Membrane type-1 matrix metalloprotease-independent activation of pro-matrix metalloprotease-2 by proprotein convertases

Matrix metalloprotease-2 is implicated in many biological processes and degrades extracellular and non-extracellular matrix molecules. Matrix metalloprotease-2 maintains a latent state through a cysteine-zinc ion pairing which, when disrupted, results in full enzyme activation. This pairing can be d...

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Veröffentlicht in:	The FEBS journal 2009-11, Vol.276 (21), p.6271-6284
Hauptverfasser:	Koo, Bon-Hun, Kim, Hee-Hyun, Park, Michael Y, Jeon, Ok-Hee, Kim, Doo-Sik
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biochemistry Cells, Cultured Cellular biology Enzyme Activation Enzyme Precursors - metabolism furin Gelatinases - metabolism Humans Matrix Metalloproteinase 14 - physiology membrane type-1 matrix metalloprotease (MT1-MMP) Molecular biology Molecular Sequence Data Peptides pro-matrix metalloprotease-2 (pro-MMP-2) pro-MMP-2 activation Proprotein Convertase 5 - physiology proprotein convertases Proprotein Convertases - physiology Proteases Serine Endopeptidases - physiology
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