Click chemistry as a route to cyclic tetrapeptide analogues: synthesis of cyclo-[Pro-Val-psi(triazole)-Pro-Tyr]

Despite the plethora of techniques to cyclize small peptides, a synthesis of cyclo-[(L)Pro-(L)Tyr-(L)Pro-(L)Val], a potent tyrosinase inhibitor, remains elusive because of the unfavorable transition state leading to the cyclic product. Herein, we report the successful synthesis of its triazole analo...

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Veröffentlicht in:	Organic letters 2006-03, Vol.8 (5), p.919-922
Hauptverfasser:	Bock, Victoria D, Perciaccante, Rossana, Jansen, T Paul, Hiemstra, Henk, van Maarseveen, Jan H
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Copper - chemistry Cyclization Molecular Structure Oligopeptides - chemical synthesis Oligopeptides - chemistry Peptides - chemical synthesis Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry Stereoisomerism
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