Body fat and insulin resistance independently predict increased serum C-reactive protein in hyperandrogenic women with polycystic ovary syndrome
ObjectiveIncreased serum C-reactive protein (CRP), an independent predictor of coronary heart disease, was reported in women with polycystic ovary syndrome (PCOS). It remains unclear whether this finding is due to the association between PCOS and either insulin resistance, obesity, or androgen exces...
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| Veröffentlicht in: | European journal of endocrinology 2009-11, Vol.161 (5), p.737-745 |
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| creator | Tosi, Flavia Dorizzi, Romolo Castello, Roberto Maffeis, Claudio Spiazzi, Giovanna Zoppini, Giacomo Muggeo, Michele Moghetti, Paolo |
| description | ObjectiveIncreased serum C-reactive protein (CRP), an independent predictor of coronary heart disease, was reported in women with polycystic ovary syndrome (PCOS). It remains unclear whether this finding is due to the association between PCOS and either insulin resistance, obesity, or androgen excess, which are all common features of this condition. The aims of this study were to assess whether increased serum CRP is a specific feature of PCOS and to investigate the mechanisms underlying this association.Design and methodsSerum high-sensitivity CRP (hs-CRP) was measured in 86 hyperandrogenic women (age 21.6±4.2 years, body mass index (BMI) 23.6±3.5 kg/m2), 50 with PCOS and 36 with idiopathic hyperandrogenism (HA). Thirty-five BMI-matched healthy women were also studied as controls. In these subjects, endocrine and metabolic profiles were assessed. In all hyperandrogenic subjects and 14 controls, insulin sensitivity was measured by the glucose clamp technique. Body fat was measured by bioelectrical impedance.ResultsHs-CRP concentrations were higher in PCOS women (3.43±2.01 mg/l) than in HA subjects and healthy women (2.43±1.04, P |
| doi_str_mv | 10.1530/EJE-09-0379 |
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It remains unclear whether this finding is due to the association between PCOS and either insulin resistance, obesity, or androgen excess, which are all common features of this condition. The aims of this study were to assess whether increased serum CRP is a specific feature of PCOS and to investigate the mechanisms underlying this association.Design and methodsSerum high-sensitivity CRP (hs-CRP) was measured in 86 hyperandrogenic women (age 21.6±4.2 years, body mass index (BMI) 23.6±3.5 kg/m2), 50 with PCOS and 36 with idiopathic hyperandrogenism (HA). Thirty-five BMI-matched healthy women were also studied as controls. In these subjects, endocrine and metabolic profiles were assessed. In all hyperandrogenic subjects and 14 controls, insulin sensitivity was measured by the glucose clamp technique. Body fat was measured by bioelectrical impedance.ResultsHs-CRP concentrations were higher in PCOS women (3.43±2.01 mg/l) than in HA subjects and healthy women (2.43±1.04, P<0.005; and 2.75±0.86 mg/l, P<0.05 respectively versus PCOS). In multiple regression analyses, increased serum hs-CRP was independently predicted by higher body fat and lower insulin sensitivity. However, in lean women, serum-free testosterone was an additional, negative, predictive variable.ConclusionsPCOS is accompanied by a low-grade chronic inflammation. Body fat appears the main determining factor of this finding, which is only partly explained by insulin resistance. At least in lean women, androgen excess per se seems to play an additional, possibly protective, role in this association.</description><identifier>ISSN: 0804-4643</identifier><identifier>EISSN: 1479-683X</identifier><identifier>DOI: 10.1530/EJE-09-0379</identifier><identifier>PMID: 19713424</identifier><language>eng</language><publisher>Bristol: BioScientifica</publisher><subject>Adipose Tissue - metabolism ; Adult ; Biological and medical sciences ; Body Composition - physiology ; C-Reactive Protein - metabolism ; Clinical Study ; Cohort Studies ; Electric Impedance ; Endocrinopathies ; Female ; Female genital diseases ; Fundamental and applied biological sciences. Psychology ; Glucose Clamp Technique ; Gynecology. Andrology. Obstetrics ; Humans ; Hyperandrogenism - blood ; Insulin Resistance - physiology ; Medical sciences ; Non tumoral diseases ; Polycystic Ovary Syndrome - blood ; Regression Analysis ; Vertebrates: endocrinology ; Young Adult</subject><ispartof>European journal of endocrinology, 2009-11, Vol.161 (5), p.737-745</ispartof><rights>2009 European Society of Endocrinology</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b425t-146ec471b627642dd9b5863b8496912cd65ff282647854d7c985a5a09b2524563</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22143798$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19713424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tosi, Flavia</creatorcontrib><creatorcontrib>Dorizzi, Romolo</creatorcontrib><creatorcontrib>Castello, Roberto</creatorcontrib><creatorcontrib>Maffeis, Claudio</creatorcontrib><creatorcontrib>Spiazzi, Giovanna</creatorcontrib><creatorcontrib>Zoppini, Giacomo</creatorcontrib><creatorcontrib>Muggeo, Michele</creatorcontrib><creatorcontrib>Moghetti, Paolo</creatorcontrib><title>Body fat and insulin resistance independently predict increased serum C-reactive protein in hyperandrogenic women with polycystic ovary syndrome</title><title>European journal of endocrinology</title><addtitle>Eur J Endocrinol</addtitle><description>ObjectiveIncreased serum C-reactive protein (CRP), an independent predictor of coronary heart disease, was reported in women with polycystic ovary syndrome (PCOS). It remains unclear whether this finding is due to the association between PCOS and either insulin resistance, obesity, or androgen excess, which are all common features of this condition. The aims of this study were to assess whether increased serum CRP is a specific feature of PCOS and to investigate the mechanisms underlying this association.Design and methodsSerum high-sensitivity CRP (hs-CRP) was measured in 86 hyperandrogenic women (age 21.6±4.2 years, body mass index (BMI) 23.6±3.5 kg/m2), 50 with PCOS and 36 with idiopathic hyperandrogenism (HA). Thirty-five BMI-matched healthy women were also studied as controls. In these subjects, endocrine and metabolic profiles were assessed. In all hyperandrogenic subjects and 14 controls, insulin sensitivity was measured by the glucose clamp technique. Body fat was measured by bioelectrical impedance.ResultsHs-CRP concentrations were higher in PCOS women (3.43±2.01 mg/l) than in HA subjects and healthy women (2.43±1.04, P<0.005; and 2.75±0.86 mg/l, P<0.05 respectively versus PCOS). In multiple regression analyses, increased serum hs-CRP was independently predicted by higher body fat and lower insulin sensitivity. However, in lean women, serum-free testosterone was an additional, negative, predictive variable.ConclusionsPCOS is accompanied by a low-grade chronic inflammation. Body fat appears the main determining factor of this finding, which is only partly explained by insulin resistance. At least in lean women, androgen excess per se seems to play an additional, possibly protective, role in this association.</description><subject>Adipose Tissue - metabolism</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Body Composition - physiology</subject><subject>C-Reactive Protein - metabolism</subject><subject>Clinical Study</subject><subject>Cohort Studies</subject><subject>Electric Impedance</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose Clamp Technique</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Hyperandrogenism - blood</subject><subject>Insulin Resistance - physiology</subject><subject>Medical sciences</subject><subject>Non tumoral diseases</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Regression Analysis</subject><subject>Vertebrates: endocrinology</subject><subject>Young Adult</subject><issn>0804-4643</issn><issn>1479-683X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU-LFDEQxYMo7uzqybvkohdpTdJJOjm6w7gqC14UvDXppNqN9D-T9C79LfzI1jCD3oSQVB4_XhWvCHnB2Vuuavbu8PlQMVuxurGPyI7Lxlba1N8fkx0zTFZSy_qCXOb8kzGONXtKLrhteC2F3JHf13PYaO8KdVOgccrrECeaIMdc3OQBpQAL4DWVYaNLghB9QdUncBkCzZDWke4r_PoS7wGRuQB64LnbFkjom-YfMEVPH-YRJvoQyx1d5mHzWy6ozvcubTRvR26EZ-RJ74YMz8_vFfn24fB1_7G6_XLzaf_-tuqkUKXiUoOXDe-0aLQUIdhOGV13RlptufBBq74XRmjZGCVD461RTjlmO6GEVLq-Iq9PvjjvrxVyaceYPQyDm2Bec6sbbYzmEsE3J9CnOecEfbukOOLILWftcQEtLqBltj0uAOmXZ9u1GyH8Y8-JI_DqDLjs3dBjPj7mv5wQ2LKxBjl-4ro4Zx8x_thH7_7b_A91gqB3</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Tosi, Flavia</creator><creator>Dorizzi, Romolo</creator><creator>Castello, Roberto</creator><creator>Maffeis, Claudio</creator><creator>Spiazzi, Giovanna</creator><creator>Zoppini, Giacomo</creator><creator>Muggeo, Michele</creator><creator>Moghetti, Paolo</creator><general>BioScientifica</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>Body fat and insulin resistance independently predict increased serum C-reactive protein in hyperandrogenic women with polycystic ovary syndrome</title><author>Tosi, Flavia ; Dorizzi, Romolo ; Castello, Roberto ; Maffeis, Claudio ; Spiazzi, Giovanna ; Zoppini, Giacomo ; Muggeo, Michele ; Moghetti, Paolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b425t-146ec471b627642dd9b5863b8496912cd65ff282647854d7c985a5a09b2524563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adipose Tissue - metabolism</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Body Composition - physiology</topic><topic>C-Reactive Protein - metabolism</topic><topic>Clinical Study</topic><topic>Cohort Studies</topic><topic>Electric Impedance</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose Clamp Technique</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Hyperandrogenism - blood</topic><topic>Insulin Resistance - physiology</topic><topic>Medical sciences</topic><topic>Non tumoral diseases</topic><topic>Polycystic Ovary Syndrome - blood</topic><topic>Regression Analysis</topic><topic>Vertebrates: endocrinology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tosi, Flavia</creatorcontrib><creatorcontrib>Dorizzi, Romolo</creatorcontrib><creatorcontrib>Castello, Roberto</creatorcontrib><creatorcontrib>Maffeis, Claudio</creatorcontrib><creatorcontrib>Spiazzi, Giovanna</creatorcontrib><creatorcontrib>Zoppini, Giacomo</creatorcontrib><creatorcontrib>Muggeo, Michele</creatorcontrib><creatorcontrib>Moghetti, Paolo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tosi, Flavia</au><au>Dorizzi, Romolo</au><au>Castello, Roberto</au><au>Maffeis, Claudio</au><au>Spiazzi, Giovanna</au><au>Zoppini, Giacomo</au><au>Muggeo, Michele</au><au>Moghetti, Paolo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body fat and insulin resistance independently predict increased serum C-reactive protein in hyperandrogenic women with polycystic ovary syndrome</atitle><jtitle>European journal of endocrinology</jtitle><addtitle>Eur J Endocrinol</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>161</volume><issue>5</issue><spage>737</spage><epage>745</epage><pages>737-745</pages><issn>0804-4643</issn><eissn>1479-683X</eissn><abstract>ObjectiveIncreased serum C-reactive protein (CRP), an independent predictor of coronary heart disease, was reported in women with polycystic ovary syndrome (PCOS). It remains unclear whether this finding is due to the association between PCOS and either insulin resistance, obesity, or androgen excess, which are all common features of this condition. The aims of this study were to assess whether increased serum CRP is a specific feature of PCOS and to investigate the mechanisms underlying this association.Design and methodsSerum high-sensitivity CRP (hs-CRP) was measured in 86 hyperandrogenic women (age 21.6±4.2 years, body mass index (BMI) 23.6±3.5 kg/m2), 50 with PCOS and 36 with idiopathic hyperandrogenism (HA). Thirty-five BMI-matched healthy women were also studied as controls. In these subjects, endocrine and metabolic profiles were assessed. In all hyperandrogenic subjects and 14 controls, insulin sensitivity was measured by the glucose clamp technique. Body fat was measured by bioelectrical impedance.ResultsHs-CRP concentrations were higher in PCOS women (3.43±2.01 mg/l) than in HA subjects and healthy women (2.43±1.04, P<0.005; and 2.75±0.86 mg/l, P<0.05 respectively versus PCOS). In multiple regression analyses, increased serum hs-CRP was independently predicted by higher body fat and lower insulin sensitivity. However, in lean women, serum-free testosterone was an additional, negative, predictive variable.ConclusionsPCOS is accompanied by a low-grade chronic inflammation. Body fat appears the main determining factor of this finding, which is only partly explained by insulin resistance. At least in lean women, androgen excess per se seems to play an additional, possibly protective, role in this association.</abstract><cop>Bristol</cop><pub>BioScientifica</pub><pmid>19713424</pmid><doi>10.1530/EJE-09-0379</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adipose Tissue - metabolism Adult Biological and medical sciences Body Composition - physiology C-Reactive Protein - metabolism Clinical Study Cohort Studies Electric Impedance Endocrinopathies Female Female genital diseases Fundamental and applied biological sciences. Psychology Glucose Clamp Technique Gynecology. Andrology. Obstetrics Humans Hyperandrogenism - blood Insulin Resistance - physiology Medical sciences Non tumoral diseases Polycystic Ovary Syndrome - blood Regression Analysis Vertebrates: endocrinology Young Adult |
| title | Body fat and insulin resistance independently predict increased serum C-reactive protein in hyperandrogenic women with polycystic ovary syndrome |
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