BMD and Body Composition in Children and Young Patients Affected by Cystic Fibrosis
Longer survival in cystic fibrosis has led to more bone complications. One hundred thirty‐six young patients were studied for 12‐24 months. Low BMD was found in 66%. Fat mass and lean mass were also reduced. Impaired pulmonary function and total steroid dose had the greatest negative influence on bo...
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| Veröffentlicht in: | Journal of bone and mineral research 2006-03, Vol.21 (3), p.388-396 |
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| container_title | Journal of bone and mineral research |
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| creator | Bianchi, Maria Luisa Romano, Giovanna Saraifoger, Silvia Costantini, Diana Limonta, Cristina Colombo, Carla |
| description | Longer survival in cystic fibrosis has led to more bone complications. One hundred thirty‐six young patients were studied for 12‐24 months. Low BMD was found in 66%. Fat mass and lean mass were also reduced. Impaired pulmonary function and total steroid dose had the greatest negative influence on bone.
Introduction: Low BMD is reported as a frequent complication in adult patients affected by cystic fibrosis (CF), but the available data are less consistent for younger patients.
Materials and Methods: This study was designed to evaluate BMD longitudinally over 12‐24 months in a sample of 136 young patients (3‐24 years of age) and to investigate its major determinants. BMC and body composition were also evaluated.
Results: BMD (expressed as Z score) of spine and of total body was reduced in 66% of patients. The prevalence of low BMD was the same in children, adolescents, and young adults. The main determinants of BMD were forced expiratory volume in 1 s (FEV1; as an index of pulmonary function), puberty, platelet count (as an index of portal hypertension), and cumulative steroid dose. Changes of FEV1 over time influenced BMD changes. Bone mass, fat mass (FM) and fat‐free (lean) mass (FFM) were reduced in CF patients at both total body and subregions (trunk, limbs). Lean mass influenced BMD of total body and lower limbs, whereas fat mass (and BMI) influenced spine BMD. FEV1 also influenced FFM.
Conclusions: Low BMD was present in a significant proportion of CF patients, independent of sex and age. BMD depended on pulmonary function, steroid dose, and presence of advanced liver disease. Pulmonary function and puberty were the main stimuli for the increase of BMD over time. CF also altered body composition, and FFM was influenced by pulmonary function. |
| doi_str_mv | 10.1359/JBMR.051106 |
| format | Article |
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Introduction: Low BMD is reported as a frequent complication in adult patients affected by cystic fibrosis (CF), but the available data are less consistent for younger patients.
Materials and Methods: This study was designed to evaluate BMD longitudinally over 12‐24 months in a sample of 136 young patients (3‐24 years of age) and to investigate its major determinants. BMC and body composition were also evaluated.
Results: BMD (expressed as Z score) of spine and of total body was reduced in 66% of patients. The prevalence of low BMD was the same in children, adolescents, and young adults. The main determinants of BMD were forced expiratory volume in 1 s (FEV1; as an index of pulmonary function), puberty, platelet count (as an index of portal hypertension), and cumulative steroid dose. Changes of FEV1 over time influenced BMD changes. Bone mass, fat mass (FM) and fat‐free (lean) mass (FFM) were reduced in CF patients at both total body and subregions (trunk, limbs). Lean mass influenced BMD of total body and lower limbs, whereas fat mass (and BMI) influenced spine BMD. FEV1 also influenced FFM.
Conclusions: Low BMD was present in a significant proportion of CF patients, independent of sex and age. BMD depended on pulmonary function, steroid dose, and presence of advanced liver disease. Pulmonary function and puberty were the main stimuli for the increase of BMD over time. CF also altered body composition, and FFM was influenced by pulmonary function.</description><identifier>ISSN: 0884-0431</identifier><identifier>EISSN: 1523-4681</identifier><identifier>DOI: 10.1359/JBMR.051106</identifier><identifier>PMID: 16491286</identifier><identifier>CODEN: JBMREJ</identifier><language>eng</language><publisher>Washington, DC: John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR)</publisher><subject>Absorptiometry, Photon ; Adolescent ; Biological and medical sciences ; BMD ; body composition ; Body Mass Index ; Bone Density ; bone mass ; Child ; cystic fibrosis ; Cystic Fibrosis - metabolism ; Cystic Fibrosis - pathology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Longitudinal Studies ; Lumbar Vertebrae - diagnostic imaging ; Male ; pediatrics ; Skeleton and joints ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Journal of bone and mineral research, 2006-03, Vol.21 (3), p.388-396</ispartof><rights>Copyright © 2006 ASBMR</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3176-6a447695a2b2952bf1b42001d97b3f1e3c5300e7883501145cdf7e8e836dfb283</citedby><cites>FETCH-LOGICAL-c3176-6a447695a2b2952bf1b42001d97b3f1e3c5300e7883501145cdf7e8e836dfb283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1359%2FJBMR.051106$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1359%2FJBMR.051106$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17589553$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16491286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bianchi, Maria Luisa</creatorcontrib><creatorcontrib>Romano, Giovanna</creatorcontrib><creatorcontrib>Saraifoger, Silvia</creatorcontrib><creatorcontrib>Costantini, Diana</creatorcontrib><creatorcontrib>Limonta, Cristina</creatorcontrib><creatorcontrib>Colombo, Carla</creatorcontrib><title>BMD and Body Composition in Children and Young Patients Affected by Cystic Fibrosis</title><title>Journal of bone and mineral research</title><addtitle>J Bone Miner Res</addtitle><description>Longer survival in cystic fibrosis has led to more bone complications. One hundred thirty‐six young patients were studied for 12‐24 months. Low BMD was found in 66%. Fat mass and lean mass were also reduced. Impaired pulmonary function and total steroid dose had the greatest negative influence on bone.
Introduction: Low BMD is reported as a frequent complication in adult patients affected by cystic fibrosis (CF), but the available data are less consistent for younger patients.
Materials and Methods: This study was designed to evaluate BMD longitudinally over 12‐24 months in a sample of 136 young patients (3‐24 years of age) and to investigate its major determinants. BMC and body composition were also evaluated.
Results: BMD (expressed as Z score) of spine and of total body was reduced in 66% of patients. The prevalence of low BMD was the same in children, adolescents, and young adults. The main determinants of BMD were forced expiratory volume in 1 s (FEV1; as an index of pulmonary function), puberty, platelet count (as an index of portal hypertension), and cumulative steroid dose. Changes of FEV1 over time influenced BMD changes. Bone mass, fat mass (FM) and fat‐free (lean) mass (FFM) were reduced in CF patients at both total body and subregions (trunk, limbs). Lean mass influenced BMD of total body and lower limbs, whereas fat mass (and BMI) influenced spine BMD. FEV1 also influenced FFM.
Conclusions: Low BMD was present in a significant proportion of CF patients, independent of sex and age. BMD depended on pulmonary function, steroid dose, and presence of advanced liver disease. Pulmonary function and puberty were the main stimuli for the increase of BMD over time. CF also altered body composition, and FFM was influenced by pulmonary function.</description><subject>Absorptiometry, Photon</subject><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>BMD</subject><subject>body composition</subject><subject>Body Mass Index</subject><subject>Bone Density</subject><subject>bone mass</subject><subject>Child</subject><subject>cystic fibrosis</subject><subject>Cystic Fibrosis - metabolism</subject><subject>Cystic Fibrosis - pathology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Male</subject><subject>pediatrics</subject><subject>Skeleton and joints</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>0884-0431</issn><issn>1523-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90DtPwzAQB3ALgWgpTOzICywo5S6OHWdsA-WhViAeA1PkODYYpUmJU6F-e1JaqRvT3fC7h_6EnCIMkfHk6mE8ex4CRwSxR_rIQxZEQuI-6YOUUQARwx458v4LAAQX4pD0UEQJhlL0yct4dk1VVdBxXaxoWs8XtXetqyvqKpp-urJoTPUH3utl9UGfVOtM1Xo6stbo1hQ078ZWvnWaTlzedNP-mBxYVXpzsq0D8ja5eU3vgunj7X06mgaaYSwCoaIoFglXYR4mPMwt5lEIgEUS58yiYZozABNLyTggRlwXNjbSSCYKm4eSDcjFZu-iqb-XxrfZ3HltylJVpl76TMRCMuDQwcsN1N1_vjE2WzRurppVhpCtM8zWGWabDDt9tl27zOem2NltaB043wLltSptoyrt_M7FXCacs87FG_fjSrP67-ZfzwWHEIF1L_wCPcWHEQ</recordid><startdate>200603</startdate><enddate>200603</enddate><creator>Bianchi, Maria Luisa</creator><creator>Romano, Giovanna</creator><creator>Saraifoger, Silvia</creator><creator>Costantini, Diana</creator><creator>Limonta, Cristina</creator><creator>Colombo, Carla</creator><general>John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR)</general><general>American Society for Bone and Mineral Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200603</creationdate><title>BMD and Body Composition in Children and Young Patients Affected by Cystic Fibrosis</title><author>Bianchi, Maria Luisa ; Romano, Giovanna ; Saraifoger, Silvia ; Costantini, Diana ; Limonta, Cristina ; Colombo, Carla</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3176-6a447695a2b2952bf1b42001d97b3f1e3c5300e7883501145cdf7e8e836dfb283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Absorptiometry, Photon</topic><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>BMD</topic><topic>body composition</topic><topic>Body Mass Index</topic><topic>Bone Density</topic><topic>bone mass</topic><topic>Child</topic><topic>cystic fibrosis</topic><topic>Cystic Fibrosis - metabolism</topic><topic>Cystic Fibrosis - pathology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Male</topic><topic>pediatrics</topic><topic>Skeleton and joints</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bianchi, Maria Luisa</creatorcontrib><creatorcontrib>Romano, Giovanna</creatorcontrib><creatorcontrib>Saraifoger, Silvia</creatorcontrib><creatorcontrib>Costantini, Diana</creatorcontrib><creatorcontrib>Limonta, Cristina</creatorcontrib><creatorcontrib>Colombo, Carla</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of bone and mineral research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bianchi, Maria Luisa</au><au>Romano, Giovanna</au><au>Saraifoger, Silvia</au><au>Costantini, Diana</au><au>Limonta, Cristina</au><au>Colombo, Carla</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BMD and Body Composition in Children and Young Patients Affected by Cystic Fibrosis</atitle><jtitle>Journal of bone and mineral research</jtitle><addtitle>J Bone Miner Res</addtitle><date>2006-03</date><risdate>2006</risdate><volume>21</volume><issue>3</issue><spage>388</spage><epage>396</epage><pages>388-396</pages><issn>0884-0431</issn><eissn>1523-4681</eissn><coden>JBMREJ</coden><abstract>Longer survival in cystic fibrosis has led to more bone complications. One hundred thirty‐six young patients were studied for 12‐24 months. Low BMD was found in 66%. Fat mass and lean mass were also reduced. Impaired pulmonary function and total steroid dose had the greatest negative influence on bone.
Introduction: Low BMD is reported as a frequent complication in adult patients affected by cystic fibrosis (CF), but the available data are less consistent for younger patients.
Materials and Methods: This study was designed to evaluate BMD longitudinally over 12‐24 months in a sample of 136 young patients (3‐24 years of age) and to investigate its major determinants. BMC and body composition were also evaluated.
Results: BMD (expressed as Z score) of spine and of total body was reduced in 66% of patients. The prevalence of low BMD was the same in children, adolescents, and young adults. The main determinants of BMD were forced expiratory volume in 1 s (FEV1; as an index of pulmonary function), puberty, platelet count (as an index of portal hypertension), and cumulative steroid dose. Changes of FEV1 over time influenced BMD changes. Bone mass, fat mass (FM) and fat‐free (lean) mass (FFM) were reduced in CF patients at both total body and subregions (trunk, limbs). Lean mass influenced BMD of total body and lower limbs, whereas fat mass (and BMI) influenced spine BMD. FEV1 also influenced FFM.
Conclusions: Low BMD was present in a significant proportion of CF patients, independent of sex and age. BMD depended on pulmonary function, steroid dose, and presence of advanced liver disease. Pulmonary function and puberty were the main stimuli for the increase of BMD over time. CF also altered body composition, and FFM was influenced by pulmonary function.</abstract><cop>Washington, DC</cop><pub>John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR)</pub><pmid>16491286</pmid><doi>10.1359/JBMR.051106</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of bone and mineral research, 2006-03, Vol.21 (3), p.388-396 |
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| source | MEDLINE; Access via Wiley Online Library; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Absorptiometry, Photon Adolescent Biological and medical sciences BMD body composition Body Mass Index Bone Density bone mass Child cystic fibrosis Cystic Fibrosis - metabolism Cystic Fibrosis - pathology Female Fundamental and applied biological sciences. Psychology Humans Longitudinal Studies Lumbar Vertebrae - diagnostic imaging Male pediatrics Skeleton and joints Vertebrates: osteoarticular system, musculoskeletal system |
| title | BMD and Body Composition in Children and Young Patients Affected by Cystic Fibrosis |
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