Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics

The BCL-2 homology domain 3 (BH3)-only protein, B-cell lymphoma 2 interacting mediator of cell death (BIM) is a potent pro-apoptotic protein belonging to the B-cell lymphoma 2 protein family. In recent years, advances in basic biology have provided a clearer picture of how BIM kills cells and how BI...

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Veröffentlicht in:	The FEBS journal 2009-11, Vol.276 (21), p.6050-6062
Hauptverfasser:	Gillings, Annette S, Balmanno, Kathryn, Wiggins, Ceri M, Johnson, Mark, Cook, Simon J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis Regulatory Proteins - physiology Autophagy B-cell lymphoma 2 (BCL-2) BCL-2-interacting mediator of cell death (BIM) Bcl-2-Like Protein 11 Biochemistry breakpoint cluster region/Abelson murine leukaemia viral oncogene (BCR/ABL) Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Cell Survival Chemotherapy epidermal growth factor receptor (EGFR) extracellular signal-regulated kinase 1/2 (ERK1/2) Extracellular Signal-Regulated MAP Kinases - metabolism Fusion Proteins, bcr-abl - antagonists & inhibitors Humans Kinases Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Membrane Proteins - physiology Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors mitogen-MAPK or ERK Kinase 1/2 (MEK1/2) Mutation Neoplasms - drug therapy Neoplasms - pathology Oncogenes Oncology protein kinase B (PKB) Protein Processing, Post-Translational Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins B-raf - genetics Receptor, Epidermal Growth Factor - genetics ribosomal protein S6 kinase (RSK) Signal Transduction v-raf murine sarcoma viral oncogene homologue B1 (BRAF)
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