Stromal Expression of MMP-13 Is Required for Melanoma Invasion and Metastasis

Tumor invasion and metastasis of malignant melanoma have been shown to require proteolytic degradation of the extracellular environment achieved primarily by enzymes of the matrix metalloproteinases (MMP) family. We have earlier shown that increased enzyme activity is localized at the border of tumo...

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Veröffentlicht in:	Journal of investigative dermatology 2009-11, Vol.129 (11), p.2686-2693
Hauptverfasser:	Zigrino, Paola, Kuhn, Isolde, Bäuerle, Tobias, Zamek, Jan, Fox, Jay W., Neumann, Susanne, Licht, Alexander, Schorpp-Kistner, Marina, Angel, Peter, Mauch, Cornelia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Dermatology Endothelial Cells - enzymology Endothelial Cells - pathology Gene Expression Regulation, Enzymologic - physiology Macrophages - pathology Matrix Metalloproteinase 13 - genetics Matrix Metalloproteinase 13 - metabolism Medical sciences Melanoma - immunology Melanoma - physiopathology Melanoma - secondary Mice Mice, Inbred C57BL Mice, Mutant Strains Neoplasm Transplantation Neovascularization, Pathologic - immunology Neovascularization, Pathologic - pathology Neovascularization, Pathologic - physiopathology Neutrophils - pathology Skin Neoplasms - immunology Skin Neoplasms - pathology Skin Neoplasms - physiopathology Stromal Cells - enzymology Stromal Cells - pathology Tumors of the skin and soft tissue. Premalignant lesions
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