JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin

Activation of Janus kinase 2 (JAK2) by chromosomal translocations or point mutations is a frequent event in haematological malignancies. JAK2 is a non-receptor tyrosine kinase that regulates several cellular processes by inducing cytoplasmic signalling cascades. Here we show that human JAK2 is prese...

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Veröffentlicht in:	Nature (London) 2009-10, Vol.461 (7265), p.819-822
Hauptverfasser:	Dawson, Mark A, Bannister, Andrew J, Göttgens, Berthold, Foster, Samuel D, Bartke, Till, Green, Anthony R, Kouzarides, Tony
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Binding Sites Cell Line Cell Nucleus - enzymology Chromatin - chemistry Chromatin - metabolism Chromobox Protein Homolog 5 Chromosomal Proteins, Non-Histone - metabolism DNA-Binding Proteins - genetics Gene Expression Regulation, Neoplastic Hematopoiesis - genetics Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - enzymology Histones - chemistry Histones - genetics Histones - metabolism Humans Janus Kinase 2 - antagonists & inhibitors Janus Kinase 2 - metabolism Leukemia - enzymology Leukemia - genetics Leukemia - metabolism Leukemia - pathology LIM Domain Proteins Metalloproteins - genetics Mice Oncogenes - genetics Phosphorylation Promoter Regions, Genetic - genetics Protein Binding Proto-Oncogene Proteins Signal Transduction Tyrosine - metabolism
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