Developmental haemostasis Impact for clinical haemostasis laboratories
Developmental haemostasis is a concept, now universally accepted, introduced by Andrew et al. in the late 1980's. However, coagulation analysers and reagents have changed significantly over the past 15 years. Coagulation testing is known to be sensitive to changes in individual reagents and ana...
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| Veröffentlicht in: | Thrombosis and haemostasis 2006-02, Vol.95 (2), p.362-372 |
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| creator | MONAGLE, Paul BARNES, Chris AULDIST, Alex CROCK, Cathy ROY, Neil ROWLANDS, Shelley IGNJATOVIC, Vera FURMEDGE, Janine NEWALL, Fiona CHAN, Anthony DE ROSA, Lidia HAMILTON, Simone RAGG, Philip ROBINSON, Stephen |
| description | Developmental haemostasis is a concept, now universally accepted, introduced by Andrew et al. in the late 1980's. However, coagulation analysers and reagents have changed significantly over the past 15 years. Coagulation testing is known to be sensitive to changes in individual reagents and analysers. We hypothesised that the reference ranges developed by Andrew et al. may not be appropriate for use in a modern coagulation laboratory. Our study was designed to determine whether a current day coagulation testing system (STA Compact analyser and Diagnostica Stago reagent system) was sensitive to age-related changes in coagulation assays. This is the first large scale study since Andrew et al. to determine the age associated numerical changes in coagulation proteins. Our results confirm the concepts of developmental haemostasis elucidated by Andrew et al. However, our results clearly demonstrate that the absolute values of reference ranges for coagulation assays in neonates and children vary with analyser and reagent systems. The results confirm the need for coagulation laboratories to develop age-related reference ranges specific to their own testing systems. Without this, accurate diagnosis and management of neonates and children with suspected bleeding or clotting disorders is not possible. Finally we present age related reference ranges for D-dimers, TFPI, and endogenous thrombin potential, previously not described. |
| doi_str_mv | 10.1160/TH05-01-0047 |
| format | Article |
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However, coagulation analysers and reagents have changed significantly over the past 15 years. Coagulation testing is known to be sensitive to changes in individual reagents and analysers. We hypothesised that the reference ranges developed by Andrew et al. may not be appropriate for use in a modern coagulation laboratory. Our study was designed to determine whether a current day coagulation testing system (STA Compact analyser and Diagnostica Stago reagent system) was sensitive to age-related changes in coagulation assays. This is the first large scale study since Andrew et al. to determine the age associated numerical changes in coagulation proteins. Our results confirm the concepts of developmental haemostasis elucidated by Andrew et al. However, our results clearly demonstrate that the absolute values of reference ranges for coagulation assays in neonates and children vary with analyser and reagent systems. The results confirm the need for coagulation laboratories to develop age-related reference ranges specific to their own testing systems. Without this, accurate diagnosis and management of neonates and children with suspected bleeding or clotting disorders is not possible. Finally we present age related reference ranges for D-dimers, TFPI, and endogenous thrombin potential, previously not described.</description><identifier>ISSN: 0340-6245</identifier><identifier>EISSN: 2567-689X</identifier><identifier>DOI: 10.1160/TH05-01-0047</identifier><identifier>PMID: 16493500</identifier><identifier>CODEN: THHADQ</identifier><language>eng</language><publisher>Stuttgart: Schattauer Verlag für Medizin und Naturwissenschaften</publisher><subject>Adolescent ; Adult ; Age Factors ; Biological and medical sciences ; Blood Coagulation Tests - instrumentation ; Blood Coagulation Tests - standards ; Blood coagulation. Blood cells ; Child ; Child, Preschool ; Clinical Laboratory Techniques ; developmental haemostasis ; Fibrin Fibrinogen Degradation Products - standards ; Fundamental and applied biological sciences. Psychology ; Hematologic and hematopoietic diseases ; Hemostasis ; Human Development - physiology ; Humans ; Infant ; Infant, Newborn ; Laboratories, Hospital ; Lipoproteins - standards ; Medical sciences ; Molecular and cellular biology ; paediatric ; Platelet diseases and coagulopathies ; Reference ranges ; Reference Values ; Thrombin - standards</subject><ispartof>Thrombosis and haemostasis, 2006-02, Vol.95 (2), p.362-372</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17467604$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16493500$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MONAGLE, Paul</creatorcontrib><creatorcontrib>BARNES, Chris</creatorcontrib><creatorcontrib>AULDIST, Alex</creatorcontrib><creatorcontrib>CROCK, Cathy</creatorcontrib><creatorcontrib>ROY, Neil</creatorcontrib><creatorcontrib>ROWLANDS, Shelley</creatorcontrib><creatorcontrib>IGNJATOVIC, Vera</creatorcontrib><creatorcontrib>FURMEDGE, Janine</creatorcontrib><creatorcontrib>NEWALL, Fiona</creatorcontrib><creatorcontrib>CHAN, Anthony</creatorcontrib><creatorcontrib>DE ROSA, Lidia</creatorcontrib><creatorcontrib>HAMILTON, Simone</creatorcontrib><creatorcontrib>RAGG, Philip</creatorcontrib><creatorcontrib>ROBINSON, Stephen</creatorcontrib><title>Developmental haemostasis Impact for clinical haemostasis laboratories</title><title>Thrombosis and haemostasis</title><addtitle>Thromb Haemost</addtitle><description>Developmental haemostasis is a concept, now universally accepted, introduced by Andrew et al. in the late 1980's. However, coagulation analysers and reagents have changed significantly over the past 15 years. Coagulation testing is known to be sensitive to changes in individual reagents and analysers. We hypothesised that the reference ranges developed by Andrew et al. may not be appropriate for use in a modern coagulation laboratory. Our study was designed to determine whether a current day coagulation testing system (STA Compact analyser and Diagnostica Stago reagent system) was sensitive to age-related changes in coagulation assays. This is the first large scale study since Andrew et al. to determine the age associated numerical changes in coagulation proteins. Our results confirm the concepts of developmental haemostasis elucidated by Andrew et al. However, our results clearly demonstrate that the absolute values of reference ranges for coagulation assays in neonates and children vary with analyser and reagent systems. The results confirm the need for coagulation laboratories to develop age-related reference ranges specific to their own testing systems. Without this, accurate diagnosis and management of neonates and children with suspected bleeding or clotting disorders is not possible. Finally we present age related reference ranges for D-dimers, TFPI, and endogenous thrombin potential, previously not described.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Blood Coagulation Tests - instrumentation</subject><subject>Blood Coagulation Tests - standards</subject><subject>Blood coagulation. Blood cells</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical Laboratory Techniques</subject><subject>developmental haemostasis</subject><subject>Fibrin Fibrinogen Degradation Products - standards</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hemostasis</subject><subject>Human Development - physiology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Laboratories, Hospital</subject><subject>Lipoproteins - standards</subject><subject>Medical sciences</subject><subject>Molecular and cellular biology</subject><subject>paediatric</subject><subject>Platelet diseases and coagulopathies</subject><subject>Reference ranges</subject><subject>Reference Values</subject><subject>Thrombin - standards</subject><issn>0340-6245</issn><issn>2567-689X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNq1kcFu1DAQQC0EoqVw44z2AicCk8Sxs0dUKK1UiUuRuFnO7FgxiuPgcVrx93i1K1r1DKc5zNM8-VmI1zV8qGsFH28uoaugrgCkfiJOm07pSvXbH0_FKbQSKtXI7kS8YP4JUCu57Z6Lk_1sO4BTcfGZbmmKS6A522kzWgqRs2XPm6uwWMwbF9MGJz97fLSf7BCTzTF54pfimbMT06vjPBPfL77cnF9W19--Xp1_uq5QbvtcUd-iG0jZwdVatUQDtU3Ta3AEsnYAW90TtrhDqaghcIPGRqPtnB1QQdOeiXeHu0uKv1bibIJnpGmyM8WVjdKq71qpC_j-AGKKzImcWZIPNv02NZh9N7PvZqA2-24Ff3O8uw6BdvfwMVQB3h4ByyWES3ZGz_eclkUNsnD-wDGONme7UvoL5THFMMTSzth5Zx60NBjnXH6gLBKO_paMZ17JlKsm2HllTH7JptO9NjzGOzPmMBUX_kMXL4TeTo99xRL-v-XBq_4AcW70Uw</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>MONAGLE, Paul</creator><creator>BARNES, Chris</creator><creator>AULDIST, Alex</creator><creator>CROCK, Cathy</creator><creator>ROY, Neil</creator><creator>ROWLANDS, Shelley</creator><creator>IGNJATOVIC, Vera</creator><creator>FURMEDGE, Janine</creator><creator>NEWALL, Fiona</creator><creator>CHAN, Anthony</creator><creator>DE ROSA, Lidia</creator><creator>HAMILTON, Simone</creator><creator>RAGG, Philip</creator><creator>ROBINSON, Stephen</creator><general>Schattauer Verlag für Medizin und Naturwissenschaften</general><general>Schattauer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060201</creationdate><title>Developmental haemostasis Impact for clinical haemostasis laboratories</title><author>MONAGLE, Paul ; BARNES, Chris ; AULDIST, Alex ; CROCK, Cathy ; ROY, Neil ; ROWLANDS, Shelley ; IGNJATOVIC, Vera ; FURMEDGE, Janine ; NEWALL, Fiona ; CHAN, Anthony ; DE ROSA, Lidia ; HAMILTON, Simone ; RAGG, Philip ; ROBINSON, Stephen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-e83cfbe6abf1763eebe322870fe041f00978ec3cdc46e2e0fb7c27ca5fabc6023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Blood Coagulation Tests - instrumentation</topic><topic>Blood Coagulation Tests - standards</topic><topic>Blood coagulation. Blood cells</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical Laboratory Techniques</topic><topic>developmental haemostasis</topic><topic>Fibrin Fibrinogen Degradation Products - standards</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hemostasis</topic><topic>Human Development - physiology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Laboratories, Hospital</topic><topic>Lipoproteins - standards</topic><topic>Medical sciences</topic><topic>Molecular and cellular biology</topic><topic>paediatric</topic><topic>Platelet diseases and coagulopathies</topic><topic>Reference ranges</topic><topic>Reference Values</topic><topic>Thrombin - standards</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MONAGLE, Paul</creatorcontrib><creatorcontrib>BARNES, Chris</creatorcontrib><creatorcontrib>AULDIST, Alex</creatorcontrib><creatorcontrib>CROCK, Cathy</creatorcontrib><creatorcontrib>ROY, Neil</creatorcontrib><creatorcontrib>ROWLANDS, Shelley</creatorcontrib><creatorcontrib>IGNJATOVIC, Vera</creatorcontrib><creatorcontrib>FURMEDGE, Janine</creatorcontrib><creatorcontrib>NEWALL, Fiona</creatorcontrib><creatorcontrib>CHAN, Anthony</creatorcontrib><creatorcontrib>DE ROSA, Lidia</creatorcontrib><creatorcontrib>HAMILTON, Simone</creatorcontrib><creatorcontrib>RAGG, Philip</creatorcontrib><creatorcontrib>ROBINSON, Stephen</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis and haemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MONAGLE, Paul</au><au>BARNES, Chris</au><au>AULDIST, Alex</au><au>CROCK, Cathy</au><au>ROY, Neil</au><au>ROWLANDS, Shelley</au><au>IGNJATOVIC, Vera</au><au>FURMEDGE, Janine</au><au>NEWALL, Fiona</au><au>CHAN, Anthony</au><au>DE ROSA, Lidia</au><au>HAMILTON, Simone</au><au>RAGG, Philip</au><au>ROBINSON, Stephen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Developmental haemostasis Impact for clinical haemostasis laboratories</atitle><jtitle>Thrombosis and haemostasis</jtitle><addtitle>Thromb Haemost</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>95</volume><issue>2</issue><spage>362</spage><epage>372</epage><pages>362-372</pages><issn>0340-6245</issn><eissn>2567-689X</eissn><coden>THHADQ</coden><abstract>Developmental haemostasis is a concept, now universally accepted, introduced by Andrew et al. in the late 1980's. However, coagulation analysers and reagents have changed significantly over the past 15 years. Coagulation testing is known to be sensitive to changes in individual reagents and analysers. We hypothesised that the reference ranges developed by Andrew et al. may not be appropriate for use in a modern coagulation laboratory. Our study was designed to determine whether a current day coagulation testing system (STA Compact analyser and Diagnostica Stago reagent system) was sensitive to age-related changes in coagulation assays. This is the first large scale study since Andrew et al. to determine the age associated numerical changes in coagulation proteins. Our results confirm the concepts of developmental haemostasis elucidated by Andrew et al. However, our results clearly demonstrate that the absolute values of reference ranges for coagulation assays in neonates and children vary with analyser and reagent systems. The results confirm the need for coagulation laboratories to develop age-related reference ranges specific to their own testing systems. Without this, accurate diagnosis and management of neonates and children with suspected bleeding or clotting disorders is not possible. Finally we present age related reference ranges for D-dimers, TFPI, and endogenous thrombin potential, previously not described.</abstract><cop>Stuttgart</cop><pub>Schattauer Verlag für Medizin und Naturwissenschaften</pub><pmid>16493500</pmid><doi>10.1160/TH05-01-0047</doi><tpages>11</tpages></addata></record> |
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| ispartof | Thrombosis and haemostasis, 2006-02, Vol.95 (2), p.362-372 |
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| subjects | Adolescent Adult Age Factors Biological and medical sciences Blood Coagulation Tests - instrumentation Blood Coagulation Tests - standards Blood coagulation. Blood cells Child Child, Preschool Clinical Laboratory Techniques developmental haemostasis Fibrin Fibrinogen Degradation Products - standards Fundamental and applied biological sciences. Psychology Hematologic and hematopoietic diseases Hemostasis Human Development - physiology Humans Infant Infant, Newborn Laboratories, Hospital Lipoproteins - standards Medical sciences Molecular and cellular biology paediatric Platelet diseases and coagulopathies Reference ranges Reference Values Thrombin - standards |
| title | Developmental haemostasis Impact for clinical haemostasis laboratories |
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