$Genetic variation in the GDF5 region is associated with osteoarthritis, height, hip axis length and fracture risk: the Rotterdam study$

Genetic variation in the GDF5 region is associated with osteoarthritis, height, hip axis length and fracture risk: the Rotterdam study

Background:A polymorphism (rs143383; T to C) near the GDF5 gene has been associated with height and osteoarthritis (OA), but debate exists about whether its primary biological action is directed to cartilage or bone.Objective:To study the association between genetic variation in the GDF5 region and...

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Veröffentlicht in:	Annals of the rheumatic diseases 2009-11, Vol.68 (11), p.1754-1760
Hauptverfasser:	Vaes, R B A, Rivadeneira, F, Kerkhof, J M, Hofman, A, Pols, H A P, Uitterlinden, A G, van Meurs, J B J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anthropometry - methods Biological and medical sciences Body Height - genetics Bone density Bones Diseases of the osteoarticular system Female Fractures Fractures, Bone - epidemiology Fractures, Bone - genetics Genetic Predisposition to Disease Genotype Growth Differentiation Factor 5 - genetics Hand Joints - diagnostic imaging Hip Joint - pathology Humans Injuries of the limb. Injuries of the spine Male Medical sciences Middle Aged Miscellaneous. Osteoarticular involvement in other diseases Netherlands - epidemiology Osteoarthritis Osteoarthritis - diagnostic imaging Osteoarthritis - epidemiology Osteoarthritis - genetics Osteoarthritis, Knee - diagnostic imaging Osteoarthritis, Knee - epidemiology Osteoarthritis, Knee - genetics Osteoporosis Phenotype Population Prospective Studies Radiography Studies Traumas. Diseases due to physical agents Women
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