergency rehospitalization. We demonstrated that long-term oral low-dose (10 mg/d) administration of atorvastatin improved myocardial uptake of Tc-99m tetrofosmin in a patient with single-vessel coronary artery disease normalizing the plasma level of LDL cholesterol. The normalization of the perfusion pattern was obtained using the same protocol and level of physical stress after 10 months of therapy.</description><identifier>ISSN: 0363-9762</identifier><identifier>EISSN: 1536-0229</identifier><identifier>DOI: 10.1097/01.rlu.0000200731.36549.d7</identifier><identifier>PMID: 16495741</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins, Inc</publisher><subject>Anticholesteremic Agents - administration & dosage ; Atorvastatin Calcium ; Coronary Artery Disease - complications ; Coronary Artery Disease - drug therapy ; Coronary Circulation - drug effects ; Heptanoic Acids ; Humans ; Hypercholesterolemia - complications ; Hypercholesterolemia - diagnostic imaging ; Hypercholesterolemia - drug therapy ; Male ; Middle Aged ; Organophosphorus Compounds ; Organotechnetium Compounds ; Pyrroles ; Radionuclide Imaging ; Radiopharmaceuticals ; Treatment Outcome</subject><ispartof>Clinical nuclear medicine, 2006-03, Vol.31 (3), p.166-167</ispartof><rights>2006 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3054-cd79fff75422e3943112e8b9c1eadadd8cf5b13fda332c9d774eb7a0e96463fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16495741$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feola, Mauro</creatorcontrib><creatorcontrib>Biggi, Alberto</creatorcontrib><creatorcontrib>Rolfo, Fabrizio</creatorcontrib><creatorcontrib>Papaleo, Alberto</creatorcontrib><creatorcontrib>Chauvie, Stephane</creatorcontrib><creatorcontrib>Scala, Eugenio La</creatorcontrib><creatorcontrib>Uslenghi, Eugenio</creatorcontrib><title>Atorvastatin Improves Myocardial Perfusion in a Patient With Hypercholesterolemia and Single-Vessel Coronary Disease</title><title>Clinical nuclear medicine</title><addtitle>Clin Nucl Med</addtitle><description>Lipid-lowering agents may improve the prognosis in patients with coronary artery disease (CAD) or with risk factors for atherosclerosis. A high dose of atorvastatin (80 mg/d) reduced the LDL cholesterol level in stable patients with CAD and was seen to be as effective as coronary angioplasty in reducing the incidence of ischemic events. In patients with acute coronary syndrome, high-dose atorvastatin (80 mg/d) has lowered the incidence of recurrent ischemic events and emergency rehospitalization. We demonstrated that long-term oral low-dose (10 mg/d) administration of atorvastatin improved myocardial uptake of Tc-99m tetrofosmin in a patient with single-vessel coronary artery disease normalizing the plasma level of LDL cholesterol. The normalization of the perfusion pattern was obtained using the same protocol and level of physical stress after 10 months of therapy.</description><subject>Anticholesteremic Agents - administration & dosage</subject><subject>Atorvastatin Calcium</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - drug therapy</subject><subject>Coronary Circulation - drug effects</subject><subject>Heptanoic Acids</subject><subject>Humans</subject><subject>Hypercholesterolemia - complications</subject><subject>Hypercholesterolemia - diagnostic imaging</subject><subject>Hypercholesterolemia - drug therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Organophosphorus Compounds</subject><subject>Organotechnetium Compounds</subject><subject>Pyrroles</subject><subject>Radionuclide Imaging</subject><subject>Radiopharmaceuticals</subject><subject>Treatment Outcome</subject><issn>0363-9762</issn><issn>1536-0229</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF1vFCEUhonR2LX6FwzxwrsZ-RpYvGvWjzapsYlfl4SFg4sywxZm2uy_F7ublAQOF895OTwIvaGkp0Srd4T2JS09aYsRojjtuRyE7r16glZ04LIjjOmnaEW45J1Wkp2hF7X-IYRKKsVzdNZOPShBV2i-mHO5s3W2c5zw1bgv-Q4q_nLIzhYfbcI3UMJSY55wAyy-aSBMM_4V5x2-POyhuF1OUGcorYzRYjt5_C1OvxN0P6FWSHiTS55sOeAPsYKt8BI9CzZVeHWq5-jHp4_fN5fd9dfPV5uL685xMojOeaVDCGoQjAHXglPKYL3VjoL11vu1C8OW8uAt58xpr5SArbIEtBSSB8vP0dtjbvvV7dJmNGOsDlKyE-SlGqnkWjMmGvj-CLqSay0QzL7EsU1sKDH_nRtCTXNuHp2bB-fGq9b8-vTKsh3BP7aeJDdAHIH7nJqm-jct91DMDmyadw-RnCjWtVzZboR0bVPB_wEMh5Ef</recordid><startdate>200603</startdate><enddate>200603</enddate><creator>Feola, Mauro</creator><creator>Biggi, Alberto</creator><creator>Rolfo, Fabrizio</creator><creator>Papaleo, Alberto</creator><creator>Chauvie, Stephane</creator><creator>Scala, Eugenio La</creator><creator>Uslenghi, Eugenio</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200603</creationdate><title>Atorvastatin Improves Myocardial Perfusion in a Patient With Hypercholesterolemia and Single-Vessel Coronary Disease</title><author>Feola, Mauro ; Biggi, Alberto ; Rolfo, Fabrizio ; Papaleo, Alberto ; Chauvie, Stephane ; Scala, Eugenio La ; Uslenghi, Eugenio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3054-cd79fff75422e3943112e8b9c1eadadd8cf5b13fda332c9d774eb7a0e96463fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Anticholesteremic Agents - administration & dosage</topic><topic>Atorvastatin Calcium</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Artery Disease - drug therapy</topic><topic>Coronary Circulation - drug effects</topic><topic>Heptanoic Acids</topic><topic>Humans</topic><topic>Hypercholesterolemia - complications</topic><topic>Hypercholesterolemia - diagnostic imaging</topic><topic>Hypercholesterolemia - drug therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Organophosphorus Compounds</topic><topic>Organotechnetium Compounds</topic><topic>Pyrroles</topic><topic>Radionuclide Imaging</topic><topic>Radiopharmaceuticals</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feola, Mauro</creatorcontrib><creatorcontrib>Biggi, Alberto</creatorcontrib><creatorcontrib>Rolfo, Fabrizio</creatorcontrib><creatorcontrib>Papaleo, Alberto</creatorcontrib><creatorcontrib>Chauvie, Stephane</creatorcontrib><creatorcontrib>Scala, Eugenio La</creatorcontrib><creatorcontrib>Uslenghi, Eugenio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feola, Mauro</au><au>Biggi, Alberto</au><au>Rolfo, Fabrizio</au><au>Papaleo, Alberto</au><au>Chauvie, Stephane</au><au>Scala, Eugenio La</au><au>Uslenghi, Eugenio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atorvastatin Improves Myocardial Perfusion in a Patient With Hypercholesterolemia and Single-Vessel Coronary Disease</atitle><jtitle>Clinical nuclear medicine</jtitle><addtitle>Clin Nucl Med</addtitle><date>2006-03</date><risdate>2006</risdate><volume>31</volume><issue>3</issue><spage>166</spage><epage>167</epage><pages>166-167</pages><issn>0363-9762</issn><eissn>1536-0229</eissn><abstract>Lipid-lowering agents may improve the prognosis in patients with coronary artery disease (CAD) or with risk factors for atherosclerosis. 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| ispartof | Clinical nuclear medicine, 2006-03, Vol.31 (3), p.166-167 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Anticholesteremic Agents - administration & dosage Atorvastatin Calcium Coronary Artery Disease - complications Coronary Artery Disease - drug therapy Coronary Circulation - drug effects Heptanoic Acids Humans Hypercholesterolemia - complications Hypercholesterolemia - diagnostic imaging Hypercholesterolemia - drug therapy Male Middle Aged Organophosphorus Compounds Organotechnetium Compounds Pyrroles Radionuclide Imaging Radiopharmaceuticals Treatment Outcome |
| title | Atorvastatin Improves Myocardial Perfusion in a Patient With Hypercholesterolemia and Single-Vessel Coronary Disease |
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