Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: The discovery of GW0385

A novel series of P1 modified HIV protease inhibitors was synthesized and evaluated for in vitro antiviral activity against wild-type virus and protease inhibitor-resistant viruses. Optimization of the P1 moiety resulted in compounds with femtomolar enzyme activities and cellular antiviral activitie...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-04, Vol.16 (7), p.1788-1794
Hauptverfasser:	Miller, John F., Andrews, C. Webster, Brieger, Michael, Furfine, Eric S., Hale, Michael R., Hanlon, Mary H., Hazen, Richard J., Kaldor, Istvan, McLean, Ed W., Reynolds, David, Sammond, Douglas M., Spaltenstein, Andrew, Tung, Roger, Turner, Elizabeth M., Xu, Robert X., Sherrill, Ronald G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral Antiviral Antiviral agents Arylsulfonamide Biological and medical sciences Brecanavir Drug resistance GW0385 HIV protease HIV Protease Inhibitors - chemistry HIV Protease Inhibitors - pharmacology Human immunodeficiency virus Medical sciences Molecular Structure Pharmacology. Drug treatments Sulfonamides - chemistry Sulfonamides - pharmacology
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