Effects of Parecoxib on Plasma Protein Extravasation and c-Fos Expression in the Rat

Objective.—We aimed to investigate the effects of the cyclooxygenases‐2 (COX‐2) inhibitor parecoxib on meningeal plasma protein extravasation (PPE) and on c‐fos expression in the nucleus trigeminalis caudalis in an animal model of trigeminovascular activation. Background.—Recent reports about the ef...

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Veröffentlicht in:	Headache 2006-02, Vol.46 (2), p.276-285
Hauptverfasser:	Schuh-Hofer, Sigrid, Tayefeh, Mandana, Reuter, Uwe, Dirnagl, Ulrich, Arnold, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive agents Biological and medical sciences Blood Proteins - metabolism c-fos expression Capillary Permeability - drug effects Cardiovascular system Cyclooxygenase 2 Inhibitors - pharmacology cyclooxygenase-2 Dura Mater - blood supply Dura Mater - drug effects Dura Mater - metabolism Isoxazoles - pharmacology Male Medical sciences migraine neurogenic inflammation Neurology Neuropharmacology Neuroprotective agent parecoxib Pharmacology. Drug treatments Proto-Oncogene Proteins c-fos - metabolism Rats Rats, Sprague-Dawley Vascular diseases and vascular malformations of the nervous system
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